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Modulation of Thrombosis Significantly Reduces Testicular Damage after Testicular Torsion in Rats: Anti-Thrombotic Treatment and Testicular Torsion

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Modulation of Thrombosis Significantly Reduces Testicular Damage after Testicular Torsion in Rats: Anti-Thrombotic Treatment and Testicular Torsion. / Boettcher, Michael; Fuchs, Tobias A; Schäfer, Hansjörg; Appl, Birgit; Trochimiuk, Magdalena; Jiménez-Alcázar, Miguel; Tiemann, Bastian; Jung, Roman; Bergholz, Robert; Reinshagen, Konrad; Eschenburg, Georg.

in: UROLOGY, Jahrgang 88, Nr. 227, 01.02.2016, S. e1-7.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Boettcher, M, Fuchs, TA, Schäfer, H, Appl, B, Trochimiuk, M, Jiménez-Alcázar, M, Tiemann, B, Jung, R, Bergholz, R, Reinshagen, K & Eschenburg, G 2016, 'Modulation of Thrombosis Significantly Reduces Testicular Damage after Testicular Torsion in Rats: Anti-Thrombotic Treatment and Testicular Torsion', UROLOGY, Jg. 88, Nr. 227, S. e1-7. https://doi.org/10.1016/j.urology.2015.11.004

APA

Boettcher, M., Fuchs, T. A., Schäfer, H., Appl, B., Trochimiuk, M., Jiménez-Alcázar, M., Tiemann, B., Jung, R., Bergholz, R., Reinshagen, K., & Eschenburg, G. (2016). Modulation of Thrombosis Significantly Reduces Testicular Damage after Testicular Torsion in Rats: Anti-Thrombotic Treatment and Testicular Torsion. UROLOGY, 88(227), e1-7. https://doi.org/10.1016/j.urology.2015.11.004

Vancouver

Boettcher M, Fuchs TA, Schäfer H, Appl B, Trochimiuk M, Jiménez-Alcázar M et al. Modulation of Thrombosis Significantly Reduces Testicular Damage after Testicular Torsion in Rats: Anti-Thrombotic Treatment and Testicular Torsion. UROLOGY. 2016 Feb 1;88(227):e1-7. https://doi.org/10.1016/j.urology.2015.11.004

Bibtex

@article{dfc644fad85b45b2a2e6de2ebf4afcb0,
title = "Modulation of Thrombosis Significantly Reduces Testicular Damage after Testicular Torsion in Rats: Anti-Thrombotic Treatment and Testicular Torsion",
abstract = "OBJECTIVE: It has been suggested that alterations of circulation during testicular torsion (TT) result in thrombus formation that might prevent sufficient perfusion after detorsion. Due to the narrow safety margin of testicular perfusion, even moderate disturbances in blood supply can cause major testicular damage. To evaluate the effects of thrombolysis and/or anticoagulation on testicular viability after TT was the aim of this study.METHODS: In 112 rats the right testicle was torsed for 3 or 6 hours. After detorsion and randomization, they received either enoxaparin / alteplase / both / placebo, according to their subgroup. Thrombus formation was accessed via D-Dimers, pDNA, oxidative testicular damage was evaluated via glutathione peroxidase and malondialdehyde, cellular damage via inhibin B, testosterone, histological analysis (Johnsen score, Cosetino grading) and TUNEL assay.RESULTS: One hundred and twelve rats were included in the study. The treatment with alteplase and/or enoxaparin showed significantly less testicular damage, and significantly improved Sertoli cell function. Enoxaparin significantly reduced oxidative impairment.CONCLUSION: The results of the study indicate that TT induces thrombus formation and demonstrate that modulation of thrombosis significantly ameliorates testicular damage in rats. Hence, this treatment option after TT ought to be evaluated in humans.",
author = "Michael Boettcher and Fuchs, {Tobias A} and Hansj{\"o}rg Sch{\"a}fer and Birgit Appl and Magdalena Trochimiuk and Miguel Jim{\'e}nez-Alc{\'a}zar and Bastian Tiemann and Roman Jung and Robert Bergholz and Konrad Reinshagen and Georg Eschenburg",
note = "Copyright {\textcopyright} 2015. Published by Elsevier Inc.",
year = "2016",
month = feb,
day = "1",
doi = "10.1016/j.urology.2015.11.004",
language = "English",
volume = "88",
pages = "e1--7",
journal = "UROLOGY",
issn = "0090-4295",
publisher = "Elsevier Inc.",
number = "227",

}

RIS

TY - JOUR

T1 - Modulation of Thrombosis Significantly Reduces Testicular Damage after Testicular Torsion in Rats: Anti-Thrombotic Treatment and Testicular Torsion

AU - Boettcher, Michael

AU - Fuchs, Tobias A

AU - Schäfer, Hansjörg

AU - Appl, Birgit

AU - Trochimiuk, Magdalena

AU - Jiménez-Alcázar, Miguel

AU - Tiemann, Bastian

AU - Jung, Roman

AU - Bergholz, Robert

AU - Reinshagen, Konrad

AU - Eschenburg, Georg

N1 - Copyright © 2015. Published by Elsevier Inc.

PY - 2016/2/1

Y1 - 2016/2/1

N2 - OBJECTIVE: It has been suggested that alterations of circulation during testicular torsion (TT) result in thrombus formation that might prevent sufficient perfusion after detorsion. Due to the narrow safety margin of testicular perfusion, even moderate disturbances in blood supply can cause major testicular damage. To evaluate the effects of thrombolysis and/or anticoagulation on testicular viability after TT was the aim of this study.METHODS: In 112 rats the right testicle was torsed for 3 or 6 hours. After detorsion and randomization, they received either enoxaparin / alteplase / both / placebo, according to their subgroup. Thrombus formation was accessed via D-Dimers, pDNA, oxidative testicular damage was evaluated via glutathione peroxidase and malondialdehyde, cellular damage via inhibin B, testosterone, histological analysis (Johnsen score, Cosetino grading) and TUNEL assay.RESULTS: One hundred and twelve rats were included in the study. The treatment with alteplase and/or enoxaparin showed significantly less testicular damage, and significantly improved Sertoli cell function. Enoxaparin significantly reduced oxidative impairment.CONCLUSION: The results of the study indicate that TT induces thrombus formation and demonstrate that modulation of thrombosis significantly ameliorates testicular damage in rats. Hence, this treatment option after TT ought to be evaluated in humans.

AB - OBJECTIVE: It has been suggested that alterations of circulation during testicular torsion (TT) result in thrombus formation that might prevent sufficient perfusion after detorsion. Due to the narrow safety margin of testicular perfusion, even moderate disturbances in blood supply can cause major testicular damage. To evaluate the effects of thrombolysis and/or anticoagulation on testicular viability after TT was the aim of this study.METHODS: In 112 rats the right testicle was torsed for 3 or 6 hours. After detorsion and randomization, they received either enoxaparin / alteplase / both / placebo, according to their subgroup. Thrombus formation was accessed via D-Dimers, pDNA, oxidative testicular damage was evaluated via glutathione peroxidase and malondialdehyde, cellular damage via inhibin B, testosterone, histological analysis (Johnsen score, Cosetino grading) and TUNEL assay.RESULTS: One hundred and twelve rats were included in the study. The treatment with alteplase and/or enoxaparin showed significantly less testicular damage, and significantly improved Sertoli cell function. Enoxaparin significantly reduced oxidative impairment.CONCLUSION: The results of the study indicate that TT induces thrombus formation and demonstrate that modulation of thrombosis significantly ameliorates testicular damage in rats. Hence, this treatment option after TT ought to be evaluated in humans.

U2 - 10.1016/j.urology.2015.11.004

DO - 10.1016/j.urology.2015.11.004

M3 - SCORING: Journal article

C2 - 26577621

VL - 88

SP - e1-7

JO - UROLOGY

JF - UROLOGY

SN - 0090-4295

IS - 227

ER -