Multisensory integration in rodent tactile but not visual thalamus
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Multisensory integration in rodent tactile but not visual thalamus. / Bieler, Malte; Xu, Xiaxia; Marquardt, Annette; Hanganu-Opatz, Ileana L.
in: SCI REP-UK, Jahrgang 8, Nr. 1, 24.10.2018, S. 15684.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Multisensory integration in rodent tactile but not visual thalamus
AU - Bieler, Malte
AU - Xu, Xiaxia
AU - Marquardt, Annette
AU - Hanganu-Opatz, Ileana L
PY - 2018/10/24
Y1 - 2018/10/24
N2 - Behavioural performance requires a coherent perception of environmental features that address multiple senses. These diverse sensory inputs are integrated in primary sensory cortices, yet it is still largely unknown whether their convergence occurs even earlier along the sensory tract. Here we investigate the role of putatively modality-specific first-order (FO) thalamic nuclei (ventral posteromedial nucleus (VPM), dorsal lateral geniculate nucleus (dLGN)) and their interactions with primary sensory cortices (S1, V1) for multisensory integration in pigmented rats in vivo. We show that bimodal stimulation (i.e. simultaneous light flash and whisker deflection) enhances sensory evoked activity in VPM, but not dLGN. Moreover, cross-modal stimuli reset the phase of thalamic network oscillations and strengthen the coupling efficiency between VPM and S1, but not between dLGN and V1. Finally, the information flow from VPM to S1 is enhanced. Thus, FO tactile, but not visual, thalamus processes and relays sensory inputs from multiple senses, revealing a functional difference between sensory thalamic nuclei during multisensory integration.
AB - Behavioural performance requires a coherent perception of environmental features that address multiple senses. These diverse sensory inputs are integrated in primary sensory cortices, yet it is still largely unknown whether their convergence occurs even earlier along the sensory tract. Here we investigate the role of putatively modality-specific first-order (FO) thalamic nuclei (ventral posteromedial nucleus (VPM), dorsal lateral geniculate nucleus (dLGN)) and their interactions with primary sensory cortices (S1, V1) for multisensory integration in pigmented rats in vivo. We show that bimodal stimulation (i.e. simultaneous light flash and whisker deflection) enhances sensory evoked activity in VPM, but not dLGN. Moreover, cross-modal stimuli reset the phase of thalamic network oscillations and strengthen the coupling efficiency between VPM and S1, but not between dLGN and V1. Finally, the information flow from VPM to S1 is enhanced. Thus, FO tactile, but not visual, thalamus processes and relays sensory inputs from multiple senses, revealing a functional difference between sensory thalamic nuclei during multisensory integration.
KW - Journal Article
U2 - 10.1038/s41598-018-33815-y
DO - 10.1038/s41598-018-33815-y
M3 - SCORING: Journal article
C2 - 30356135
VL - 8
SP - 15684
JO - SCI REP-UK
JF - SCI REP-UK
SN - 2045-2322
IS - 1
ER -