Multi-omics approaches to study platelet mechanisms

Fiorella A Solari; Daniel Krahn; Frauke Swieringa; Steven Verhelst; Tienush Rassaf; Alpaslan Tasdogan; Rene P Zahedi; Kristina Lorenz; Thomas Renné; Johan W M Heemskerk; Albert Sickmann

doi:10.1016/j.cbpa.2022.102253

Multi-omics approaches to study platelet mechanisms

Standard

Multi-omics approaches to study platelet mechanisms. / Solari, Fiorella A; Krahn, Daniel; Swieringa, Frauke; Verhelst, Steven; Rassaf, Tienush; Tasdogan, Alpaslan; Zahedi, Rene P; Lorenz, Kristina; Renné, Thomas; Heemskerk, Johan W M; Sickmann, Albert.

in: CURR OPIN CHEM BIOL, Jahrgang 73, 04.2023, S. 102253.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Solari, FA, Krahn, D, Swieringa, F, Verhelst, S, Rassaf, T, Tasdogan, A, Zahedi, RP, Lorenz, K, Renné, T, Heemskerk, JWM & Sickmann, A 2023, 'Multi-omics approaches to study platelet mechanisms', CURR OPIN CHEM BIOL, Jg. 73, S. 102253. https://doi.org/10.1016/j.cbpa.2022.102253

APA

Solari, F. A., Krahn, D., Swieringa, F., Verhelst, S., Rassaf, T., Tasdogan, A., Zahedi, R. P., Lorenz, K., Renné, T., Heemskerk, J. W. M., & Sickmann, A. (2023). Multi-omics approaches to study platelet mechanisms. CURR OPIN CHEM BIOL, 73, 102253. https://doi.org/10.1016/j.cbpa.2022.102253

Vancouver

Solari FA, Krahn D, Swieringa F, Verhelst S, Rassaf T, Tasdogan A et al. Multi-omics approaches to study platelet mechanisms. CURR OPIN CHEM BIOL. 2023 Apr;73:102253. https://doi.org/10.1016/j.cbpa.2022.102253

Bibtex

@article{f295b5c798f24aae8e05b5400cddce73,

title = "Multi-omics approaches to study platelet mechanisms",

abstract = "Platelets are small anucleate cell fragments (2-4 μm in diameter) in the blood, which play an essential role in thrombosis and hemostasis. Genetic or acquired platelet dysfunctions are linked to bleeding, increased risk of thromboembolic events and cardiovascular diseases. Advanced proteomic approaches may pave the way to a better understanding of the roles of platelets in hemostasis, and pathophysiological processes such as inflammation, metastatic spread and thrombosis. Further insights into the molecular biology of platelets are crucial to aid drug development and identify diagnostic markers of platelet activation. Platelet activation is known to be an extremely rapid process and involves multiple post-translational mechanisms at sub second time scale, including proteolysis and phosphorylation. Multi-omics technologies and biochemical approaches can be exploited to precisely probe and define these posttranslational pathways. Notably, the absence of a nucleus in platelets significantly reduces the number of present proteins, simplifying mass spectrometry-based proteomics and metabolomics approaches.",

author = "Solari, {Fiorella A} and Daniel Krahn and Frauke Swieringa and Steven Verhelst and Tienush Rassaf and Alpaslan Tasdogan and Zahedi, {Rene P} and Kristina Lorenz and Thomas Renn{\'e} and Heemskerk, {Johan W M} and Albert Sickmann",

year = "2023",

month = apr,

doi = "10.1016/j.cbpa.2022.102253",

language = "English",

volume = "73",

pages = "102253",

journal = "CURR OPIN CHEM BIOL",

issn = "1367-5931",

publisher = "Elsevier Limited",

}

RIS

TY - JOUR

T1 - Multi-omics approaches to study platelet mechanisms

AU - Solari, Fiorella A

AU - Krahn, Daniel

AU - Swieringa, Frauke

AU - Verhelst, Steven

AU - Rassaf, Tienush

AU - Tasdogan, Alpaslan

AU - Zahedi, Rene P

AU - Lorenz, Kristina

AU - Renné, Thomas

AU - Heemskerk, Johan W M

AU - Sickmann, Albert

PY - 2023/4

Y1 - 2023/4

N2 - Platelets are small anucleate cell fragments (2-4 μm in diameter) in the blood, which play an essential role in thrombosis and hemostasis. Genetic or acquired platelet dysfunctions are linked to bleeding, increased risk of thromboembolic events and cardiovascular diseases. Advanced proteomic approaches may pave the way to a better understanding of the roles of platelets in hemostasis, and pathophysiological processes such as inflammation, metastatic spread and thrombosis. Further insights into the molecular biology of platelets are crucial to aid drug development and identify diagnostic markers of platelet activation. Platelet activation is known to be an extremely rapid process and involves multiple post-translational mechanisms at sub second time scale, including proteolysis and phosphorylation. Multi-omics technologies and biochemical approaches can be exploited to precisely probe and define these posttranslational pathways. Notably, the absence of a nucleus in platelets significantly reduces the number of present proteins, simplifying mass spectrometry-based proteomics and metabolomics approaches.

AB - Platelets are small anucleate cell fragments (2-4 μm in diameter) in the blood, which play an essential role in thrombosis and hemostasis. Genetic or acquired platelet dysfunctions are linked to bleeding, increased risk of thromboembolic events and cardiovascular diseases. Advanced proteomic approaches may pave the way to a better understanding of the roles of platelets in hemostasis, and pathophysiological processes such as inflammation, metastatic spread and thrombosis. Further insights into the molecular biology of platelets are crucial to aid drug development and identify diagnostic markers of platelet activation. Platelet activation is known to be an extremely rapid process and involves multiple post-translational mechanisms at sub second time scale, including proteolysis and phosphorylation. Multi-omics technologies and biochemical approaches can be exploited to precisely probe and define these posttranslational pathways. Notably, the absence of a nucleus in platelets significantly reduces the number of present proteins, simplifying mass spectrometry-based proteomics and metabolomics approaches.

U2 - 10.1016/j.cbpa.2022.102253

DO - 10.1016/j.cbpa.2022.102253

M3 - SCORING: Review article

C2 - 36689818

VL - 73

SP - 102253

JO - CURR OPIN CHEM BIOL

JF - CURR OPIN CHEM BIOL

SN - 1367-5931

ER -