Molecular characterization of chromosomal band 5p15.33: a recurrent breakpoint region in mantle cell lymphoma involving the TERT-CLPTM1L locus.
Standard
Molecular characterization of chromosomal band 5p15.33: a recurrent breakpoint region in mantle cell lymphoma involving the TERT-CLPTM1L locus. / Schilling, Georgia; Murga-Penas, Eva-Maria; Janjetovic, Snjezana; Oliveira Ferrer, Leticia; Balabanov, Melanie; Behrmann, Petra; Bokemeyer, Carsten; Dierlamm, Judith.
in: LEUKEMIA RES, Jahrgang 37, Nr. 3, 3, 2013, S. 280-286.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Molecular characterization of chromosomal band 5p15.33: a recurrent breakpoint region in mantle cell lymphoma involving the TERT-CLPTM1L locus.
AU - Schilling, Georgia
AU - Murga-Penas, Eva-Maria
AU - Janjetovic, Snjezana
AU - Oliveira Ferrer, Leticia
AU - Balabanov, Melanie
AU - Behrmann, Petra
AU - Bokemeyer, Carsten
AU - Dierlamm, Judith
N1 - Copyright © 2012 Elsevier Ltd. All rights reserved.
PY - 2013
Y1 - 2013
N2 - Secondary chromosomal aberrations may contribute to the development of a malignant phenotype in mantle cell lymphoma. Chromosomal band 5p15.33 represents a new recurrent breakpoint in B-cell malignancies. We present a molecular cytogenetic study of 8 mantle cell lymphoma (MCL) cell lines and 23 patients with MCL to determine and characterize novel secondary aberrations. We detected new secondary recurrent rearrangements in all cell lines and in 7 patients and confirmed 5p15.33 as a recurrent breakpoint in 4 cell lines and one patient. Further molecular characterization by flow-FISH and quantitative RT-PCR suggest TERT and CLPTM1L as target genes of 5p15.33 rearrangements.
AB - Secondary chromosomal aberrations may contribute to the development of a malignant phenotype in mantle cell lymphoma. Chromosomal band 5p15.33 represents a new recurrent breakpoint in B-cell malignancies. We present a molecular cytogenetic study of 8 mantle cell lymphoma (MCL) cell lines and 23 patients with MCL to determine and characterize novel secondary aberrations. We detected new secondary recurrent rearrangements in all cell lines and in 7 patients and confirmed 5p15.33 as a recurrent breakpoint in 4 cell lines and one patient. Further molecular characterization by flow-FISH and quantitative RT-PCR suggest TERT and CLPTM1L as target genes of 5p15.33 rearrangements.
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Prevalence
KW - DNA Mutational Analysis
KW - Reverse Transcriptase Polymerase Chain Reaction
KW - Cell Line, Tumor
KW - Gene Frequency
KW - In Situ Hybridization, Fluorescence
KW - Membrane Proteins/genetics
KW - Oncogene Proteins, Fusion/genetics
KW - Neoplasm Proteins/genetics
KW - Telomerase/genetics
KW - Chromosomes, Human, Pair 5/genetics
KW - Chromosome Banding
KW - Chromosome Breakage
KW - Genetic Loci/physiology
KW - Lymphoma, Mantle-Cell/epidemiology/genetics
KW - Translocation, Genetic/physiology
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Prevalence
KW - DNA Mutational Analysis
KW - Reverse Transcriptase Polymerase Chain Reaction
KW - Cell Line, Tumor
KW - Gene Frequency
KW - In Situ Hybridization, Fluorescence
KW - Membrane Proteins/genetics
KW - Oncogene Proteins, Fusion/genetics
KW - Neoplasm Proteins/genetics
KW - Telomerase/genetics
KW - Chromosomes, Human, Pair 5/genetics
KW - Chromosome Banding
KW - Chromosome Breakage
KW - Genetic Loci/physiology
KW - Lymphoma, Mantle-Cell/epidemiology/genetics
KW - Translocation, Genetic/physiology
U2 - 10.1016/j.leukres.2012.10.009
DO - 10.1016/j.leukres.2012.10.009
M3 - SCORING: Journal article
C2 - 23137523
VL - 37
SP - 280
EP - 286
JO - LEUKEMIA RES
JF - LEUKEMIA RES
SN - 0145-2126
IS - 3
M1 - 3
ER -
