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Multi-institutional validation of the prognostic value of Ki-67 labeling index in patients treated with radical prostatectomy

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Multi-institutional validation of the prognostic value of Ki-67 labeling index in patients treated with radical prostatectomy. / Mathieu, Romain; Shariat, Shahrokh F; Seitz, Christian; Karakiewicz, Pierre I; Fajkovic, Harun; Sun, Maxine; Lotan, Yair; Scherr, Douglas S; Tewari, Ashutosh; Montorsi, Francesco; Briganti, Alberto; Rouprêt, Morgan; Lucca, Ilaria; Margulis, Vitaly; Rink, Michael; Kluth, Luis A; Rieken, Malte; Bachman, Alexander; Xylinas, Evanguelos; Robinson, Brian D; Bensalah, Karim; Margreiter, Markus.

in: WORLD J UROL, Jahrgang 33, Nr. 8, 08.2015, S. 1165-1171.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Mathieu, R, Shariat, SF, Seitz, C, Karakiewicz, PI, Fajkovic, H, Sun, M, Lotan, Y, Scherr, DS, Tewari, A, Montorsi, F, Briganti, A, Rouprêt, M, Lucca, I, Margulis, V, Rink, M, Kluth, LA, Rieken, M, Bachman, A, Xylinas, E, Robinson, BD, Bensalah, K & Margreiter, M 2015, 'Multi-institutional validation of the prognostic value of Ki-67 labeling index in patients treated with radical prostatectomy', WORLD J UROL, Jg. 33, Nr. 8, S. 1165-1171. https://doi.org/10.1007/s00345-014-1421-3

APA

Mathieu, R., Shariat, S. F., Seitz, C., Karakiewicz, P. I., Fajkovic, H., Sun, M., Lotan, Y., Scherr, D. S., Tewari, A., Montorsi, F., Briganti, A., Rouprêt, M., Lucca, I., Margulis, V., Rink, M., Kluth, L. A., Rieken, M., Bachman, A., Xylinas, E., ... Margreiter, M. (2015). Multi-institutional validation of the prognostic value of Ki-67 labeling index in patients treated with radical prostatectomy. WORLD J UROL, 33(8), 1165-1171. https://doi.org/10.1007/s00345-014-1421-3

Vancouver

Mathieu R, Shariat SF, Seitz C, Karakiewicz PI, Fajkovic H, Sun M et al. Multi-institutional validation of the prognostic value of Ki-67 labeling index in patients treated with radical prostatectomy. WORLD J UROL. 2015 Aug;33(8):1165-1171. https://doi.org/10.1007/s00345-014-1421-3

Bibtex

@article{efb38f6ab073419f90a5f2ec08e4c843,
title = "Multi-institutional validation of the prognostic value of Ki-67 labeling index in patients treated with radical prostatectomy",
abstract = "OBJECTIVE: Several smaller single-center studies have reported a prognostic role for Ki-67 labeling index in prostate cancer. Our aim was to test whether Ki-67 is an independent prognostic marker of biochemical recurrence (BCR) in a large international cohort of patients treated with radical prostatectomy (RP).METHODS: Ki-67 immunohistochemical staining on prostatectomy specimens from 3,123 patients who underwent RP for prostate cancer was retrospectively performed. Univariable and multivariable Cox regression models were used to assess the association of Ki-67 status with BCR.RESULTS: Ki-67 positive status was observed in 762 (24.4 %) patients and was associated with lymph node involvement (LNI) (p = 0.039). Six hundred and twenty-one (19.9 %) patients experienced BCR. The estimated 3-year biochemical-free survivals were 85 % for patients with negative Ki-67 status and 82.1 % for patients with positive Ki-67 status (log-rank test, p = 0.014). In multivariable analysis that adjusted for the effects of age, preoperative PSA, RP Gleason sum, seminal vesicle invasion, extracapsular extension, positive surgical margins, lymphovascular invasion, and LNI, Ki-67 was significantly associated with BCR (HR = 1.19; p = 0.019). Subgroup analysis revealed that Ki-67 is associated with BCR in patients without LNI (p = 0.004), those with RP Gleason sum 7 (p = 0.015), and those with negative surgical margins (p = 0.047).CONCLUSION: We confirmed Ki-67 as an independent predictor of BCR after RP. Ki-67 could be particularly informative in patients with favorable pathologic characteristics to help in the clinical decision-making regarding adjuvant therapy and optimized follow-up scheduling.",
author = "Romain Mathieu and Shariat, {Shahrokh F} and Christian Seitz and Karakiewicz, {Pierre I} and Harun Fajkovic and Maxine Sun and Yair Lotan and Scherr, {Douglas S} and Ashutosh Tewari and Francesco Montorsi and Alberto Briganti and Morgan Roupr{\^e}t and Ilaria Lucca and Vitaly Margulis and Michael Rink and Kluth, {Luis A} and Malte Rieken and Alexander Bachman and Evanguelos Xylinas and Robinson, {Brian D} and Karim Bensalah and Markus Margreiter",
year = "2015",
month = aug,
doi = "10.1007/s00345-014-1421-3",
language = "English",
volume = "33",
pages = "1165--1171",
journal = "WORLD J UROL",
issn = "0724-4983",
publisher = "Springer",
number = "8",

}

RIS

TY - JOUR

T1 - Multi-institutional validation of the prognostic value of Ki-67 labeling index in patients treated with radical prostatectomy

AU - Mathieu, Romain

AU - Shariat, Shahrokh F

AU - Seitz, Christian

AU - Karakiewicz, Pierre I

AU - Fajkovic, Harun

AU - Sun, Maxine

AU - Lotan, Yair

AU - Scherr, Douglas S

AU - Tewari, Ashutosh

AU - Montorsi, Francesco

AU - Briganti, Alberto

AU - Rouprêt, Morgan

AU - Lucca, Ilaria

AU - Margulis, Vitaly

AU - Rink, Michael

AU - Kluth, Luis A

AU - Rieken, Malte

AU - Bachman, Alexander

AU - Xylinas, Evanguelos

AU - Robinson, Brian D

AU - Bensalah, Karim

AU - Margreiter, Markus

PY - 2015/8

Y1 - 2015/8

N2 - OBJECTIVE: Several smaller single-center studies have reported a prognostic role for Ki-67 labeling index in prostate cancer. Our aim was to test whether Ki-67 is an independent prognostic marker of biochemical recurrence (BCR) in a large international cohort of patients treated with radical prostatectomy (RP).METHODS: Ki-67 immunohistochemical staining on prostatectomy specimens from 3,123 patients who underwent RP for prostate cancer was retrospectively performed. Univariable and multivariable Cox regression models were used to assess the association of Ki-67 status with BCR.RESULTS: Ki-67 positive status was observed in 762 (24.4 %) patients and was associated with lymph node involvement (LNI) (p = 0.039). Six hundred and twenty-one (19.9 %) patients experienced BCR. The estimated 3-year biochemical-free survivals were 85 % for patients with negative Ki-67 status and 82.1 % for patients with positive Ki-67 status (log-rank test, p = 0.014). In multivariable analysis that adjusted for the effects of age, preoperative PSA, RP Gleason sum, seminal vesicle invasion, extracapsular extension, positive surgical margins, lymphovascular invasion, and LNI, Ki-67 was significantly associated with BCR (HR = 1.19; p = 0.019). Subgroup analysis revealed that Ki-67 is associated with BCR in patients without LNI (p = 0.004), those with RP Gleason sum 7 (p = 0.015), and those with negative surgical margins (p = 0.047).CONCLUSION: We confirmed Ki-67 as an independent predictor of BCR after RP. Ki-67 could be particularly informative in patients with favorable pathologic characteristics to help in the clinical decision-making regarding adjuvant therapy and optimized follow-up scheduling.

AB - OBJECTIVE: Several smaller single-center studies have reported a prognostic role for Ki-67 labeling index in prostate cancer. Our aim was to test whether Ki-67 is an independent prognostic marker of biochemical recurrence (BCR) in a large international cohort of patients treated with radical prostatectomy (RP).METHODS: Ki-67 immunohistochemical staining on prostatectomy specimens from 3,123 patients who underwent RP for prostate cancer was retrospectively performed. Univariable and multivariable Cox regression models were used to assess the association of Ki-67 status with BCR.RESULTS: Ki-67 positive status was observed in 762 (24.4 %) patients and was associated with lymph node involvement (LNI) (p = 0.039). Six hundred and twenty-one (19.9 %) patients experienced BCR. The estimated 3-year biochemical-free survivals were 85 % for patients with negative Ki-67 status and 82.1 % for patients with positive Ki-67 status (log-rank test, p = 0.014). In multivariable analysis that adjusted for the effects of age, preoperative PSA, RP Gleason sum, seminal vesicle invasion, extracapsular extension, positive surgical margins, lymphovascular invasion, and LNI, Ki-67 was significantly associated with BCR (HR = 1.19; p = 0.019). Subgroup analysis revealed that Ki-67 is associated with BCR in patients without LNI (p = 0.004), those with RP Gleason sum 7 (p = 0.015), and those with negative surgical margins (p = 0.047).CONCLUSION: We confirmed Ki-67 as an independent predictor of BCR after RP. Ki-67 could be particularly informative in patients with favorable pathologic characteristics to help in the clinical decision-making regarding adjuvant therapy and optimized follow-up scheduling.

U2 - 10.1007/s00345-014-1421-3

DO - 10.1007/s00345-014-1421-3

M3 - SCORING: Journal article

C2 - 25344896

VL - 33

SP - 1165

EP - 1171

JO - WORLD J UROL

JF - WORLD J UROL

SN - 0724-4983

IS - 8

ER -