Multiorgan tropism of SARS-CoV-2 lineage B.1.1.7
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Multiorgan tropism of SARS-CoV-2 lineage B.1.1.7. / Ondruschka, Benjamin; Heinrich, Fabian; Lindenmeyer, Maja; Edler, Carolin; Möbius, Dustin; Czogalla, Jan; Heinemann, Axel; Braun, Fabian; Aepfelbacher, Martin; Lütgehetmann, Marc; Huber, Tobias B.
in: INT J LEGAL MED, Jahrgang 135, Nr. 6, 11.2021, S. 2347-2349.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Multiorgan tropism of SARS-CoV-2 lineage B.1.1.7
AU - Ondruschka, Benjamin
AU - Heinrich, Fabian
AU - Lindenmeyer, Maja
AU - Edler, Carolin
AU - Möbius, Dustin
AU - Czogalla, Jan
AU - Heinemann, Axel
AU - Braun, Fabian
AU - Aepfelbacher, Martin
AU - Lütgehetmann, Marc
AU - Huber, Tobias B
N1 - © 2021. The Author(s).
PY - 2021/11
Y1 - 2021/11
N2 - Due to the development of novel functionalities, distinct SARS-CoV-2 variants such as B.1.1.7 fuel the current pandemic. B.1.1.7 is not only more transmissible, but may also cause an increased mortality compared to previous SARS-CoV-2 variants. Human tissue analysis of the SARS-CoV-2 lineage B.1.1.7 is urgently needed, and we here present autopsy data from 7 consecutive SARS-CoV-2 B.1.1.7 cases. The initial RT-qPCR analyses from nasopharyngeal swabs taken post mortem included typing assays for B.1.1.7. We quantitated SARS-CoV-2 B.1.1.7 viral load in autopsy tissue of multiple organs. Highest levels of SARS-CoV-2 B.1.1.7 copies normalized to ß-globin were detected in the respiratory system (lung and pharynx), followed by the liver and heart. Importantly, SARS-CoV-2 lineage B.1.1.7 was found in 100% of cases in the lungs and in 85.7% in pharynx tissue. Detection also in the kidney and brain highlighting a pronounced organ tropism. Comparison of the given results to a former cohort of SARS-CoV-2 deaths during the first wave in spring 2020 showed resembling organ tropism. Our results indicate that also SARS-CoV-2 B.1.1.7 has a relevant organ tropism beyond the respiratory tract. We speculate that B.1.1.7 spike protein's affinity to human ACE2 facilitates transmission, organ tropism, and ultimately morbidity and mortality. Further studies and larger cohorts are obligatory to proof this link.
AB - Due to the development of novel functionalities, distinct SARS-CoV-2 variants such as B.1.1.7 fuel the current pandemic. B.1.1.7 is not only more transmissible, but may also cause an increased mortality compared to previous SARS-CoV-2 variants. Human tissue analysis of the SARS-CoV-2 lineage B.1.1.7 is urgently needed, and we here present autopsy data from 7 consecutive SARS-CoV-2 B.1.1.7 cases. The initial RT-qPCR analyses from nasopharyngeal swabs taken post mortem included typing assays for B.1.1.7. We quantitated SARS-CoV-2 B.1.1.7 viral load in autopsy tissue of multiple organs. Highest levels of SARS-CoV-2 B.1.1.7 copies normalized to ß-globin were detected in the respiratory system (lung and pharynx), followed by the liver and heart. Importantly, SARS-CoV-2 lineage B.1.1.7 was found in 100% of cases in the lungs and in 85.7% in pharynx tissue. Detection also in the kidney and brain highlighting a pronounced organ tropism. Comparison of the given results to a former cohort of SARS-CoV-2 deaths during the first wave in spring 2020 showed resembling organ tropism. Our results indicate that also SARS-CoV-2 B.1.1.7 has a relevant organ tropism beyond the respiratory tract. We speculate that B.1.1.7 spike protein's affinity to human ACE2 facilitates transmission, organ tropism, and ultimately morbidity and mortality. Further studies and larger cohorts are obligatory to proof this link.
U2 - 10.1007/s00414-021-02691-z
DO - 10.1007/s00414-021-02691-z
M3 - SCORING: Journal article
C2 - 34486072
VL - 135
SP - 2347
EP - 2349
JO - INT J LEGAL MED
JF - INT J LEGAL MED
SN - 0937-9827
IS - 6
ER -
