Morphology of Ruptured and Unruptured Intracranial Aneurysms

Tammam Abboud; Jihad Rustom; Maxim Bester; Patrick Czorlich; Eik Vettorazzi; Hans O Pinnschmidt; Manfred Westphal; Jan Regelsberger

doi:10.1016/j.wneu.2016.12.053

Morphology of Ruptured and Unruptured Intracranial Aneurysms

Standard

Morphology of Ruptured and Unruptured Intracranial Aneurysms. / Abboud, Tammam; Rustom, Jihad; Bester, Maxim; Czorlich, Patrick; Vettorazzi, Eik ; Pinnschmidt, Hans O; Westphal, Manfred; Regelsberger, Jan.

in: WORLD NEUROSURG, Jahrgang 99, 03.2017, S. 610-617.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Abboud, T, Rustom, J, Bester, M, Czorlich, P, Vettorazzi, E , Pinnschmidt, HO, Westphal, M & Regelsberger, J 2017, 'Morphology of Ruptured and Unruptured Intracranial Aneurysms', WORLD NEUROSURG, Jg. 99, S. 610-617. https://doi.org/10.1016/j.wneu.2016.12.053

APA

Abboud, T., Rustom, J., Bester, M., Czorlich, P., Vettorazzi, E., Pinnschmidt, H. O., Westphal, M., & Regelsberger, J. (2017). Morphology of Ruptured and Unruptured Intracranial Aneurysms. WORLD NEUROSURG, 99, 610-617. https://doi.org/10.1016/j.wneu.2016.12.053

Vancouver

Abboud T, Rustom J, Bester M, Czorlich P, Vettorazzi E , Pinnschmidt HO et al. Morphology of Ruptured and Unruptured Intracranial Aneurysms. WORLD NEUROSURG. 2017 Mär;99:610-617. https://doi.org/10.1016/j.wneu.2016.12.053

Bibtex

@article{5c4e902857964738813870472bfcaf84,

title = "Morphology of Ruptured and Unruptured Intracranial Aneurysms",

abstract = "BACKGROUND: In addition to size and location, morphology of intracranial aneurysm has been proposed to predict rupture. This study was undertaken to compare morphological features between ruptured and unruptured aneurysms and identify those associated with higher rupture risk.METHODS: Between 2010 and 2014, 301 patients with SAH and 204 with unruptuted aneurysms were admitted to our hospital. Two investigators reviewed 3-dimensional angiograms of all aneurysms. Risk factors for rupture were identified. Morphology was classified into single sac aneurysms with smooth margin, single sac with irregular margin, aneurysms with daughter sac and multilobulated aneurysms. The value of morphology in predicting rupture was tested using logistic regression.RESULTS: 420 aneurysms met the inclusion criteria. Multilobulated aneurysm was the most frequent finding among ruptured aneurysms followed by single sac with irregular margin, aneurysm with daughter sac and single sac with smooth margin, 44.9%, 25.9%, 18% and 11.2%, respectively. Among unruptured aneurysms, single sac with smooth margin was the most frequent finding, followed by single sac with irregular margin, multilobulated aneurysm and aneurysm with daughter sac, 38.1%, 29.8%, 20.9% and 11.2%, respectively. Morphology was an independent predictor of rupture, (ROC-AUC 0.693, p<0.001). Risk of rupture increased by factor of 3 (5-95% CI 1.6-5.3) from single sac with regular margin to irregular margin, by factor of 5.5 (5-95% CI 2.8-11.0) to daughter sac and by factor of 7.2 (5-95% CI 4.1-13.1) to multilobulated aneurysm.CONCLUSIONS: Morphology might have an independent predictive value of aneurysm rupture. Risk of rupture might increase according to extent of morphological change. Prospective studies will be necessary to evaluate the influence of aneurysm morphology on natural history.",

author = "Tammam Abboud and Jihad Rustom and Maxim Bester and Patrick Czorlich and Eik Vettorazzi and Pinnschmidt, {Hans O} and Manfred Westphal and Jan Regelsberger",

year = "2017",

month = mar,

doi = "10.1016/j.wneu.2016.12.053",

language = "English",

volume = "99",

pages = "610--617",

journal = "WORLD NEUROSURG",

issn = "1878-8750",

publisher = "Elsevier Inc.",

}

RIS

TY - JOUR

T1 - Morphology of Ruptured and Unruptured Intracranial Aneurysms

AU - Abboud, Tammam

AU - Rustom, Jihad

AU - Bester, Maxim

AU - Czorlich, Patrick

AU - Vettorazzi, Eik

AU - Pinnschmidt, Hans O

AU - Westphal, Manfred

AU - Regelsberger, Jan

PY - 2017/3

Y1 - 2017/3

N2 - BACKGROUND: In addition to size and location, morphology of intracranial aneurysm has been proposed to predict rupture. This study was undertaken to compare morphological features between ruptured and unruptured aneurysms and identify those associated with higher rupture risk.METHODS: Between 2010 and 2014, 301 patients with SAH and 204 with unruptuted aneurysms were admitted to our hospital. Two investigators reviewed 3-dimensional angiograms of all aneurysms. Risk factors for rupture were identified. Morphology was classified into single sac aneurysms with smooth margin, single sac with irregular margin, aneurysms with daughter sac and multilobulated aneurysms. The value of morphology in predicting rupture was tested using logistic regression.RESULTS: 420 aneurysms met the inclusion criteria. Multilobulated aneurysm was the most frequent finding among ruptured aneurysms followed by single sac with irregular margin, aneurysm with daughter sac and single sac with smooth margin, 44.9%, 25.9%, 18% and 11.2%, respectively. Among unruptured aneurysms, single sac with smooth margin was the most frequent finding, followed by single sac with irregular margin, multilobulated aneurysm and aneurysm with daughter sac, 38.1%, 29.8%, 20.9% and 11.2%, respectively. Morphology was an independent predictor of rupture, (ROC-AUC 0.693, p<0.001). Risk of rupture increased by factor of 3 (5-95% CI 1.6-5.3) from single sac with regular margin to irregular margin, by factor of 5.5 (5-95% CI 2.8-11.0) to daughter sac and by factor of 7.2 (5-95% CI 4.1-13.1) to multilobulated aneurysm.CONCLUSIONS: Morphology might have an independent predictive value of aneurysm rupture. Risk of rupture might increase according to extent of morphological change. Prospective studies will be necessary to evaluate the influence of aneurysm morphology on natural history.

AB - BACKGROUND: In addition to size and location, morphology of intracranial aneurysm has been proposed to predict rupture. This study was undertaken to compare morphological features between ruptured and unruptured aneurysms and identify those associated with higher rupture risk.METHODS: Between 2010 and 2014, 301 patients with SAH and 204 with unruptuted aneurysms were admitted to our hospital. Two investigators reviewed 3-dimensional angiograms of all aneurysms. Risk factors for rupture were identified. Morphology was classified into single sac aneurysms with smooth margin, single sac with irregular margin, aneurysms with daughter sac and multilobulated aneurysms. The value of morphology in predicting rupture was tested using logistic regression.RESULTS: 420 aneurysms met the inclusion criteria. Multilobulated aneurysm was the most frequent finding among ruptured aneurysms followed by single sac with irregular margin, aneurysm with daughter sac and single sac with smooth margin, 44.9%, 25.9%, 18% and 11.2%, respectively. Among unruptured aneurysms, single sac with smooth margin was the most frequent finding, followed by single sac with irregular margin, multilobulated aneurysm and aneurysm with daughter sac, 38.1%, 29.8%, 20.9% and 11.2%, respectively. Morphology was an independent predictor of rupture, (ROC-AUC 0.693, p<0.001). Risk of rupture increased by factor of 3 (5-95% CI 1.6-5.3) from single sac with regular margin to irregular margin, by factor of 5.5 (5-95% CI 2.8-11.0) to daughter sac and by factor of 7.2 (5-95% CI 4.1-13.1) to multilobulated aneurysm.CONCLUSIONS: Morphology might have an independent predictive value of aneurysm rupture. Risk of rupture might increase according to extent of morphological change. Prospective studies will be necessary to evaluate the influence of aneurysm morphology on natural history.

U2 - 10.1016/j.wneu.2016.12.053

DO - 10.1016/j.wneu.2016.12.053

M3 - SCORING: Journal article

C2 - 28017741

VL - 99

SP - 610

EP - 617

JO - WORLD NEUROSURG

JF - WORLD NEUROSURG

SN - 1878-8750

ER -