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MR-proADM Predicts Exercise Capacity and Survival Superior to Other Biomarkers in PH

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MR-proADM Predicts Exercise Capacity and Survival Superior to Other Biomarkers in PH. / Kolditz, Martin; Seyfarth, Hans-Jürgen; Wilkens, Heinrike; Ewert, Ralf; Bollmann, Tom; Dinter, Christiane; Hertel, Sabine; Klose, Hans; Opitz, Christian; Grünig, Ekkehard; Höffken, Gert; Halank, Michael.

in: LUNG, Jahrgang 193, Nr. 6, 12.2015, S. 901-10.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Kolditz, M, Seyfarth, H-J, Wilkens, H, Ewert, R, Bollmann, T, Dinter, C, Hertel, S, Klose, H, Opitz, C, Grünig, E, Höffken, G & Halank, M 2015, 'MR-proADM Predicts Exercise Capacity and Survival Superior to Other Biomarkers in PH', LUNG, Jg. 193, Nr. 6, S. 901-10. https://doi.org/10.1007/s00408-015-9802-y

APA

Kolditz, M., Seyfarth, H-J., Wilkens, H., Ewert, R., Bollmann, T., Dinter, C., Hertel, S., Klose, H., Opitz, C., Grünig, E., Höffken, G., & Halank, M. (2015). MR-proADM Predicts Exercise Capacity and Survival Superior to Other Biomarkers in PH. LUNG, 193(6), 901-10. https://doi.org/10.1007/s00408-015-9802-y

Vancouver

Kolditz M, Seyfarth H-J, Wilkens H, Ewert R, Bollmann T, Dinter C et al. MR-proADM Predicts Exercise Capacity and Survival Superior to Other Biomarkers in PH. LUNG. 2015 Dez;193(6):901-10. https://doi.org/10.1007/s00408-015-9802-y

Bibtex

@article{d4f2b617364749b9a77182b8ed3d47c7,
title = "MR-proADM Predicts Exercise Capacity and Survival Superior to Other Biomarkers in PH",
abstract = "PURPOSE: Besides the established biomarker NT-proBNP, the new cardiovascular biomarkers MR-proANP, MR-proADM, Copeptin, and CT-proET-1 are promising to evaluate hemodynamics, exercise parameters, and prognosis in patients with pulmonary hypertension (PH).METHODS: 125 consecutive patients with pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension (CTEPH) were prospectively enrolled at five German PH centers. Blood samples were taken during right heart catheterization. The primary study endpoint was the correlation between biomarkers and hemodynamic and exercise parameters. As secondary endpoint, prediction of 1-year mortality was evaluated.RESULTS: MR-proADM showed the strongest correlations with 6MWD and VO2peak, whereas NT-proBNP showed the strongest correlations with PVR, PAPm, and CI. In multivariate analysis, only MR-proADM was independently associated with exercise variables, whereas only NT-proBNP independently predicted hemodynamic parameters. All biomarkers were associated with 1-year survival, with MR-proADM showing the highest C index of 0.78. In multivariate analysis, MR-proADM predicted survival independent of age, 6-MWD, CI, RAP, and NT-proBNP. The cut-off of 1.08 nmol/l provided a sensitivity of 83 % and specificity of 66 %.CONCLUSIONS: Different biomarkers reflect distinctive disease aspects in PH. NT-proBNP best predicts hemodynamic impairment while MR-proADM strongly correlates with exercise capacity. Additionally, MR-proADM represents a promising new marker to evaluate prognosis in patients with PAH and CTEPH. Multi-marker strategies should further be evaluated.",
author = "Martin Kolditz and Hans-J{\"u}rgen Seyfarth and Heinrike Wilkens and Ralf Ewert and Tom Bollmann and Christiane Dinter and Sabine Hertel and Hans Klose and Christian Opitz and Ekkehard Gr{\"u}nig and Gert H{\"o}ffken and Michael Halank",
year = "2015",
month = dec,
doi = "10.1007/s00408-015-9802-y",
language = "English",
volume = "193",
pages = "901--10",
journal = "LUNG",
issn = "0341-2040",
publisher = "Springer New York",
number = "6",

}

RIS

TY - JOUR

T1 - MR-proADM Predicts Exercise Capacity and Survival Superior to Other Biomarkers in PH

AU - Kolditz, Martin

AU - Seyfarth, Hans-Jürgen

AU - Wilkens, Heinrike

AU - Ewert, Ralf

AU - Bollmann, Tom

AU - Dinter, Christiane

AU - Hertel, Sabine

AU - Klose, Hans

AU - Opitz, Christian

AU - Grünig, Ekkehard

AU - Höffken, Gert

AU - Halank, Michael

PY - 2015/12

Y1 - 2015/12

N2 - PURPOSE: Besides the established biomarker NT-proBNP, the new cardiovascular biomarkers MR-proANP, MR-proADM, Copeptin, and CT-proET-1 are promising to evaluate hemodynamics, exercise parameters, and prognosis in patients with pulmonary hypertension (PH).METHODS: 125 consecutive patients with pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension (CTEPH) were prospectively enrolled at five German PH centers. Blood samples were taken during right heart catheterization. The primary study endpoint was the correlation between biomarkers and hemodynamic and exercise parameters. As secondary endpoint, prediction of 1-year mortality was evaluated.RESULTS: MR-proADM showed the strongest correlations with 6MWD and VO2peak, whereas NT-proBNP showed the strongest correlations with PVR, PAPm, and CI. In multivariate analysis, only MR-proADM was independently associated with exercise variables, whereas only NT-proBNP independently predicted hemodynamic parameters. All biomarkers were associated with 1-year survival, with MR-proADM showing the highest C index of 0.78. In multivariate analysis, MR-proADM predicted survival independent of age, 6-MWD, CI, RAP, and NT-proBNP. The cut-off of 1.08 nmol/l provided a sensitivity of 83 % and specificity of 66 %.CONCLUSIONS: Different biomarkers reflect distinctive disease aspects in PH. NT-proBNP best predicts hemodynamic impairment while MR-proADM strongly correlates with exercise capacity. Additionally, MR-proADM represents a promising new marker to evaluate prognosis in patients with PAH and CTEPH. Multi-marker strategies should further be evaluated.

AB - PURPOSE: Besides the established biomarker NT-proBNP, the new cardiovascular biomarkers MR-proANP, MR-proADM, Copeptin, and CT-proET-1 are promising to evaluate hemodynamics, exercise parameters, and prognosis in patients with pulmonary hypertension (PH).METHODS: 125 consecutive patients with pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension (CTEPH) were prospectively enrolled at five German PH centers. Blood samples were taken during right heart catheterization. The primary study endpoint was the correlation between biomarkers and hemodynamic and exercise parameters. As secondary endpoint, prediction of 1-year mortality was evaluated.RESULTS: MR-proADM showed the strongest correlations with 6MWD and VO2peak, whereas NT-proBNP showed the strongest correlations with PVR, PAPm, and CI. In multivariate analysis, only MR-proADM was independently associated with exercise variables, whereas only NT-proBNP independently predicted hemodynamic parameters. All biomarkers were associated with 1-year survival, with MR-proADM showing the highest C index of 0.78. In multivariate analysis, MR-proADM predicted survival independent of age, 6-MWD, CI, RAP, and NT-proBNP. The cut-off of 1.08 nmol/l provided a sensitivity of 83 % and specificity of 66 %.CONCLUSIONS: Different biomarkers reflect distinctive disease aspects in PH. NT-proBNP best predicts hemodynamic impairment while MR-proADM strongly correlates with exercise capacity. Additionally, MR-proADM represents a promising new marker to evaluate prognosis in patients with PAH and CTEPH. Multi-marker strategies should further be evaluated.

U2 - 10.1007/s00408-015-9802-y

DO - 10.1007/s00408-015-9802-y

M3 - SCORING: Journal article

C2 - 26363916

VL - 193

SP - 901

EP - 910

JO - LUNG

JF - LUNG

SN - 0341-2040

IS - 6

ER -