Multiple endothelial biomarkers and noninvasive vascular function in the general population: the Gutenberg Health Study
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Multiple endothelial biomarkers and noninvasive vascular function in the general population: the Gutenberg Health Study. / Schnabel, Renate B; Wild, Philipp S; Schulz, Andreas; Zeller, Tanja; Sinning, Christoph R; Wilde, Sandra; Kunde, Jan; Lubos, Edith; Lackner, Karl J; Warnholtz, Ascan; Gori, Tommaso; Blankenberg, Stefan; Munzel, Thomas; Gutenberg Health Study investigators.
in: HYPERTENSION, Jahrgang 60, Nr. 2, 08.2012, S. 288-295.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Multiple endothelial biomarkers and noninvasive vascular function in the general population: the Gutenberg Health Study
AU - Schnabel, Renate B
AU - Wild, Philipp S
AU - Schulz, Andreas
AU - Zeller, Tanja
AU - Sinning, Christoph R
AU - Wilde, Sandra
AU - Kunde, Jan
AU - Lubos, Edith
AU - Lackner, Karl J
AU - Warnholtz, Ascan
AU - Gori, Tommaso
AU - Blankenberg, Stefan
AU - Munzel, Thomas
AU - Gutenberg Health Study investigators
PY - 2012/8
Y1 - 2012/8
N2 - Vascular reactivity is reflected by blood biomarkers and noninvasive vascular function measurement. The relation of biomarkers to flow-mediated dilation and peripheral arterial tonometry in the general population is little understood. In 5000 individuals (mean age, 56±11 years; age range, 35-74 years; 49% women) of the population-based Gutenberg Health Study we simultaneously assessed 6 biomarkers of cardiovascular function (midregional proadrenomedullin [MR-proADM], midregional pro atrial natriuretic peptide [MR-proANP], N-terminal pro B-type natriuretic peptide, copeptin, C-terminal proendothelin 1, and neopterin) in relation to flow-mediated dilation and peripheral arterial tonometry. Strongest partial correlations (adjusted for age and sex) were observed for baseline pulse amplitude with MR-proADM (r=0.13) and MR-proANP (r=-0.13); hyperemic response variables showed the highest correlation for MR-proADM and peripheral arterial tonometry ratio (r=-0.14). In multivariable linear regression models, strongest associations with baseline vascular function were observed for MR-proANP with baseline pulse amplitude (β per SD increase [99.17%], -0.080 [-0.115 to -0.044]; P<0.0001 after Bonferroni correction for multiple testing) and MR-proADM (-0.044 [-0.070 to -0.017]; P<0.0001), as well as MR-proANP (-0.033 [-0.057 to -0.009]; P=0.0017) and N-terminal pro B-type natriuretic peptide (-0.027 [-0.051 to -0.003]; P=0.015) with brachial artery diameter. For hyperemic response variables, highest associations were seen for peripheral arterial tonometry ratio with MR-proADM (-0.022 [-0.043 to -0.004]; P=0.043), MR-proANP (0.016 [-0.0034 to 0.035]; P=0.18), and C-terminal proendothelin 1 (-0.025 [-0.043 to -0.008]; P=0.00094]. In our large, population-based study, we identified MR-proADM and MR-proANP as circulating biomarkers of vascular function most strongly related to noninvasive measures of conduit artery and peripheral arterial performance. Whether determination of blood biomarkers helps to better understand vascular pathology and may provide prognostic information needs to be investigated in future studies.
AB - Vascular reactivity is reflected by blood biomarkers and noninvasive vascular function measurement. The relation of biomarkers to flow-mediated dilation and peripheral arterial tonometry in the general population is little understood. In 5000 individuals (mean age, 56±11 years; age range, 35-74 years; 49% women) of the population-based Gutenberg Health Study we simultaneously assessed 6 biomarkers of cardiovascular function (midregional proadrenomedullin [MR-proADM], midregional pro atrial natriuretic peptide [MR-proANP], N-terminal pro B-type natriuretic peptide, copeptin, C-terminal proendothelin 1, and neopterin) in relation to flow-mediated dilation and peripheral arterial tonometry. Strongest partial correlations (adjusted for age and sex) were observed for baseline pulse amplitude with MR-proADM (r=0.13) and MR-proANP (r=-0.13); hyperemic response variables showed the highest correlation for MR-proADM and peripheral arterial tonometry ratio (r=-0.14). In multivariable linear regression models, strongest associations with baseline vascular function were observed for MR-proANP with baseline pulse amplitude (β per SD increase [99.17%], -0.080 [-0.115 to -0.044]; P<0.0001 after Bonferroni correction for multiple testing) and MR-proADM (-0.044 [-0.070 to -0.017]; P<0.0001), as well as MR-proANP (-0.033 [-0.057 to -0.009]; P=0.0017) and N-terminal pro B-type natriuretic peptide (-0.027 [-0.051 to -0.003]; P=0.015) with brachial artery diameter. For hyperemic response variables, highest associations were seen for peripheral arterial tonometry ratio with MR-proADM (-0.022 [-0.043 to -0.004]; P=0.043), MR-proANP (0.016 [-0.0034 to 0.035]; P=0.18), and C-terminal proendothelin 1 (-0.025 [-0.043 to -0.008]; P=0.00094]. In our large, population-based study, we identified MR-proADM and MR-proANP as circulating biomarkers of vascular function most strongly related to noninvasive measures of conduit artery and peripheral arterial performance. Whether determination of blood biomarkers helps to better understand vascular pathology and may provide prognostic information needs to be investigated in future studies.
KW - Adrenomedullin/blood
KW - Adult
KW - Aged
KW - Atrial Natriuretic Factor/blood
KW - Biomarkers/blood
KW - Brachial Artery/physiology
KW - Cohort Studies
KW - Cross-Sectional Studies
KW - Endothelin-1/blood
KW - Endothelium, Vascular/physiology
KW - Female
KW - Germany
KW - Glycopeptides/blood
KW - Humans
KW - Male
KW - Manometry
KW - Middle Aged
KW - Natriuretic Peptide, Brain/blood
KW - Neopterin/blood
KW - Peptide Fragments/blood
KW - Protein Precursors/blood
KW - Regional Blood Flow/physiology
U2 - 10.1161/HYPERTENSIONAHA.112.191874
DO - 10.1161/HYPERTENSIONAHA.112.191874
M3 - SCORING: Journal article
C2 - 22689741
VL - 60
SP - 288
EP - 295
JO - HYPERTENSION
JF - HYPERTENSION
SN - 0194-911X
IS - 2
ER -