Motivational reserve: motivation-related occupational abilities and risk of mild cognitive impairment and Alzheimer disease.

Simon Forstmeier; Andreas Maercker; Wolfgang Maier; Hendrik Bussche van den; Steffi Riedel-Heller; Hanna Kaduszkiewicz; Michael Pentzek; Siegfried Weyerer; Horst Bickel; Franziska Tebarth; Melanie Luppa; Anja Wollny; Birgitt Wiese; Michael Wagner; AgeCoDe Study Group

Motivational reserve: motivation-related occupational abilities and risk of mild cognitive impairment and Alzheimer disease.

Standard

Motivational reserve: motivation-related occupational abilities and risk of mild cognitive impairment and Alzheimer disease. / Forstmeier, Simon; Maercker, Andreas; Maier, Wolfgang; Bussche van den, Hendrik; Riedel-Heller, Steffi; Kaduszkiewicz, Hanna; Pentzek, Michael; Weyerer, Siegfried; Bickel, Horst; Tebarth, Franziska; Luppa, Melanie; Wollny, Anja; Wiese, Birgitt; Wagner, Michael; Group, AgeCoDe Study.

in: PSYCHOL AGING, Jahrgang 27, Nr. 2, 2, 2012, S. 353-363.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Forstmeier, S, Maercker, A, Maier, W, Bussche van den, H, Riedel-Heller, S, Kaduszkiewicz, H, Pentzek, M, Weyerer, S, Bickel, H, Tebarth, F, Luppa, M, Wollny, A, Wiese, B, Wagner, M & Group, AS 2012, 'Motivational reserve: motivation-related occupational abilities and risk of mild cognitive impairment and Alzheimer disease.', PSYCHOL AGING, Jg. 27, Nr. 2, 2, S. 353-363. <http://www.ncbi.nlm.nih.gov/pubmed/21875213?dopt=Citation>

APA

Forstmeier, S., Maercker, A., Maier, W., Bussche van den, H., Riedel-Heller, S., Kaduszkiewicz, H., Pentzek, M., Weyerer, S., Bickel, H., Tebarth, F., Luppa, M., Wollny, A., Wiese, B., Wagner, M., & Group, A. S. (2012). Motivational reserve: motivation-related occupational abilities and risk of mild cognitive impairment and Alzheimer disease. PSYCHOL AGING, 27(2), 353-363. [2]. http://www.ncbi.nlm.nih.gov/pubmed/21875213?dopt=Citation

Vancouver

Forstmeier S, Maercker A, Maier W, Bussche van den H, Riedel-Heller S, Kaduszkiewicz H et al. Motivational reserve: motivation-related occupational abilities and risk of mild cognitive impairment and Alzheimer disease. PSYCHOL AGING. 2012;27(2):353-363. 2.

Bibtex

@article{5344afcad4bb4f69953098be6dc9c42d,

title = "Motivational reserve: motivation-related occupational abilities and risk of mild cognitive impairment and Alzheimer disease.",

abstract = "Midlife motivational abilities, that is, skills to initiate and persevere in the implementation of goals, have been related to mental and physical health, but their association with risk of mild cognitive impairment (MCI) and Alzheimer's disease (AD) has not yet been directly investigated. This relation was examined with data from the German Study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe). A total of 3,327 nondemented participants (50.3% of a randomly selected sample) aged 75-89 years were recruited in primary care and followed up twice (after 1.5 and 3 years). Motivation-related occupational abilities were estimated on the basis of the main occupation (assessed at follow-up II) using the Occupational Information Network (O* NET) database, which provides detailed information on worker characteristics and abilities. Cox proportional hazards models were used to evaluate the relative risk of developing MCI and AD in relation to motivation-related occupational abilities, adjusting for various covariates. Over the 3 years of follow-up, 15.2% participants developed MCI and 3.0% developed AD. In a fully adjusted model, motivation-related occupational abilities were found to be associated with a reduced risk of MCI (HR: 0.77; 95% CI: 0.64-0.92). Motivation-related occupational abilities were associated with reduced risk of AD in ApoE ?4 carriers (HR: 0.48; CI: 0.25-0.91), but not in noncarriers (HR: 0.99; CI: 0.65-1.53). These results suggest that midlife motivational abilities are associated with reduced risk of MCI in general and with reduced risk of AD in ApoE ?4 carriers. Revealing the mechanisms underlying this association may inform novel prevention strategies for decelerating cognitive decline in old age.",

keywords = "Humans, Male, Aged, Female, Aged, 80 and over, Risk Factors, Neuropsychological Tests, Follow-Up Studies, Proportional Hazards Models, Confidence Intervals, Incidence, Genetic Predisposition to Disease, Heterozygote, Interview, Psychological, Germany/epidemiology, Motivation/*physiology, Aging/*psychology, Self Efficacy, Alzheimer Disease/*epidemiology/genetics/psychology, Apolipoprotein E4, Cognitive Reserve/*physiology, Goals, Mild Cognitive Impairment/*epidemiology/psychology, *Occupations, Professional Competence, Humans, Male, Aged, Female, Aged, 80 and over, Risk Factors, Neuropsychological Tests, Follow-Up Studies, Proportional Hazards Models, Confidence Intervals, Incidence, Genetic Predisposition to Disease, Heterozygote, Interview, Psychological, Germany/epidemiology, Motivation/*physiology, Aging/*psychology, Self Efficacy, Alzheimer Disease/*epidemiology/genetics/psychology, Apolipoprotein E4, Cognitive Reserve/*physiology, Goals, Mild Cognitive Impairment/*epidemiology/psychology, *Occupations, Professional Competence",

author = "Simon Forstmeier and Andreas Maercker and Wolfgang Maier and {Bussche van den}, Hendrik and Steffi Riedel-Heller and Hanna Kaduszkiewicz and Michael Pentzek and Siegfried Weyerer and Horst Bickel and Franziska Tebarth and Melanie Luppa and Anja Wollny and Birgitt Wiese and Michael Wagner and Group, {AgeCoDe Study}",

year = "2012",

language = "English",

volume = "27",

pages = "353--363",

journal = "PSYCHOL AGING",

issn = "0882-7974",

publisher = "American Psychological Association Inc.",

number = "2",

}

RIS

TY - JOUR

T1 - Motivational reserve: motivation-related occupational abilities and risk of mild cognitive impairment and Alzheimer disease.

AU - Forstmeier, Simon

AU - Maercker, Andreas

AU - Maier, Wolfgang

AU - Bussche van den, Hendrik

AU - Riedel-Heller, Steffi

AU - Kaduszkiewicz, Hanna

AU - Pentzek, Michael

AU - Weyerer, Siegfried

AU - Bickel, Horst

AU - Tebarth, Franziska

AU - Luppa, Melanie

AU - Wollny, Anja

AU - Wiese, Birgitt

AU - Wagner, Michael

AU - Group, AgeCoDe Study

PY - 2012

Y1 - 2012

N2 - Midlife motivational abilities, that is, skills to initiate and persevere in the implementation of goals, have been related to mental and physical health, but their association with risk of mild cognitive impairment (MCI) and Alzheimer's disease (AD) has not yet been directly investigated. This relation was examined with data from the German Study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe). A total of 3,327 nondemented participants (50.3% of a randomly selected sample) aged 75-89 years were recruited in primary care and followed up twice (after 1.5 and 3 years). Motivation-related occupational abilities were estimated on the basis of the main occupation (assessed at follow-up II) using the Occupational Information Network (O* NET) database, which provides detailed information on worker characteristics and abilities. Cox proportional hazards models were used to evaluate the relative risk of developing MCI and AD in relation to motivation-related occupational abilities, adjusting for various covariates. Over the 3 years of follow-up, 15.2% participants developed MCI and 3.0% developed AD. In a fully adjusted model, motivation-related occupational abilities were found to be associated with a reduced risk of MCI (HR: 0.77; 95% CI: 0.64-0.92). Motivation-related occupational abilities were associated with reduced risk of AD in ApoE ?4 carriers (HR: 0.48; CI: 0.25-0.91), but not in noncarriers (HR: 0.99; CI: 0.65-1.53). These results suggest that midlife motivational abilities are associated with reduced risk of MCI in general and with reduced risk of AD in ApoE ?4 carriers. Revealing the mechanisms underlying this association may inform novel prevention strategies for decelerating cognitive decline in old age.

AB - Midlife motivational abilities, that is, skills to initiate and persevere in the implementation of goals, have been related to mental and physical health, but their association with risk of mild cognitive impairment (MCI) and Alzheimer's disease (AD) has not yet been directly investigated. This relation was examined with data from the German Study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe). A total of 3,327 nondemented participants (50.3% of a randomly selected sample) aged 75-89 years were recruited in primary care and followed up twice (after 1.5 and 3 years). Motivation-related occupational abilities were estimated on the basis of the main occupation (assessed at follow-up II) using the Occupational Information Network (O* NET) database, which provides detailed information on worker characteristics and abilities. Cox proportional hazards models were used to evaluate the relative risk of developing MCI and AD in relation to motivation-related occupational abilities, adjusting for various covariates. Over the 3 years of follow-up, 15.2% participants developed MCI and 3.0% developed AD. In a fully adjusted model, motivation-related occupational abilities were found to be associated with a reduced risk of MCI (HR: 0.77; 95% CI: 0.64-0.92). Motivation-related occupational abilities were associated with reduced risk of AD in ApoE ?4 carriers (HR: 0.48; CI: 0.25-0.91), but not in noncarriers (HR: 0.99; CI: 0.65-1.53). These results suggest that midlife motivational abilities are associated with reduced risk of MCI in general and with reduced risk of AD in ApoE ?4 carriers. Revealing the mechanisms underlying this association may inform novel prevention strategies for decelerating cognitive decline in old age.

KW - Humans

KW - Male

KW - Aged

KW - Female

KW - Aged, 80 and over

KW - Risk Factors

KW - Neuropsychological Tests

KW - Follow-Up Studies

KW - Proportional Hazards Models

KW - Confidence Intervals

KW - Incidence

KW - Genetic Predisposition to Disease

KW - Heterozygote

KW - Interview, Psychological

KW - Germany/epidemiology

KW - Motivation/physiology

KW - Aging/psychology

KW - Self Efficacy

KW - Alzheimer Disease/epidemiology/genetics/psychology

KW - Apolipoprotein E4

KW - Cognitive Reserve/physiology

KW - Goals

KW - Mild Cognitive Impairment/epidemiology/psychology

KW - Occupations

KW - Professional Competence