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Multiple-pinhole collimators improve intra- and between-rater agreement and the certainty of the visual interpretation in dopamine transporter SPECT

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Multiple-pinhole collimators improve intra- and between-rater agreement and the certainty of the visual interpretation in dopamine transporter SPECT. / Mathies, Franziska; Apostolova, Ivayla; Dierck, Lena; Jacobi, Janin; Kuen, Katja; Sauer, Markus; Schenk, Michael; Klutmann, Susanne; Forgács, Attila; Buchert, Ralph.

in: EJNMMI RES, Jahrgang 12, Nr. 1, 51, 17.08.2022, S. 51.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Mathies, F, Apostolova, I, Dierck, L, Jacobi, J, Kuen, K, Sauer, M, Schenk, M, Klutmann, S, Forgács, A & Buchert, R 2022, 'Multiple-pinhole collimators improve intra- and between-rater agreement and the certainty of the visual interpretation in dopamine transporter SPECT', EJNMMI RES, Jg. 12, Nr. 1, 51, S. 51. https://doi.org/10.1186/s13550-022-00923-w

APA

Mathies, F., Apostolova, I., Dierck, L., Jacobi, J., Kuen, K., Sauer, M., Schenk, M., Klutmann, S., Forgács, A., & Buchert, R. (2022). Multiple-pinhole collimators improve intra- and between-rater agreement and the certainty of the visual interpretation in dopamine transporter SPECT. EJNMMI RES, 12(1), 51. [51]. https://doi.org/10.1186/s13550-022-00923-w

Vancouver

Mathies F, Apostolova I, Dierck L, Jacobi J, Kuen K, Sauer M et al. Multiple-pinhole collimators improve intra- and between-rater agreement and the certainty of the visual interpretation in dopamine transporter SPECT. EJNMMI RES. 2022 Aug 17;12(1):51. 51. https://doi.org/10.1186/s13550-022-00923-w

Bibtex

@article{26803fa4503845da84fc95be7f835a49,
title = "Multiple-pinhole collimators improve intra- and between-rater agreement and the certainty of the visual interpretation in dopamine transporter SPECT",
abstract = "BackgroundMultiple-pinhole (MPH) collimators improve the resolution–sensitivity trade-off compared to parallel-hole collimators. This study evaluated the impact of MPH collimators on intra- and between-rater agreement, and on the certainty of visual interpretation in dopamine transporter (DAT)-SPECT.MethodsThe study included 71 patients (62.1 ± 12.7 y). Two SPECT acquisitions were performed in randomized order after a single injection of 182 ± 9 MBq 123I-FP-CIT, one with MPH and one with low-energy–high-resolution–high-sensitivity (LEHRHS) collimators. MPH projections were reconstructed with an iterative 3d Monte Carlo algorithm. LEHRHS projections were reconstructed with filtered backprojection (FBP) or with ordered-subsets expectation–maximization and resolution recovery (OSEM). Images were visually evaluated twice by three independent raters with respect to presence/absence of Parkinson-typical reduction of striatal 123I-FP-CIT uptake using a Likert 6-score (− 3 = clearly normal, …, 3 = clearly reduced). In case of intra-rater discrepancy, an intra-rater consensus was obtained. Intra- and between-rater agreement with respect to the Likert score (6-score and dichotomized score) was characterized by Cohen{\textquoteright}s kappa.ResultsIntra-rater kappa of visual scoring of MPH/LEHRHS-OSEM/LEHRHS-FBP images was 0.84 ± 0.12/0.73 ± 0.06/0.73 ± 0.08 (6-score, mean of three raters) and 1.00 ± 0.00/0.96 ± 0.04/0.97 ± 0.03 (dichotomized score). Between-rater kappa of visual scoring (intra-rater consensus) of MPH/LEHRHS-OSEM/LEHRHS-FBP images was 0.70 ± 0.06/0.63 ± 0.08/0.48 ± 0.05 (6-score, mean of three pairs of raters) and 1.00 ± 0.00/0.92 ± 0.04/0.90 ± 0.06 (dichotomized score). There was a decrease of (negative) Likert scores in normal DAT-SPECT by 0.87 ± 0.18 points from the LEHRHS-OSEM to the MPH setting. The (positive) Likert scores of reduced DAT-SPECT did not change on average.ConclusionsMPH collimators improve intra- and between-rater agreement as well as the certainty of the visual interpretation of DAT-SPECT.",
author = "Franziska Mathies and Ivayla Apostolova and Lena Dierck and Janin Jacobi and Katja Kuen and Markus Sauer and Michael Schenk and Susanne Klutmann and Attila Forg{\'a}cs and Ralph Buchert",
year = "2022",
month = aug,
day = "17",
doi = "10.1186/s13550-022-00923-w",
language = "English",
volume = "12",
pages = "51",
journal = "EJNMMI RES",
issn = "2191-219X",
publisher = "Springer",
number = "1",

}

RIS

TY - JOUR

T1 - Multiple-pinhole collimators improve intra- and between-rater agreement and the certainty of the visual interpretation in dopamine transporter SPECT

AU - Mathies, Franziska

AU - Apostolova, Ivayla

AU - Dierck, Lena

AU - Jacobi, Janin

AU - Kuen, Katja

AU - Sauer, Markus

AU - Schenk, Michael

AU - Klutmann, Susanne

AU - Forgács, Attila

AU - Buchert, Ralph

PY - 2022/8/17

Y1 - 2022/8/17

N2 - BackgroundMultiple-pinhole (MPH) collimators improve the resolution–sensitivity trade-off compared to parallel-hole collimators. This study evaluated the impact of MPH collimators on intra- and between-rater agreement, and on the certainty of visual interpretation in dopamine transporter (DAT)-SPECT.MethodsThe study included 71 patients (62.1 ± 12.7 y). Two SPECT acquisitions were performed in randomized order after a single injection of 182 ± 9 MBq 123I-FP-CIT, one with MPH and one with low-energy–high-resolution–high-sensitivity (LEHRHS) collimators. MPH projections were reconstructed with an iterative 3d Monte Carlo algorithm. LEHRHS projections were reconstructed with filtered backprojection (FBP) or with ordered-subsets expectation–maximization and resolution recovery (OSEM). Images were visually evaluated twice by three independent raters with respect to presence/absence of Parkinson-typical reduction of striatal 123I-FP-CIT uptake using a Likert 6-score (− 3 = clearly normal, …, 3 = clearly reduced). In case of intra-rater discrepancy, an intra-rater consensus was obtained. Intra- and between-rater agreement with respect to the Likert score (6-score and dichotomized score) was characterized by Cohen’s kappa.ResultsIntra-rater kappa of visual scoring of MPH/LEHRHS-OSEM/LEHRHS-FBP images was 0.84 ± 0.12/0.73 ± 0.06/0.73 ± 0.08 (6-score, mean of three raters) and 1.00 ± 0.00/0.96 ± 0.04/0.97 ± 0.03 (dichotomized score). Between-rater kappa of visual scoring (intra-rater consensus) of MPH/LEHRHS-OSEM/LEHRHS-FBP images was 0.70 ± 0.06/0.63 ± 0.08/0.48 ± 0.05 (6-score, mean of three pairs of raters) and 1.00 ± 0.00/0.92 ± 0.04/0.90 ± 0.06 (dichotomized score). There was a decrease of (negative) Likert scores in normal DAT-SPECT by 0.87 ± 0.18 points from the LEHRHS-OSEM to the MPH setting. The (positive) Likert scores of reduced DAT-SPECT did not change on average.ConclusionsMPH collimators improve intra- and between-rater agreement as well as the certainty of the visual interpretation of DAT-SPECT.

AB - BackgroundMultiple-pinhole (MPH) collimators improve the resolution–sensitivity trade-off compared to parallel-hole collimators. This study evaluated the impact of MPH collimators on intra- and between-rater agreement, and on the certainty of visual interpretation in dopamine transporter (DAT)-SPECT.MethodsThe study included 71 patients (62.1 ± 12.7 y). Two SPECT acquisitions were performed in randomized order after a single injection of 182 ± 9 MBq 123I-FP-CIT, one with MPH and one with low-energy–high-resolution–high-sensitivity (LEHRHS) collimators. MPH projections were reconstructed with an iterative 3d Monte Carlo algorithm. LEHRHS projections were reconstructed with filtered backprojection (FBP) or with ordered-subsets expectation–maximization and resolution recovery (OSEM). Images were visually evaluated twice by three independent raters with respect to presence/absence of Parkinson-typical reduction of striatal 123I-FP-CIT uptake using a Likert 6-score (− 3 = clearly normal, …, 3 = clearly reduced). In case of intra-rater discrepancy, an intra-rater consensus was obtained. Intra- and between-rater agreement with respect to the Likert score (6-score and dichotomized score) was characterized by Cohen’s kappa.ResultsIntra-rater kappa of visual scoring of MPH/LEHRHS-OSEM/LEHRHS-FBP images was 0.84 ± 0.12/0.73 ± 0.06/0.73 ± 0.08 (6-score, mean of three raters) and 1.00 ± 0.00/0.96 ± 0.04/0.97 ± 0.03 (dichotomized score). Between-rater kappa of visual scoring (intra-rater consensus) of MPH/LEHRHS-OSEM/LEHRHS-FBP images was 0.70 ± 0.06/0.63 ± 0.08/0.48 ± 0.05 (6-score, mean of three pairs of raters) and 1.00 ± 0.00/0.92 ± 0.04/0.90 ± 0.06 (dichotomized score). There was a decrease of (negative) Likert scores in normal DAT-SPECT by 0.87 ± 0.18 points from the LEHRHS-OSEM to the MPH setting. The (positive) Likert scores of reduced DAT-SPECT did not change on average.ConclusionsMPH collimators improve intra- and between-rater agreement as well as the certainty of the visual interpretation of DAT-SPECT.

U2 - 10.1186/s13550-022-00923-w

DO - 10.1186/s13550-022-00923-w

M3 - SCORING: Journal article

C2 - 35976493

VL - 12

SP - 51

JO - EJNMMI RES

JF - EJNMMI RES

SN - 2191-219X

IS - 1

M1 - 51

ER -