Monanchoxymycalin C with anticancer properties, new analogue of crambescidin 800 from the marine sponge Monanchora pulchra

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Monanchoxymycalin C with anticancer properties, new analogue of crambescidin 800 from the marine sponge Monanchora pulchra. / Shubina, Larisa Kimovna; Makarieva, Tatyana Nikolaevna; von Amsberg, Gunhild; Denisenko, Vladimir Anatolievich; Popov, Roman Sergeevich; Dyshlovoy, Sergey Anatolievich.

in: NAT PROD RES, 22.12.2017, S. 1-8.

Publikationen: SCORING: Beitrag in Fachzeitschrift/ZeitungSCORING: ZeitschriftenaufsatzForschungBegutachtung

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@article{8a98969ee92744cfbee041c109e9b805,
title = "Monanchoxymycalin C with anticancer properties, new analogue of crambescidin 800 from the marine sponge Monanchora pulchra",
abstract = "A new pentacyclic guanidine alkaloid, monanchoxymycalin C (1) was isolated from a new collection of marine sponge Monanchora pulchra along with the known monanchoxymycalin A (2). The structure of 1 was elucidated on the basis of spectroscopic data. Monanchoxymycalin C exhibits cytotoxic activity against human cancer HeLa cells at low micromolar concentrations, induces apoptosis-related death of malignant cells and inhibits cancer cell colony formation. In addition, synergistic and additive effects have been observed in combination with cisplatin.",
keywords = "Journal Article",
author = "Shubina, {Larisa Kimovna} and Makarieva, {Tatyana Nikolaevna} and {von Amsberg}, Gunhild and Denisenko, {Vladimir Anatolievich} and Popov, {Roman Sergeevich} and Dyshlovoy, {Sergey Anatolievich}",
year = "2017",
month = dec,
day = "22",
doi = "10.1080/14786419.2017.1419231",
language = "English",
pages = "1--8",
journal = "NAT PROD RES",
issn = "1478-6419",
publisher = "Taylor and Francis Ltd.",

}

RIS

TY - JOUR

T1 - Monanchoxymycalin C with anticancer properties, new analogue of crambescidin 800 from the marine sponge Monanchora pulchra

AU - Shubina, Larisa Kimovna

AU - Makarieva, Tatyana Nikolaevna

AU - von Amsberg, Gunhild

AU - Denisenko, Vladimir Anatolievich

AU - Popov, Roman Sergeevich

AU - Dyshlovoy, Sergey Anatolievich

PY - 2017/12/22

Y1 - 2017/12/22

N2 - A new pentacyclic guanidine alkaloid, monanchoxymycalin C (1) was isolated from a new collection of marine sponge Monanchora pulchra along with the known monanchoxymycalin A (2). The structure of 1 was elucidated on the basis of spectroscopic data. Monanchoxymycalin C exhibits cytotoxic activity against human cancer HeLa cells at low micromolar concentrations, induces apoptosis-related death of malignant cells and inhibits cancer cell colony formation. In addition, synergistic and additive effects have been observed in combination with cisplatin.

AB - A new pentacyclic guanidine alkaloid, monanchoxymycalin C (1) was isolated from a new collection of marine sponge Monanchora pulchra along with the known monanchoxymycalin A (2). The structure of 1 was elucidated on the basis of spectroscopic data. Monanchoxymycalin C exhibits cytotoxic activity against human cancer HeLa cells at low micromolar concentrations, induces apoptosis-related death of malignant cells and inhibits cancer cell colony formation. In addition, synergistic and additive effects have been observed in combination with cisplatin.

KW - Journal Article

U2 - 10.1080/14786419.2017.1419231

DO - 10.1080/14786419.2017.1419231

M3 - SCORING: Journal article

C2 - 29272957

SP - 1

EP - 8

JO - NAT PROD RES

JF - NAT PROD RES

SN - 1478-6419

ER -