Monanchoxymycalin C with anticancer properties, new analogue of crambescidin 800 from the marine sponge Monanchora pulchra
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Monanchoxymycalin C with anticancer properties, new analogue of crambescidin 800 from the marine sponge Monanchora pulchra. / Shubina, Larisa Kimovna; Makarieva, Tatyana Nikolaevna; von Amsberg, Gunhild; Denisenko, Vladimir Anatolievich; Popov, Roman Sergeevich; Dyshlovoy, Sergey Anatolievich.
in: NAT PROD RES, 22.12.2017, S. 1-8.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Monanchoxymycalin C with anticancer properties, new analogue of crambescidin 800 from the marine sponge Monanchora pulchra
AU - Shubina, Larisa Kimovna
AU - Makarieva, Tatyana Nikolaevna
AU - von Amsberg, Gunhild
AU - Denisenko, Vladimir Anatolievich
AU - Popov, Roman Sergeevich
AU - Dyshlovoy, Sergey Anatolievich
PY - 2017/12/22
Y1 - 2017/12/22
N2 - A new pentacyclic guanidine alkaloid, monanchoxymycalin C (1) was isolated from a new collection of marine sponge Monanchora pulchra along with the known monanchoxymycalin A (2). The structure of 1 was elucidated on the basis of spectroscopic data. Monanchoxymycalin C exhibits cytotoxic activity against human cancer HeLa cells at low micromolar concentrations, induces apoptosis-related death of malignant cells and inhibits cancer cell colony formation. In addition, synergistic and additive effects have been observed in combination with cisplatin.
AB - A new pentacyclic guanidine alkaloid, monanchoxymycalin C (1) was isolated from a new collection of marine sponge Monanchora pulchra along with the known monanchoxymycalin A (2). The structure of 1 was elucidated on the basis of spectroscopic data. Monanchoxymycalin C exhibits cytotoxic activity against human cancer HeLa cells at low micromolar concentrations, induces apoptosis-related death of malignant cells and inhibits cancer cell colony formation. In addition, synergistic and additive effects have been observed in combination with cisplatin.
KW - Journal Article
U2 - 10.1080/14786419.2017.1419231
DO - 10.1080/14786419.2017.1419231
M3 - SCORING: Journal article
C2 - 29272957
SP - 1
EP - 8
JO - NAT PROD RES
JF - NAT PROD RES
SN - 1478-6419
ER -