Multiple inflammatory biomarkers in relation to cardiovascular events and mortality in the community
Standard
Multiple inflammatory biomarkers in relation to cardiovascular events and mortality in the community. / Schnabel, Renate B; Yin, Xiaoyan; Larson, Martin G; Yamamoto, Jennifer F; Fontes, João D; Kathiresan, Sekar; Rong, Jian; Levy, Daniel; Keaney, John F; Wang, Thomas J; Murabito, Joanne M; Vasan, Ramachandran S; Benjamin, Emelia J.
in: ARTERIOSCL THROM VAS, Jahrgang 33, Nr. 7, 07.2013, S. 1728-1733.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Multiple inflammatory biomarkers in relation to cardiovascular events and mortality in the community
AU - Schnabel, Renate B
AU - Yin, Xiaoyan
AU - Larson, Martin G
AU - Yamamoto, Jennifer F
AU - Fontes, João D
AU - Kathiresan, Sekar
AU - Rong, Jian
AU - Levy, Daniel
AU - Keaney, John F
AU - Wang, Thomas J
AU - Murabito, Joanne M
AU - Vasan, Ramachandran S
AU - Benjamin, Emelia J
PY - 2013/7
Y1 - 2013/7
N2 - OBJECTIVE: Evidence suggests that chronic low-grade inflammation and oxidative stress are related to cardiovascular disease (CVD) and mortality.APPROACH AND RESULTS: We examined 11 established and novel biomarkers representing inflammation and oxidative stress (C-reactive protein, fibrinogen, interleukin-6, intercellular adhesion molecule-1, lipoprotein-associated phospholipase-A2 [mass and activity], monocyte chemoattractant protein-1, myeloperoxidase, CD40 ligand, P-selectin, and tumor necrosis factor receptor II [TNFRII]) in relation to incident major CVD and mortality in the community. We studied 3035 participants (mean age, 61 ± 9 years; 53% women). During follow-up (median, 8.9 years), 253 participants experienced a CVD event and 343 died. C-reactive protein (hazard ratio [HR] reported per SD ln-transformed biomarker, 1.18; 95% confidence interval [CI], 1.02-1.35; nominal P=0.02) and TNFRII (HR, 1.15; 95% CI, 1.01-1.32; nominal P=0.04) were retained in multivariable-adjusted models for major CVD, but were not significant after adjustment for multiple testing. The biomarkers related to mortality were TNFRII (HR, 1.33; 95% CI, 1.19-1.49; P<0.0001), ICAM-1 (HR, 1.24; 95% CI, 1.12-1.37; P<0.0001), and interleukin-6 (HR, 1.25; 95% CI, 1.12-1.39; P<0.0001). The addition of these markers to the model, including traditional risk factors, increased discrimination and reclassification for risk of death (P<0.0001), but not for CVD.CONCLUSIONS: Of 11 inflammatory biomarkers tumor necrosis factor receptor II was related to cardiovascular disease and mortality in the Framingham Heart Study. The combination of TNFRII with C-reactive protein in relation to CVD and with interleukin-6 to mortality increased the predictive ability in addition to CVD risk factors for total mortality but not for incident CVD.
AB - OBJECTIVE: Evidence suggests that chronic low-grade inflammation and oxidative stress are related to cardiovascular disease (CVD) and mortality.APPROACH AND RESULTS: We examined 11 established and novel biomarkers representing inflammation and oxidative stress (C-reactive protein, fibrinogen, interleukin-6, intercellular adhesion molecule-1, lipoprotein-associated phospholipase-A2 [mass and activity], monocyte chemoattractant protein-1, myeloperoxidase, CD40 ligand, P-selectin, and tumor necrosis factor receptor II [TNFRII]) in relation to incident major CVD and mortality in the community. We studied 3035 participants (mean age, 61 ± 9 years; 53% women). During follow-up (median, 8.9 years), 253 participants experienced a CVD event and 343 died. C-reactive protein (hazard ratio [HR] reported per SD ln-transformed biomarker, 1.18; 95% confidence interval [CI], 1.02-1.35; nominal P=0.02) and TNFRII (HR, 1.15; 95% CI, 1.01-1.32; nominal P=0.04) were retained in multivariable-adjusted models for major CVD, but were not significant after adjustment for multiple testing. The biomarkers related to mortality were TNFRII (HR, 1.33; 95% CI, 1.19-1.49; P<0.0001), ICAM-1 (HR, 1.24; 95% CI, 1.12-1.37; P<0.0001), and interleukin-6 (HR, 1.25; 95% CI, 1.12-1.39; P<0.0001). The addition of these markers to the model, including traditional risk factors, increased discrimination and reclassification for risk of death (P<0.0001), but not for CVD.CONCLUSIONS: Of 11 inflammatory biomarkers tumor necrosis factor receptor II was related to cardiovascular disease and mortality in the Framingham Heart Study. The combination of TNFRII with C-reactive protein in relation to CVD and with interleukin-6 to mortality increased the predictive ability in addition to CVD risk factors for total mortality but not for incident CVD.
KW - Aged
KW - Biomarkers/blood
KW - C-Reactive Protein/metabolism
KW - Cardiovascular Diseases/blood
KW - Disease-Free Survival
KW - Female
KW - Health Surveys
KW - Humans
KW - Incidence
KW - Inflammation/blood
KW - Inflammation Mediators/blood
KW - Intercellular Adhesion Molecule-1/blood
KW - Interleukin-6/blood
KW - Male
KW - Massachusetts/epidemiology
KW - Middle Aged
KW - Multivariate Analysis
KW - Principal Component Analysis
KW - Prognosis
KW - Proportional Hazards Models
KW - Receptors, Tumor Necrosis Factor, Type II/blood
KW - Risk Assessment
KW - Risk Factors
KW - Time Factors
U2 - 10.1161/ATVBAHA.112.301174
DO - 10.1161/ATVBAHA.112.301174
M3 - SCORING: Journal article
C2 - 23640499
VL - 33
SP - 1728
EP - 1733
JO - ARTERIOSCL THROM VAS
JF - ARTERIOSCL THROM VAS
SN - 1079-5642
IS - 7
ER -
