Muscle-Bone Crosstalk
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Muscle-Bone Crosstalk : Emerging Opportunities for Novel Therapeutic Approaches to Treat Musculoskeletal Pathologies. / Maurel, Delphine B; Jähn, Katharina; Lara-Castillo, Nuria.
in: BIOMEDICINES, Jahrgang 5, Nr. 4, 24.10.2017, S. E62.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Muscle-Bone Crosstalk
T2 - Emerging Opportunities for Novel Therapeutic Approaches to Treat Musculoskeletal Pathologies
AU - Maurel, Delphine B
AU - Jähn, Katharina
AU - Lara-Castillo, Nuria
PY - 2017/10/24
Y1 - 2017/10/24
N2 - Osteoporosis and sarcopenia are age-related musculoskeletal pathologies that often develop in parallel. Osteoporosis is characterized by a reduced bone mass and an increased fracture risk. Sarcopenia describes muscle wasting with an increasing risk of injuries due to falls. The medical treatment of both diseases costs billions in health care per year. With the impact on public health and economy, and considering the increasing life expectancy of populations, more efficient treatment regimens are sought. The biomechanical interaction between both tissues with muscle acting on bone is well established. Recently, both tissues were also determined as secretory endocrine organs affecting the function of one another. New exciting discoveries on this front are made each year, with novel signaling molecules being discovered and potential controversies being described. While this review does not claim completeness, it will summarize the current knowledge on both the biomechanical and the biochemical link between muscle and bone. The review will highlight the known secreted molecules by both tissues affecting the other and finish with an outlook on novel therapeutics that could emerge from these discoveries.
AB - Osteoporosis and sarcopenia are age-related musculoskeletal pathologies that often develop in parallel. Osteoporosis is characterized by a reduced bone mass and an increased fracture risk. Sarcopenia describes muscle wasting with an increasing risk of injuries due to falls. The medical treatment of both diseases costs billions in health care per year. With the impact on public health and economy, and considering the increasing life expectancy of populations, more efficient treatment regimens are sought. The biomechanical interaction between both tissues with muscle acting on bone is well established. Recently, both tissues were also determined as secretory endocrine organs affecting the function of one another. New exciting discoveries on this front are made each year, with novel signaling molecules being discovered and potential controversies being described. While this review does not claim completeness, it will summarize the current knowledge on both the biomechanical and the biochemical link between muscle and bone. The review will highlight the known secreted molecules by both tissues affecting the other and finish with an outlook on novel therapeutics that could emerge from these discoveries.
KW - Journal Article
KW - Review
U2 - 10.3390/biomedicines5040062
DO - 10.3390/biomedicines5040062
M3 - SCORING: Review article
C2 - 29064421
VL - 5
SP - E62
JO - BIOMEDICINES
JF - BIOMEDICINES
SN - 2227-9059
IS - 4
ER -