Multi-ethnic genome-wide association study for atrial fibrillation
Standard
Multi-ethnic genome-wide association study for atrial fibrillation. / Roselli, Carolina; Chaffin, Mark D; Weng, Lu-Chen; Aeschbacher, Stefanie; Ahlberg, Gustav; Albert, Christine M; Almgren, Peter; Alonso, Alvaro; Anderson, Christopher D; Aragam, Krishna G; Arking, Dan E; Barnard, John; Bartz, Traci M; Benjamin, Emelia J; Bihlmeyer, Nathan A; Bis, Joshua C; Bloom, Heather L; Boerwinkle, Eric; Bottinger, Erwin B; Brody, Jennifer A; Calkins, Hugh; Campbell, Archie; Cappola, Thomas P; Carlquist, John; Chasman, Daniel I; Chen, Lin Y; Chen, Yii-Der Ida; Choi, Eue-Keun; Choi, Seung Hoan; Christophersen, Ingrid E; Chung, Mina K; Cole, John W; Conen, David; Cook, James; Crijns, Harry J; Cutler, Michael J; Damrauer, Scott M; Daniels, Brian R; Darbar, Dawood; Delgado, Graciela; Denny, Joshua C; Dichgans, Martin; Dörr, Marcus; Dudink, Elton A; Dudley, Samuel C; Esa, Nada; Esko, Tonu; Eskola, Markku; Fatkin, Diane; Felix, Stephan B; Ford, Ian; Franco, Oscar H; Geelhoed, Bastiaan; Grewal, Raji P; Gudnason, Vilmundur; Guo, Xiuqing; Gupta, Namrata; Gustafsson, Stefan; Gutmann, Rebecca; Hamsten, Anders; Harris, Tamara B; Hayward, Caroline; Heckbert, Susan R; Hernesniemi, Jussi; Hocking, Lynne J; Hofman, Albert; Horimoto, Andrea R V R; Huang, Jie; Huang, Paul L; Huffman, Jennifer; Ingelsson, Erik; Ipek, Esra Gucuk; Ito, Kaoru; Jimenez-Conde, Jordi; Johnson, Renee; Jukema, J Wouter; Kääb, Stefan; Kähönen, Mika; Kamatani, Yoichiro; Kane, John P; Kastrati, Adnan; Kathiresan, Sekar; Katschnig-Winter, Petra; Kavousi, Maryam; Kessler, Thorsten; Kietselaer, Bas L; Kirchhof, Paulus; Kleber, Marcus E; Knight, Stacey; Krieger, Jose E; Kubo, Michiaki; Launer, Lenore J; Laurikka, Jari; Lehtimäki, Terho; Leineweber, Kirsten; Lemaitre, Rozenn N; Li, Man; Lim, Hong Euy; Lin, Henry J; Lin, Honghuang; Lind, Lars; Lindgren, Cecilia M; Lokki, Marja-Liisa; London, Barry; Loos, Ruth J F; Low, Siew-Kee; Lu, Yingchang; Lyytikäinen, Leo-Pekka; Macfarlane, Peter W; Magnusson, Patrik K; Mahajan, Anubha; Malik, Rainer; Mansur, Alfredo J; Marcus, Gregory M; Margolin, Lauren; Margulies, Kenneth B; März, Winfried; McManus, David D; Melander, Olle; Mohanty, Sanghamitra; Montgomery, Jay A; Morley, Michael P; Morris, Andrew P; Müller-Nurasyid, Martina; Natale, Andrea; Nazarian, Saman; Neumann, Benjamin; Newton-Cheh, Christopher; Niemeijer, Maartje N; Nikus, Kjell; Nilsson, Peter; Noordam, Raymond; Oellers, Heidi; Olesen, Morten S; Orho-Melander, Marju; Padmanabhan, Sandosh; Pak, Hui-Nam; Paré, Guillaume; Pedersen, Nancy L; Pera, Joanna; Pereira, Alexandre; Porteous, David; Psaty, Bruce M; Pulit, Sara L; Pullinger, Clive R; Rader, Daniel J; Refsgaard, Lena; Ribasés, Marta; Ridker, Paul M; Rienstra, Michiel; Risch, Lorenz; Roden, Dan M; Rosand, Jonathan; Rosenberg, Michael A; Rost, Natalia; Rotter, Jerome I; Saba, Samir; Sandhu, Roopinder K; Schnabel, Renate B; Schramm, Katharina; Schunkert, Heribert; Schurman, Claudia; Scott, Stuart A; Seppälä, Ilkka; Shaffer, Christian; Shah, Svati; Shalaby, Alaa A; Shim, Jaemin; Shoemaker, M Benjamin; Siland, Joylene E; Sinisalo, Juha; Sinner, Moritz F; Slowik, Agnieszka; Smith, Albert V; Smith, Blair H; Smith, J Gustav; Smith, Jonathan D; Smith, Nicholas L; Soliman, Elsayed Z; Sotoodehnia, Nona; Stricker, Bruno H; Sun, Albert; Sun, Han; Svendsen, Jesper H; Tanaka, Toshihiro; Tanriverdi, Kahraman; Taylor, Kent D; Teder-Laving, Maris; Teumer, Alexander; Thériault, Sébastien; Trompet, Stella; Tucker, Nathan R; Tveit, Arnljot; Uitterlinden, Andre G; Van Der Harst, Pim; Van Gelder, Isabelle C; Van Wagoner, David R; Verweij, Niek; Vlachopoulou, Efthymia; Völker, Uwe; Wang, Biqi; Weeke, Peter E; Weijs, Bob; Weiss, Raul; Weiss, Stefan; Wells, Quinn S; Wiggins, Kerri L; Wong, Jorge A; Woo, Daniel; Worrall, Bradford B; Yang, Pil-Sung; Yao, Jie; Yoneda, Zachary T; Zeller, Tanja; Zeng, Lingyao; Lubitz, Steven A; Lunetta, Kathryn L; Ellinor, Patrick T.
in: NAT GENET, Jahrgang 50, Nr. 9, 11.06.2018, S. 1225-1233.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Multi-ethnic genome-wide association study for atrial fibrillation
AU - Roselli, Carolina
AU - Chaffin, Mark D
AU - Weng, Lu-Chen
AU - Aeschbacher, Stefanie
AU - Ahlberg, Gustav
AU - Albert, Christine M
AU - Almgren, Peter
AU - Alonso, Alvaro
AU - Anderson, Christopher D
AU - Aragam, Krishna G
AU - Arking, Dan E
AU - Barnard, John
AU - Bartz, Traci M
AU - Benjamin, Emelia J
AU - Bihlmeyer, Nathan A
AU - Bis, Joshua C
AU - Bloom, Heather L
AU - Boerwinkle, Eric
AU - Bottinger, Erwin B
AU - Brody, Jennifer A
AU - Calkins, Hugh
AU - Campbell, Archie
AU - Cappola, Thomas P
AU - Carlquist, John
AU - Chasman, Daniel I
AU - Chen, Lin Y
AU - Chen, Yii-Der Ida
AU - Choi, Eue-Keun
AU - Choi, Seung Hoan
AU - Christophersen, Ingrid E
AU - Chung, Mina K
AU - Cole, John W
AU - Conen, David
AU - Cook, James
AU - Crijns, Harry J
AU - Cutler, Michael J
AU - Damrauer, Scott M
AU - Daniels, Brian R
AU - Darbar, Dawood
AU - Delgado, Graciela
AU - Denny, Joshua C
AU - Dichgans, Martin
AU - Dörr, Marcus
AU - Dudink, Elton A
AU - Dudley, Samuel C
AU - Esa, Nada
AU - Esko, Tonu
AU - Eskola, Markku
AU - Fatkin, Diane
AU - Felix, Stephan B
AU - Ford, Ian
AU - Franco, Oscar H
AU - Geelhoed, Bastiaan
AU - Grewal, Raji P
AU - Gudnason, Vilmundur
AU - Guo, Xiuqing
AU - Gupta, Namrata
AU - Gustafsson, Stefan
AU - Gutmann, Rebecca
AU - Hamsten, Anders
AU - Harris, Tamara B
AU - Hayward, Caroline
AU - Heckbert, Susan R
AU - Hernesniemi, Jussi
AU - Hocking, Lynne J
AU - Hofman, Albert
AU - Horimoto, Andrea R V R
AU - Huang, Jie
AU - Huang, Paul L
AU - Huffman, Jennifer
AU - Ingelsson, Erik
AU - Ipek, Esra Gucuk
AU - Ito, Kaoru
AU - Jimenez-Conde, Jordi
AU - Johnson, Renee
AU - Jukema, J Wouter
AU - Kääb, Stefan
AU - Kähönen, Mika
AU - Kamatani, Yoichiro
AU - Kane, John P
AU - Kastrati, Adnan
AU - Kathiresan, Sekar
AU - Katschnig-Winter, Petra
AU - Kavousi, Maryam
AU - Kessler, Thorsten
AU - Kietselaer, Bas L
AU - Kirchhof, Paulus
AU - Kleber, Marcus E
AU - Knight, Stacey
AU - Krieger, Jose E
AU - Kubo, Michiaki
AU - Launer, Lenore J
AU - Laurikka, Jari
AU - Lehtimäki, Terho
AU - Leineweber, Kirsten
AU - Lemaitre, Rozenn N
AU - Li, Man
AU - Lim, Hong Euy
AU - Lin, Henry J
AU - Lin, Honghuang
AU - Lind, Lars
AU - Lindgren, Cecilia M
AU - Lokki, Marja-Liisa
AU - London, Barry
AU - Loos, Ruth J F
AU - Low, Siew-Kee
AU - Lu, Yingchang
AU - Lyytikäinen, Leo-Pekka
AU - Macfarlane, Peter W
AU - Magnusson, Patrik K
AU - Mahajan, Anubha
AU - Malik, Rainer
AU - Mansur, Alfredo J
AU - Marcus, Gregory M
AU - Margolin, Lauren
AU - Margulies, Kenneth B
AU - März, Winfried
AU - McManus, David D
AU - Melander, Olle
AU - Mohanty, Sanghamitra
AU - Montgomery, Jay A
AU - Morley, Michael P
AU - Morris, Andrew P
AU - Müller-Nurasyid, Martina
AU - Natale, Andrea
AU - Nazarian, Saman
AU - Neumann, Benjamin
AU - Newton-Cheh, Christopher
AU - Niemeijer, Maartje N
AU - Nikus, Kjell
AU - Nilsson, Peter
AU - Noordam, Raymond
AU - Oellers, Heidi
AU - Olesen, Morten S
AU - Orho-Melander, Marju
AU - Padmanabhan, Sandosh
AU - Pak, Hui-Nam
AU - Paré, Guillaume
AU - Pedersen, Nancy L
AU - Pera, Joanna
AU - Pereira, Alexandre
AU - Porteous, David
AU - Psaty, Bruce M
AU - Pulit, Sara L
AU - Pullinger, Clive R
AU - Rader, Daniel J
AU - Refsgaard, Lena
AU - Ribasés, Marta
AU - Ridker, Paul M
AU - Rienstra, Michiel
AU - Risch, Lorenz
AU - Roden, Dan M
AU - Rosand, Jonathan
AU - Rosenberg, Michael A
AU - Rost, Natalia
AU - Rotter, Jerome I
AU - Saba, Samir
AU - Sandhu, Roopinder K
AU - Schnabel, Renate B
AU - Schramm, Katharina
AU - Schunkert, Heribert
AU - Schurman, Claudia
AU - Scott, Stuart A
AU - Seppälä, Ilkka
AU - Shaffer, Christian
AU - Shah, Svati
AU - Shalaby, Alaa A
AU - Shim, Jaemin
AU - Shoemaker, M Benjamin
AU - Siland, Joylene E
AU - Sinisalo, Juha
AU - Sinner, Moritz F
AU - Slowik, Agnieszka
AU - Smith, Albert V
AU - Smith, Blair H
AU - Smith, J Gustav
AU - Smith, Jonathan D
AU - Smith, Nicholas L
AU - Soliman, Elsayed Z
AU - Sotoodehnia, Nona
AU - Stricker, Bruno H
AU - Sun, Albert
AU - Sun, Han
AU - Svendsen, Jesper H
AU - Tanaka, Toshihiro
AU - Tanriverdi, Kahraman
AU - Taylor, Kent D
AU - Teder-Laving, Maris
AU - Teumer, Alexander
AU - Thériault, Sébastien
AU - Trompet, Stella
AU - Tucker, Nathan R
AU - Tveit, Arnljot
AU - Uitterlinden, Andre G
AU - Van Der Harst, Pim
AU - Van Gelder, Isabelle C
AU - Van Wagoner, David R
AU - Verweij, Niek
AU - Vlachopoulou, Efthymia
AU - Völker, Uwe
AU - Wang, Biqi
AU - Weeke, Peter E
AU - Weijs, Bob
AU - Weiss, Raul
AU - Weiss, Stefan
AU - Wells, Quinn S
AU - Wiggins, Kerri L
AU - Wong, Jorge A
AU - Woo, Daniel
AU - Worrall, Bradford B
AU - Yang, Pil-Sung
AU - Yao, Jie
AU - Yoneda, Zachary T
AU - Zeller, Tanja
AU - Zeng, Lingyao
AU - Lubitz, Steven A
AU - Lunetta, Kathryn L
AU - Ellinor, Patrick T
PY - 2018/6/11
Y1 - 2018/6/11
N2 - Atrial fibrillation (AF) affects more than 33 million individuals worldwide1 and has a complex heritability2. We conducted the largest meta-analysis of genome-wide association studies (GWAS) for AF to date, consisting of more than half a million individuals, including 65,446 with AF. In total, we identified 97 loci significantly associated with AF, including 67 that were novel in a combined-ancestry analysis, and 3 that were novel in a European-specific analysis. We sought to identify AF-associated genes at the GWAS loci by performing RNA-sequencing and expression quantitative trait locus analyses in 101 left atrial samples, the most relevant tissue for AF. We also performed transcriptome-wide analyses that identified 57 AF-associated genes, 42 of which overlap with GWAS loci. The identified loci implicate genes enriched within cardiac developmental, electrophysiological, contractile and structural pathways. These results extend our understanding of the biological pathways underlying AF and may facilitate the development of therapeutics for AF.
AB - Atrial fibrillation (AF) affects more than 33 million individuals worldwide1 and has a complex heritability2. We conducted the largest meta-analysis of genome-wide association studies (GWAS) for AF to date, consisting of more than half a million individuals, including 65,446 with AF. In total, we identified 97 loci significantly associated with AF, including 67 that were novel in a combined-ancestry analysis, and 3 that were novel in a European-specific analysis. We sought to identify AF-associated genes at the GWAS loci by performing RNA-sequencing and expression quantitative trait locus analyses in 101 left atrial samples, the most relevant tissue for AF. We also performed transcriptome-wide analyses that identified 57 AF-associated genes, 42 of which overlap with GWAS loci. The identified loci implicate genes enriched within cardiac developmental, electrophysiological, contractile and structural pathways. These results extend our understanding of the biological pathways underlying AF and may facilitate the development of therapeutics for AF.
KW - Atrial Fibrillation/ethnology
KW - Case-Control Studies
KW - Ethnic Groups/genetics
KW - Genetic Predisposition to Disease
KW - Genome-Wide Association Study/methods
KW - Humans
KW - Quantitative Trait Loci
KW - Transcriptome
U2 - 10.1038/s41588-018-0133-9
DO - 10.1038/s41588-018-0133-9
M3 - SCORING: Journal article
C2 - 29892015
VL - 50
SP - 1225
EP - 1233
JO - NAT GENET
JF - NAT GENET
SN - 1061-4036
IS - 9
ER -