[Molecular markers in salivary gland tumors: their use in diagnostic and prognostic workup]
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[Molecular markers in salivary gland tumors: their use in diagnostic and prognostic workup]. / Fehr, A; Stenman, G; Bullerdiek, J; Löning, Thomas.
in: PATHOLOGE, Jahrgang 30, Nr. 6, 6, 2009, S. 466-471.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - [Molecular markers in salivary gland tumors: their use in diagnostic and prognostic workup]
AU - Fehr, A
AU - Stenman, G
AU - Bullerdiek, J
AU - Löning, Thomas
PY - 2009
Y1 - 2009
N2 - The molecular genetic background of salivary gland neoplasms has not been characterized in detail to date. However, interesting target genes which could be used as prognostic and diagnostic molecular biomarkers have already been identified, e.g. CRTC1-MAML2 in mucoepidermoid carcinoma, or PLAG1 and HMGA2 in pleomorphic adenoma. In particular, CRTC1-MAML2 has shown strong diagnostic and prognostic potential in recent years. One of the major advantages of molecular tumor markers is that valid results are obtained on minute cell and/or tissue samples. Due to high-throughput techniques like comparative genome hybridization (CGH), micro- or gene profiling array detection of new marker genes can be expected in the future. This is also true for the most frequent malignant salivary gland tumors after the mucoepidermoid carcinoma, i.e. adenoid cystic carcinomas and acinic cell carcinomas.
AB - The molecular genetic background of salivary gland neoplasms has not been characterized in detail to date. However, interesting target genes which could be used as prognostic and diagnostic molecular biomarkers have already been identified, e.g. CRTC1-MAML2 in mucoepidermoid carcinoma, or PLAG1 and HMGA2 in pleomorphic adenoma. In particular, CRTC1-MAML2 has shown strong diagnostic and prognostic potential in recent years. One of the major advantages of molecular tumor markers is that valid results are obtained on minute cell and/or tissue samples. Due to high-throughput techniques like comparative genome hybridization (CGH), micro- or gene profiling array detection of new marker genes can be expected in the future. This is also true for the most frequent malignant salivary gland tumors after the mucoepidermoid carcinoma, i.e. adenoid cystic carcinomas and acinic cell carcinomas.
KW - Humans
KW - Prognosis
KW - DNA Mutational Analysis
KW - Neoplasm Proteins genetics
KW - Adenoma, Pleomorphic diagnosis
KW - Carcinoma, Acinar Cell
KW - Carcinoma, Adenoid Cystic
KW - Carcinoma, Mucoepidermoid diagnosis
KW - Chromosome Aberrations
KW - Comparative Genomic Hybridization
KW - DNA-Binding Proteins
KW - Gene Fusion
KW - HMGA2 Protein
KW - Nuclear Proteins
KW - Protein Array Analysis
KW - Salivary Gland Neoplasms diagnosis
KW - Salivary Glands pathology
KW - Transcription Factors
KW - Tumor Markers, Biological genetics
KW - Humans
KW - Prognosis
KW - DNA Mutational Analysis
KW - Neoplasm Proteins genetics
KW - Adenoma, Pleomorphic diagnosis
KW - Carcinoma, Acinar Cell
KW - Carcinoma, Adenoid Cystic
KW - Carcinoma, Mucoepidermoid diagnosis
KW - Chromosome Aberrations
KW - Comparative Genomic Hybridization
KW - DNA-Binding Proteins
KW - Gene Fusion
KW - HMGA2 Protein
KW - Nuclear Proteins
KW - Protein Array Analysis
KW - Salivary Gland Neoplasms diagnosis
KW - Salivary Glands pathology
KW - Transcription Factors
KW - Tumor Markers, Biological genetics
M3 - SCORING: Zeitschriftenaufsatz
VL - 30
SP - 466
EP - 471
JO - PATHOLOGE
JF - PATHOLOGE
SN - 0172-8113
IS - 6
M1 - 6
ER -
