Multivariate analysis of urinary RNA catabolites in malignancies: cross-sectional and longitudinal studies.

TY - JOUR

T1 - Multivariate analysis of urinary RNA catabolites in malignancies: cross-sectional and longitudinal studies.

AU - Müller, J

AU - Erb, Norbert

AU - Heller-Schöch, G

AU - Lorenz, H

AU - Winkler, K

AU - Schöch, G

PY - 1983

Y1 - 1983

N2 - Urinary RNA catabolites, especially modified nucleosides and nucleobases, have turned out to represent valuable new criteria for diagnosis and follow-up of malignancies. Here we show for the first time that multivariate analysis of urinary RNA catabolites can distinguish between tumor carriers and controls who, if examined by univariate procedures, would remain undifferentiated. Two such models have been demonstrated. We hope that a continuation of this work will support primary clinical diagnostic procedures, the control of therapy effects, and the long-term follow-up of patients, which should be regarded as special medical applications of the general principles of molecular biology.

AB - Urinary RNA catabolites, especially modified nucleosides and nucleobases, have turned out to represent valuable new criteria for diagnosis and follow-up of malignancies. Here we show for the first time that multivariate analysis of urinary RNA catabolites can distinguish between tumor carriers and controls who, if examined by univariate procedures, would remain undifferentiated. Two such models have been demonstrated. We hope that a continuation of this work will support primary clinical diagnostic procedures, the control of therapy effects, and the long-term follow-up of patients, which should be regarded as special medical applications of the general principles of molecular biology.

M3 - SCORING: Zeitschriftenaufsatz

VL - 84

SP - 317

EP - 330

JO - Recent Results Cancer Res

JF - Recent Results Cancer Res

SN - 0080-0015

ER -