Morphology of perineuronal nets in tenascin-R and parvalbumin single and double knockout mice
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Morphology of perineuronal nets in tenascin-R and parvalbumin single and double knockout mice. / Haunsø, A; Ibrahim, M; Bartsch, U; Letiembre, M; Celio, M R; Menoud, P.
in: BRAIN RES, Jahrgang 864, Nr. 1, 02.05.2000, S. 142-5.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Morphology of perineuronal nets in tenascin-R and parvalbumin single and double knockout mice
AU - Haunsø, A
AU - Ibrahim, M
AU - Bartsch, U
AU - Letiembre, M
AU - Celio, M R
AU - Menoud, P
PY - 2000/5/2
Y1 - 2000/5/2
N2 - Recently identified chondroitin sulphate proteoglycans in perineuronal nets include neurocan and phosphacan. However, the function and assembly of these components has yet to be resolved. In this study we show morphological alteration in Wisteria floribunda labelled nets around cortical interneurones both in tenascin-R knockout and tenascin-R/parvalbumin double knockout mice. This alteration reflects the loss of phosphacan and neurocan from cortical nets in mice deficient in tenascin-R. No effect on the membrane related cytoskeleton, as revealed by ankyrin(R), was observed in any of the mice. These results on mice lacking tenascin-R substantiate previously reported in vitro interactions between tenascin-R and phosphacan and neurocan.
AB - Recently identified chondroitin sulphate proteoglycans in perineuronal nets include neurocan and phosphacan. However, the function and assembly of these components has yet to be resolved. In this study we show morphological alteration in Wisteria floribunda labelled nets around cortical interneurones both in tenascin-R knockout and tenascin-R/parvalbumin double knockout mice. This alteration reflects the loss of phosphacan and neurocan from cortical nets in mice deficient in tenascin-R. No effect on the membrane related cytoskeleton, as revealed by ankyrin(R), was observed in any of the mice. These results on mice lacking tenascin-R substantiate previously reported in vitro interactions between tenascin-R and phosphacan and neurocan.
KW - Animals
KW - Cell Size
KW - Cerebral Cortex
KW - Chondroitin Sulfate Proteoglycans
KW - Extracellular Matrix
KW - Fluorescent Antibody Technique
KW - Lectins, C-Type
KW - Mice
KW - Mice, Knockout
KW - Nerve Tissue Proteins
KW - Neurons
KW - Parvalbumins
KW - Receptor-Like Protein Tyrosine Phosphatases, Class 5
KW - Tenascin
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
M3 - SCORING: Journal article
C2 - 10793198
VL - 864
SP - 142
EP - 145
JO - BRAIN RES
JF - BRAIN RES
SN - 0006-8993
IS - 1
ER -