MRI-based and CT-based thrombolytic therapy in acute stroke within and beyond established time windows: an analysis of 1210 patients.
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MRI-based and CT-based thrombolytic therapy in acute stroke within and beyond established time windows: an analysis of 1210 patients. / Schellinger, Peter D; Thomalla, Götz; Fiehler, Jens; Köhrmann, Martin; Molina, Carlos A; Neumann-Haefelin, Tobias; Ribo, Marc; Singer, Oliver C; Zaro-Weber, Olivier; Sobesky, Jan.
in: STROKE, Jahrgang 38, Nr. 10, 10, 2007, S. 2640-2645.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - MRI-based and CT-based thrombolytic therapy in acute stroke within and beyond established time windows: an analysis of 1210 patients.
AU - Schellinger, Peter D
AU - Thomalla, Götz
AU - Fiehler, Jens
AU - Köhrmann, Martin
AU - Molina, Carlos A
AU - Neumann-Haefelin, Tobias
AU - Ribo, Marc
AU - Singer, Oliver C
AU - Zaro-Weber, Olivier
AU - Sobesky, Jan
PY - 2007
Y1 - 2007
N2 - BACKGROUND AND PURPOSE: The use of intravenous thrombolysis is restricted to a minority of patients by the rigid 3-hour time window. This window may be extended by using modern imaging-based selection algorithms. We assessed safety and efficacy of MRI-based thrombolysis within and beyond 3 hours compared with standard CT-based thrombolysis. METHODS: Five European stroke centers pooled the core data of their CT- and MRI-based prospective thrombolysis databases. Safety outcomes were predefined as symptomatic intracranial hemorrhage and mortality. Primary efficacy outcome was a favorable outcome (modified Rankin Scale 0 to 1). We performed univariate and multivariate analyses for all end points, including age, National Institutes of Health Stroke Scale, treatment group (CT 3 hours), and onset to treatment time as variables. RESULTS: A total of 1210 patients were included (CT 3 hours: N=180). Median age, National Institutes of Health Stroke Scale, and onset to treatment time were 69, 67, and 68.5 years (P=0.66); 12, 13, and 14 points (P=0.019); and 130, 135, and 240 minutes (P
AB - BACKGROUND AND PURPOSE: The use of intravenous thrombolysis is restricted to a minority of patients by the rigid 3-hour time window. This window may be extended by using modern imaging-based selection algorithms. We assessed safety and efficacy of MRI-based thrombolysis within and beyond 3 hours compared with standard CT-based thrombolysis. METHODS: Five European stroke centers pooled the core data of their CT- and MRI-based prospective thrombolysis databases. Safety outcomes were predefined as symptomatic intracranial hemorrhage and mortality. Primary efficacy outcome was a favorable outcome (modified Rankin Scale 0 to 1). We performed univariate and multivariate analyses for all end points, including age, National Institutes of Health Stroke Scale, treatment group (CT 3 hours), and onset to treatment time as variables. RESULTS: A total of 1210 patients were included (CT 3 hours: N=180). Median age, National Institutes of Health Stroke Scale, and onset to treatment time were 69, 67, and 68.5 years (P=0.66); 12, 13, and 14 points (P=0.019); and 130, 135, and 240 minutes (P
M3 - SCORING: Zeitschriftenaufsatz
VL - 38
SP - 2640
EP - 2645
JO - STROKE
JF - STROKE
SN - 0039-2499
IS - 10
M1 - 10
ER -
