Multisensory processing and oscillatory activity: analyzing non-linear electrophysiological measures in humans and simians.
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Multisensory processing and oscillatory activity: analyzing non-linear electrophysiological measures in humans and simians. / Senkowski, Daniel; Gomez-Ramirez, Manuel; Lakatos, Peter; Wylie, Glenn R; Molholm, Sophie; Schroeder, Charles E; Foxe, John J.
in: EXP BRAIN RES, Jahrgang 177, Nr. 2, 2, 2007, S. 184-195.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Multisensory processing and oscillatory activity: analyzing non-linear electrophysiological measures in humans and simians.
AU - Senkowski, Daniel
AU - Gomez-Ramirez, Manuel
AU - Lakatos, Peter
AU - Wylie, Glenn R
AU - Molholm, Sophie
AU - Schroeder, Charles E
AU - Foxe, John J
PY - 2007
Y1 - 2007
N2 - Stimulus-related oscillations are known to be closely linked to integrative processing in the brain. One research domain within which there has been tremendous interest in oscillatory mechanisms is in the integration of inputs across the widely separated sensory systems. Under the standard approach of assessing multisensory interactions in electrophysiological datasets, the event-related response to a multisensory stimulus is directly compared with the sum of the responses to its unisensory constituents when presented alone. When using methods like wavelet transformation or fast Fourier transformation to derive induced oscillatory signals, however, such linear operations are not appropriate. Here we introduce a simple bootstrapping procedure wherein the linear summation of single unisensory trials forms a distribution against which multisensory trials may be statistically compared, an approach that circumvents the issue of non-linearity when combining unisensory oscillatory responses. To test this approach we applied it to datasets from intracranial recordings in non-human primates and human scalp-recorded EEG, both derived from a simple audio-visual integration paradigm. Significant multisensory interactions were revealed in oscillatory activity centered at 15 and 20 Hz (the so-called beta band). Simulations of different levels of background noise further validated the results obtained by this method. By demonstrating super- and sub-additive effects, our analyses showed that this approach is a valuable metric for studying multisensory interactions reflected in induced oscillatory responses.
AB - Stimulus-related oscillations are known to be closely linked to integrative processing in the brain. One research domain within which there has been tremendous interest in oscillatory mechanisms is in the integration of inputs across the widely separated sensory systems. Under the standard approach of assessing multisensory interactions in electrophysiological datasets, the event-related response to a multisensory stimulus is directly compared with the sum of the responses to its unisensory constituents when presented alone. When using methods like wavelet transformation or fast Fourier transformation to derive induced oscillatory signals, however, such linear operations are not appropriate. Here we introduce a simple bootstrapping procedure wherein the linear summation of single unisensory trials forms a distribution against which multisensory trials may be statistically compared, an approach that circumvents the issue of non-linearity when combining unisensory oscillatory responses. To test this approach we applied it to datasets from intracranial recordings in non-human primates and human scalp-recorded EEG, both derived from a simple audio-visual integration paradigm. Significant multisensory interactions were revealed in oscillatory activity centered at 15 and 20 Hz (the so-called beta band). Simulations of different levels of background noise further validated the results obtained by this method. By demonstrating super- and sub-additive effects, our analyses showed that this approach is a valuable metric for studying multisensory interactions reflected in induced oscillatory responses.
M3 - SCORING: Zeitschriftenaufsatz
VL - 177
SP - 184
EP - 195
JO - EXP BRAIN RES
JF - EXP BRAIN RES
SN - 0014-4819
IS - 2
M1 - 2
ER -