More than just noise: Inter-individual differences in fear acquisition, extinction and return of fear in humans - Biological, experiential, temperamental factors, and methodological pitfalls

Tina B Lonsdorf; Christian J Merz

doi:10.1016/j.neubiorev.2017.07.007

More than just noise

Standard

More than just noise : Inter-individual differences in fear acquisition, extinction and return of fear in humans - Biological, experiential, temperamental factors, and methodological pitfalls. / Lonsdorf, Tina B; Merz, Christian J.

in: NEUROSCI BIOBEHAV R, Jahrgang 80, 09.2017, S. 703-728.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Lonsdorf, TB & Merz, CJ 2017, 'More than just noise: Inter-individual differences in fear acquisition, extinction and return of fear in humans - Biological, experiential, temperamental factors, and methodological pitfalls', NEUROSCI BIOBEHAV R, Jg. 80, S. 703-728. https://doi.org/10.1016/j.neubiorev.2017.07.007

APA

Lonsdorf, T. B., & Merz, C. J. (2017). More than just noise: Inter-individual differences in fear acquisition, extinction and return of fear in humans - Biological, experiential, temperamental factors, and methodological pitfalls. NEUROSCI BIOBEHAV R, 80, 703-728. https://doi.org/10.1016/j.neubiorev.2017.07.007

Vancouver

Lonsdorf TB, Merz CJ. More than just noise: Inter-individual differences in fear acquisition, extinction and return of fear in humans - Biological, experiential, temperamental factors, and methodological pitfalls. NEUROSCI BIOBEHAV R. 2017 Sep;80:703-728. https://doi.org/10.1016/j.neubiorev.2017.07.007

Bibtex

@article{f9742ea4cde24c239da3c51fb247f011,

title = "More than just noise: Inter-individual differences in fear acquisition, extinction and return of fear in humans - Biological, experiential, temperamental factors, and methodological pitfalls",

abstract = "Why do only some individuals develop pathological anxiety following adverse events? Fear acquisition, extinction and return of fear paradigms serve as experimental learning models for the development, treatment and relapse of anxiety. Individual differences in experimental performance were however mostly regarded as 'noise' by researchers interested in basic associative learning principles. Our work for the first time presents a comprehensive literature overview and methodological discussion on inter-individual differences in fear acquisition, extinction and return of fear. We tell a story from noise that steadily develops into a meaningful tune and converges to a model of mechanisms contributing to individual risk/resilience with respect to fear and anxiety-related behavior. Furthermore, in light of the present 'replicability crisis' we identify methodological pitfalls and provide suggestions for study design and analyses tailored to individual difference research in fear conditioning. Ultimately, synergistic transdisciplinary and collaborative efforts hold promise to not only improve our mechanistic understanding but can also be expected to contribute to the development of specifically tailored ('individualized') intervention and targeted prevention programs in the future.",

keywords = "Journal Article, Review",

author = "Lonsdorf, {Tina B} and Merz, {Christian J}",

year = "2017",

month = sep,

doi = "10.1016/j.neubiorev.2017.07.007",

language = "English",

volume = "80",

pages = "703--728",

journal = "NEUROSCI BIOBEHAV R",

issn = "0149-7634",

publisher = "Elsevier Limited",

}

RIS

TY - JOUR

T1 - More than just noise

T2 - Inter-individual differences in fear acquisition, extinction and return of fear in humans - Biological, experiential, temperamental factors, and methodological pitfalls

AU - Lonsdorf, Tina B

AU - Merz, Christian J

PY - 2017/9

Y1 - 2017/9

N2 - Why do only some individuals develop pathological anxiety following adverse events? Fear acquisition, extinction and return of fear paradigms serve as experimental learning models for the development, treatment and relapse of anxiety. Individual differences in experimental performance were however mostly regarded as 'noise' by researchers interested in basic associative learning principles. Our work for the first time presents a comprehensive literature overview and methodological discussion on inter-individual differences in fear acquisition, extinction and return of fear. We tell a story from noise that steadily develops into a meaningful tune and converges to a model of mechanisms contributing to individual risk/resilience with respect to fear and anxiety-related behavior. Furthermore, in light of the present 'replicability crisis' we identify methodological pitfalls and provide suggestions for study design and analyses tailored to individual difference research in fear conditioning. Ultimately, synergistic transdisciplinary and collaborative efforts hold promise to not only improve our mechanistic understanding but can also be expected to contribute to the development of specifically tailored ('individualized') intervention and targeted prevention programs in the future.

AB - Why do only some individuals develop pathological anxiety following adverse events? Fear acquisition, extinction and return of fear paradigms serve as experimental learning models for the development, treatment and relapse of anxiety. Individual differences in experimental performance were however mostly regarded as 'noise' by researchers interested in basic associative learning principles. Our work for the first time presents a comprehensive literature overview and methodological discussion on inter-individual differences in fear acquisition, extinction and return of fear. We tell a story from noise that steadily develops into a meaningful tune and converges to a model of mechanisms contributing to individual risk/resilience with respect to fear and anxiety-related behavior. Furthermore, in light of the present 'replicability crisis' we identify methodological pitfalls and provide suggestions for study design and analyses tailored to individual difference research in fear conditioning. Ultimately, synergistic transdisciplinary and collaborative efforts hold promise to not only improve our mechanistic understanding but can also be expected to contribute to the development of specifically tailored ('individualized') intervention and targeted prevention programs in the future.

KW - Journal Article

KW - Review

U2 - 10.1016/j.neubiorev.2017.07.007

DO - 10.1016/j.neubiorev.2017.07.007

M3 - SCORING: Review article

C2 - 28764976

VL - 80

SP - 703

EP - 728

JO - NEUROSCI BIOBEHAV R

JF - NEUROSCI BIOBEHAV R

SN - 0149-7634

ER -