Multiple dynamic representations in the motor cortex during sensorimotor learning.
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Multiple dynamic representations in the motor cortex during sensorimotor learning. / Huber, D; Gutnisky, D A; Peron, S; O'Connor, D H; Wiegert, J. Simon; Tian, L; Oertner, Thomas G.; Looger, L L; Svoboda, K.
in: NATURE, Jahrgang 484, Nr. 7395, 7395, 2012, S. 473-478.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Multiple dynamic representations in the motor cortex during sensorimotor learning.
AU - Huber, D
AU - Gutnisky, D A
AU - Peron, S
AU - O'Connor, D H
AU - Wiegert, J. Simon
AU - Tian, L
AU - Oertner, Thomas G.
AU - Looger, L L
AU - Svoboda, K
PY - 2012
Y1 - 2012
N2 - The mechanisms linking sensation and action during learning are poorly understood. Layer 2/3 neurons in the motor cortex might participate in sensorimotor integration and learning; they receive input from sensory cortex and excite deep layer neurons, which control movement. Here we imaged activity in the same set of layer 2/3 neurons in the motor cortex over weeks, while mice learned to detect objects with their whiskers and report detection with licking. Spatially intermingled neurons represented sensory (touch) and motor behaviours (whisker movements and licking). With learning, the population-level representation of task-related licking strengthened. In trained mice, population-level representations were redundant and stable, despite dynamism of single-neuron representations. The activity of a subpopulation of neurons was consistent with touch driving licking behaviour. Our results suggest that ensembles of motor cortex neurons couple sensory input to multiple, related motor programs during learning.
AB - The mechanisms linking sensation and action during learning are poorly understood. Layer 2/3 neurons in the motor cortex might participate in sensorimotor integration and learning; they receive input from sensory cortex and excite deep layer neurons, which control movement. Here we imaged activity in the same set of layer 2/3 neurons in the motor cortex over weeks, while mice learned to detect objects with their whiskers and report detection with licking. Spatially intermingled neurons represented sensory (touch) and motor behaviours (whisker movements and licking). With learning, the population-level representation of task-related licking strengthened. In trained mice, population-level representations were redundant and stable, despite dynamism of single-neuron representations. The activity of a subpopulation of neurons was consistent with touch driving licking behaviour. Our results suggest that ensembles of motor cortex neurons couple sensory input to multiple, related motor programs during learning.
M3 - SCORING: Journal article
VL - 484
SP - 473
EP - 478
JO - NATURE
JF - NATURE
SN - 0028-0836
IS - 7395
M1 - 7395
ER -
