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Mutagenic and antimutagenic effects of 5-substituted 2'-deoxyuridines depending on the nature of the 5-substituent.

Standard

Mutagenic and antimutagenic effects of 5-substituted 2'-deoxyuridines depending on the nature of the 5-substituent. / Marquardt, H; Westendorf, Johannes; Schaefer, A; Boldt, J; De Clercq, E.

in: ARZNEIMITTEL-FORSCH, Jahrgang 38, Nr. 12, 12, 1988, S. 1820-1824.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Marquardt, H, Westendorf, J, Schaefer, A, Boldt, J & De Clercq, E 1988, 'Mutagenic and antimutagenic effects of 5-substituted 2'-deoxyuridines depending on the nature of the 5-substituent.', ARZNEIMITTEL-FORSCH, Jg. 38, Nr. 12, 12, S. 1820-1824. <http://www.ncbi.nlm.nih.gov/pubmed/3072958?dopt=Citation>

APA

Marquardt, H., Westendorf, J., Schaefer, A., Boldt, J., & De Clercq, E. (1988). Mutagenic and antimutagenic effects of 5-substituted 2'-deoxyuridines depending on the nature of the 5-substituent. ARZNEIMITTEL-FORSCH, 38(12), 1820-1824. [12]. http://www.ncbi.nlm.nih.gov/pubmed/3072958?dopt=Citation

Vancouver

Marquardt H, Westendorf J, Schaefer A, Boldt J, De Clercq E. Mutagenic and antimutagenic effects of 5-substituted 2'-deoxyuridines depending on the nature of the 5-substituent. ARZNEIMITTEL-FORSCH. 1988;38(12):1820-1824. 12.

Bibtex

@article{a823d63aa37f4e50b6c4b238ac9175d6,
title = "Mutagenic and antimutagenic effects of 5-substituted 2'-deoxyuridines depending on the nature of the 5-substituent.",
abstract = "Various 5-substituted pyrimidine 2'-deoxyribosides with anti-herpes activity were investigated for their genotoxic activity. 5-Iodo-2'-deoxycytidine (IDC), 5-(2-chloroethyl)-2'-deoxycytidine (CEDC), 5-(3-chloropropyl)-2'-deoxyuridine (CPDU), (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU), 5-ethyl-2'-deoxyuridine (EDU), 2'-deoxyuridine (DU) and 2'-deoxythymidine (DT) were non-mutagenic in Salmonella typh. as well as in V79 Chinese hamster cells, 5-Iodo-2'-deoxyuridine (IDU) was moderately mutagenic and 5-(2-chloroethyl)-2'deoxyuridine (CEDU) was highly mutagenic in V79 cells; neither IDU nor CEDU were mutagenic in the bacterial assay. None of the compounds induced unscheduled DNA synthesis in primary rat hepatocytes. In addition, antimutagenic effects of 2'-deoxyuridines were discovered: in V79 cells, BVDU, EDU, DU and DT prevented the mutagenicity induced by CEDU; in these cells EDU also inhibited the mutagenicity induced by MNNG. In primary rat hepatocytes, IDU and EDU inhibited the induction of unscheduled DNA synthesis induced by MNNG, DMBA or UV-light. The compounds were inactive at inducing differentiation in hematopoietic cells. The significance of these data, particularly with regard to the use of 5-substituted 2'-deoxyuridines in anti-herpes therapy, is discussed.",
author = "H Marquardt and Johannes Westendorf and A Schaefer and J Boldt and {De Clercq}, E",
year = "1988",
language = "Deutsch",
volume = "38",
pages = "1820--1824",
number = "12",

}

RIS

TY - JOUR

T1 - Mutagenic and antimutagenic effects of 5-substituted 2'-deoxyuridines depending on the nature of the 5-substituent.

AU - Marquardt, H

AU - Westendorf, Johannes

AU - Schaefer, A

AU - Boldt, J

AU - De Clercq, E

PY - 1988

Y1 - 1988

N2 - Various 5-substituted pyrimidine 2'-deoxyribosides with anti-herpes activity were investigated for their genotoxic activity. 5-Iodo-2'-deoxycytidine (IDC), 5-(2-chloroethyl)-2'-deoxycytidine (CEDC), 5-(3-chloropropyl)-2'-deoxyuridine (CPDU), (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU), 5-ethyl-2'-deoxyuridine (EDU), 2'-deoxyuridine (DU) and 2'-deoxythymidine (DT) were non-mutagenic in Salmonella typh. as well as in V79 Chinese hamster cells, 5-Iodo-2'-deoxyuridine (IDU) was moderately mutagenic and 5-(2-chloroethyl)-2'deoxyuridine (CEDU) was highly mutagenic in V79 cells; neither IDU nor CEDU were mutagenic in the bacterial assay. None of the compounds induced unscheduled DNA synthesis in primary rat hepatocytes. In addition, antimutagenic effects of 2'-deoxyuridines were discovered: in V79 cells, BVDU, EDU, DU and DT prevented the mutagenicity induced by CEDU; in these cells EDU also inhibited the mutagenicity induced by MNNG. In primary rat hepatocytes, IDU and EDU inhibited the induction of unscheduled DNA synthesis induced by MNNG, DMBA or UV-light. The compounds were inactive at inducing differentiation in hematopoietic cells. The significance of these data, particularly with regard to the use of 5-substituted 2'-deoxyuridines in anti-herpes therapy, is discussed.

AB - Various 5-substituted pyrimidine 2'-deoxyribosides with anti-herpes activity were investigated for their genotoxic activity. 5-Iodo-2'-deoxycytidine (IDC), 5-(2-chloroethyl)-2'-deoxycytidine (CEDC), 5-(3-chloropropyl)-2'-deoxyuridine (CPDU), (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU), 5-ethyl-2'-deoxyuridine (EDU), 2'-deoxyuridine (DU) and 2'-deoxythymidine (DT) were non-mutagenic in Salmonella typh. as well as in V79 Chinese hamster cells, 5-Iodo-2'-deoxyuridine (IDU) was moderately mutagenic and 5-(2-chloroethyl)-2'deoxyuridine (CEDU) was highly mutagenic in V79 cells; neither IDU nor CEDU were mutagenic in the bacterial assay. None of the compounds induced unscheduled DNA synthesis in primary rat hepatocytes. In addition, antimutagenic effects of 2'-deoxyuridines were discovered: in V79 cells, BVDU, EDU, DU and DT prevented the mutagenicity induced by CEDU; in these cells EDU also inhibited the mutagenicity induced by MNNG. In primary rat hepatocytes, IDU and EDU inhibited the induction of unscheduled DNA synthesis induced by MNNG, DMBA or UV-light. The compounds were inactive at inducing differentiation in hematopoietic cells. The significance of these data, particularly with regard to the use of 5-substituted 2'-deoxyuridines in anti-herpes therapy, is discussed.

M3 - SCORING: Zeitschriftenaufsatz

VL - 38

SP - 1820

EP - 1824

IS - 12

M1 - 12

ER -