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Molecular profiling of liver cancer heterogeneity

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Molecular profiling of liver cancer heterogeneity. / Craig, Amanda J; von Felden, Johann; Villanueva, Augusto.

in: DISCOV MED, Jahrgang 24, Nr. 131, 09.2017, S. 117-125.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Craig, AJ, von Felden, J & Villanueva, A 2017, 'Molecular profiling of liver cancer heterogeneity', DISCOV MED, Jg. 24, Nr. 131, S. 117-125.

APA

Craig, A. J., von Felden, J., & Villanueva, A. (2017). Molecular profiling of liver cancer heterogeneity. DISCOV MED, 24(131), 117-125.

Vancouver

Craig AJ, von Felden J, Villanueva A. Molecular profiling of liver cancer heterogeneity. DISCOV MED. 2017 Sep;24(131):117-125.

Bibtex

@article{8efe6014eeb64d7cb49a237213bbcdaf,
title = "Molecular profiling of liver cancer heterogeneity",
abstract = "Liver cancer has the highest increase in incidence and mortality of all cancers in the United States in recent decades. A major effort has been taken over the last 10 years to understand molecular heterogeneity between tumors of different patients through the development of mutation signatures and molecular classifications. More recently, attention has shifted to understanding intra-tumor heterogeneity (ITH). Several possibilities exist as to the underlying mechanisms that drive ITH in liver cancer, including cancer stem cells (CSCs) and neutral and clonal evolution. Tracking ITH changes in patients over treatment courses will become imperative as precision medicine comes to the forefront of cancer management. Here we review the models of ITH development in liver cancer and the impact ITH assessment can have on clinical management.",
keywords = "Journal Article",
author = "Craig, {Amanda J} and {von Felden}, Johann and Augusto Villanueva",
note = "xxx",
year = "2017",
month = sep,
language = "English",
volume = "24",
pages = "117--125",
journal = "DISCOV MED",
issn = "1539-6509",
publisher = "Discovery Medicine",
number = "131",

}

RIS

TY - JOUR

T1 - Molecular profiling of liver cancer heterogeneity

AU - Craig, Amanda J

AU - von Felden, Johann

AU - Villanueva, Augusto

N1 - xxx

PY - 2017/9

Y1 - 2017/9

N2 - Liver cancer has the highest increase in incidence and mortality of all cancers in the United States in recent decades. A major effort has been taken over the last 10 years to understand molecular heterogeneity between tumors of different patients through the development of mutation signatures and molecular classifications. More recently, attention has shifted to understanding intra-tumor heterogeneity (ITH). Several possibilities exist as to the underlying mechanisms that drive ITH in liver cancer, including cancer stem cells (CSCs) and neutral and clonal evolution. Tracking ITH changes in patients over treatment courses will become imperative as precision medicine comes to the forefront of cancer management. Here we review the models of ITH development in liver cancer and the impact ITH assessment can have on clinical management.

AB - Liver cancer has the highest increase in incidence and mortality of all cancers in the United States in recent decades. A major effort has been taken over the last 10 years to understand molecular heterogeneity between tumors of different patients through the development of mutation signatures and molecular classifications. More recently, attention has shifted to understanding intra-tumor heterogeneity (ITH). Several possibilities exist as to the underlying mechanisms that drive ITH in liver cancer, including cancer stem cells (CSCs) and neutral and clonal evolution. Tracking ITH changes in patients over treatment courses will become imperative as precision medicine comes to the forefront of cancer management. Here we review the models of ITH development in liver cancer and the impact ITH assessment can have on clinical management.

KW - Journal Article

M3 - SCORING: Journal article

C2 - 28972880

VL - 24

SP - 117

EP - 125

JO - DISCOV MED

JF - DISCOV MED

SN - 1539-6509

IS - 131

ER -