Multicontrast-weighted magnetic resonance imaging of atherosclerotic plaques at 3.0 and 1.5 Tesla: ex-vivo comparison with histopathologic correlation.
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Multicontrast-weighted magnetic resonance imaging of atherosclerotic plaques at 3.0 and 1.5 Tesla: ex-vivo comparison with histopathologic correlation. / Koops, Andreas; Ittrich, Harald; Petri, Susan; Priest, Andrew; Stork, Alexander; Lockemann, Ute; Adam, Gerhard; Weber, Christoph.
in: EUR RADIOL, Jahrgang 17, Nr. 1, 1, 01.01.2007, S. 279-286.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Multicontrast-weighted magnetic resonance imaging of atherosclerotic plaques at 3.0 and 1.5 Tesla: ex-vivo comparison with histopathologic correlation.
AU - Koops, Andreas
AU - Ittrich, Harald
AU - Petri, Susan
AU - Priest, Andrew
AU - Stork, Alexander
AU - Lockemann, Ute
AU - Adam, Gerhard
AU - Weber, Christoph
PY - 2007/1/1
Y1 - 2007/1/1
N2 - The purpose was to analyze magnetic resonance (MR) plaque imaging at 3.0 Tesla and 1.5 Tesla in correlation with histopathology. MR imaging (MRI) of the abdominal aorta and femoral artery was performed on seven corpses using T1-weighted, T2-weighted, and PD-weighted sequences at 3.0 and 1.5 Tesla. Cross-sectional images at the branching of the inferior mesenteric artery and the profunda femoris were rated with respect to image quality. Corresponding cross sections of the imaged vessels were obtained at autopsy. The atherosclerotic plaques in the histological slides and MR images were classified according to the American Heart Association (AHA) and analyzed for differences. MRI at 3.0 Tesla offered superior depiction of arterial wall composition in all contrast weightings, rated best for T2-weighted images. Comparing for field strength, the highest differences were observed in T1-weighted and T2-weighted techniques (both P<or =0.001), with still significant differences in PD-weighted sequence (P<or =0.005). The majority of plaques were histologically classified as calcified plaques. In up to 21% of the cases, MRI at both field strengths detected signal loss characteristic of calcification although calcified plaque was absent in histology. MRI at 3.0 Tesla offers superior plaque imaging quality compared with 1.5 Tesla, but further work is necessary to determine whether this translates in superior diagnostic accuracy.
AB - The purpose was to analyze magnetic resonance (MR) plaque imaging at 3.0 Tesla and 1.5 Tesla in correlation with histopathology. MR imaging (MRI) of the abdominal aorta and femoral artery was performed on seven corpses using T1-weighted, T2-weighted, and PD-weighted sequences at 3.0 and 1.5 Tesla. Cross-sectional images at the branching of the inferior mesenteric artery and the profunda femoris were rated with respect to image quality. Corresponding cross sections of the imaged vessels were obtained at autopsy. The atherosclerotic plaques in the histological slides and MR images were classified according to the American Heart Association (AHA) and analyzed for differences. MRI at 3.0 Tesla offered superior depiction of arterial wall composition in all contrast weightings, rated best for T2-weighted images. Comparing for field strength, the highest differences were observed in T1-weighted and T2-weighted techniques (both P<or =0.001), with still significant differences in PD-weighted sequence (P<or =0.005). The majority of plaques were histologically classified as calcified plaques. In up to 21% of the cases, MRI at both field strengths detected signal loss characteristic of calcification although calcified plaque was absent in histology. MRI at 3.0 Tesla offers superior plaque imaging quality compared with 1.5 Tesla, but further work is necessary to determine whether this translates in superior diagnostic accuracy.
KW - Aged
KW - Aged, 80 and over
KW - Aorta, Abdominal
KW - Aortic Diseases
KW - Atherosclerosis
KW - Cadaver
KW - Female
KW - Femoral Artery
KW - Humans
KW - Magnetic Resonance Imaging
KW - Male
KW - Middle Aged
U2 - 10.1007/s00330-006-0265-7
DO - 10.1007/s00330-006-0265-7
M3 - SCORING: Journal article
C2 - 16642325
VL - 17
SP - 279
EP - 286
JO - EUR RADIOL
JF - EUR RADIOL
SN - 0938-7994
IS - 1
M1 - 1
ER -