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Multiply myelinated axons in the optic nerve of mice deficient for the myelin-associated glycoprotein

Standard

Multiply myelinated axons in the optic nerve of mice deficient for the myelin-associated glycoprotein. / Bartsch, U; Montag, D; Bartsch, S; Schachner, M.

in: GLIA, Jahrgang 14, Nr. 2, 06.1995, S. 115-22.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Bartsch, U, Montag, D, Bartsch, S & Schachner, M 1995, 'Multiply myelinated axons in the optic nerve of mice deficient for the myelin-associated glycoprotein', GLIA, Jg. 14, Nr. 2, S. 115-22. https://doi.org/10.1002/glia.440140206

APA

Bartsch, U., Montag, D., Bartsch, S., & Schachner, M. (1995). Multiply myelinated axons in the optic nerve of mice deficient for the myelin-associated glycoprotein. GLIA, 14(2), 115-22. https://doi.org/10.1002/glia.440140206

Vancouver

Bartsch U, Montag D, Bartsch S, Schachner M. Multiply myelinated axons in the optic nerve of mice deficient for the myelin-associated glycoprotein. GLIA. 1995 Jun;14(2):115-22. https://doi.org/10.1002/glia.440140206

Bibtex

@article{5eaccf4c1413420492fc56257537a09c,
title = "Multiply myelinated axons in the optic nerve of mice deficient for the myelin-associated glycoprotein",
abstract = "We recently reported that some retinal ganglion cell axons in mice deficient for the myelin-associated glycoprotein are concentrically surrounded by more than one myelin sheath. In the present study, we demonstrate that myelin sheaths displaced from the axon reveal a normal ultrastructure of compact myelin, with the only exception that multiple myelination of axons frequently correlates with the presence of unfused regions of major dense lines. Supernumerary sheaths terminated on other sheaths or on astrocyte cell surfaces in a pattern closely resembling the morphology of a true paranode. The thickness of compact myelin of multiply myelinated axons was significantly increased when compared with axons of similar caliber surrounded by a single myelin sheath. Our observations demonstrate that maintenance of compact myelin and paranodal regions is not dependent on direct axonal contact and that the presence of more than one concentric myelin sheath around an axon results in dysregulation of the axon-to-fiber ratio.",
keywords = "Animals, Axons, Mice, Mice, Inbred Strains, Microscopy, Electron, Myelin Sheath, Myelin-Associated Glycoprotein, Nerve Fibers, Myelinated, Optic Nerve, Journal Article",
author = "U Bartsch and D Montag and S Bartsch and M Schachner",
year = "1995",
month = jun,
doi = "10.1002/glia.440140206",
language = "English",
volume = "14",
pages = "115--22",
journal = "GLIA",
issn = "0894-1491",
publisher = "John Wiley and Sons Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - Multiply myelinated axons in the optic nerve of mice deficient for the myelin-associated glycoprotein

AU - Bartsch, U

AU - Montag, D

AU - Bartsch, S

AU - Schachner, M

PY - 1995/6

Y1 - 1995/6

N2 - We recently reported that some retinal ganglion cell axons in mice deficient for the myelin-associated glycoprotein are concentrically surrounded by more than one myelin sheath. In the present study, we demonstrate that myelin sheaths displaced from the axon reveal a normal ultrastructure of compact myelin, with the only exception that multiple myelination of axons frequently correlates with the presence of unfused regions of major dense lines. Supernumerary sheaths terminated on other sheaths or on astrocyte cell surfaces in a pattern closely resembling the morphology of a true paranode. The thickness of compact myelin of multiply myelinated axons was significantly increased when compared with axons of similar caliber surrounded by a single myelin sheath. Our observations demonstrate that maintenance of compact myelin and paranodal regions is not dependent on direct axonal contact and that the presence of more than one concentric myelin sheath around an axon results in dysregulation of the axon-to-fiber ratio.

AB - We recently reported that some retinal ganglion cell axons in mice deficient for the myelin-associated glycoprotein are concentrically surrounded by more than one myelin sheath. In the present study, we demonstrate that myelin sheaths displaced from the axon reveal a normal ultrastructure of compact myelin, with the only exception that multiple myelination of axons frequently correlates with the presence of unfused regions of major dense lines. Supernumerary sheaths terminated on other sheaths or on astrocyte cell surfaces in a pattern closely resembling the morphology of a true paranode. The thickness of compact myelin of multiply myelinated axons was significantly increased when compared with axons of similar caliber surrounded by a single myelin sheath. Our observations demonstrate that maintenance of compact myelin and paranodal regions is not dependent on direct axonal contact and that the presence of more than one concentric myelin sheath around an axon results in dysregulation of the axon-to-fiber ratio.

KW - Animals

KW - Axons

KW - Mice

KW - Mice, Inbred Strains

KW - Microscopy, Electron

KW - Myelin Sheath

KW - Myelin-Associated Glycoprotein

KW - Nerve Fibers, Myelinated

KW - Optic Nerve

KW - Journal Article

U2 - 10.1002/glia.440140206

DO - 10.1002/glia.440140206

M3 - SCORING: Journal article

C2 - 7558238

VL - 14

SP - 115

EP - 122

JO - GLIA

JF - GLIA

SN - 0894-1491

IS - 2

ER -