Modulation of the immune response by systemic targeting of antigens to lymph nodes

M Trepel; Wadih Arap; Renata Pasqualini

Modulation of the immune response by systemic targeting of antigens to lymph nodes

Standard

Modulation of the immune response by systemic targeting of antigens to lymph nodes. / Trepel, M; Arap, Wadih; Pasqualini, Renata.

in: CANCER RES, Jahrgang 61, Nr. 22, 15.11.2001, S. 8110-2.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Trepel, M, Arap, W & Pasqualini, R 2001, 'Modulation of the immune response by systemic targeting of antigens to lymph nodes', CANCER RES, Jg. 61, Nr. 22, S. 8110-2.

APA

Trepel, M., Arap, W., & Pasqualini, R. (2001). Modulation of the immune response by systemic targeting of antigens to lymph nodes. CANCER RES, 61(22), 8110-2.

Vancouver

Trepel M, Arap W, Pasqualini R. Modulation of the immune response by systemic targeting of antigens to lymph nodes. CANCER RES. 2001 Nov 15;61(22):8110-2.

Bibtex

@article{508247a0a0aa4a53b53e89516d353548,

title = "Modulation of the immune response by systemic targeting of antigens to lymph nodes",

abstract = "Factors that determine the immunogenicity of an antigen in vivo are still largely unknown. Direct administration of antigens into lymphatic organs appears to enhance immune response. We hypothesized that systemically targeting antigens to lymphatic tissue in vivo might modulate immunity. To test this hypothesis, we measured the humoral immune response elicited by bacteriophage vaccination. We show that the responses against a lymph node-targeted phage are significantly higher than those against control untargeted phage; the effect is specific because it is inhibited by coadministration of the cognate synthetic peptides displayed. Our data suggest that systemic targeting of antigens to lymph nodes through the circulation modulates humoral immune response. This strategy may have broad applications in the development of vaccines, production of antibodies, and immunotherapy.",

keywords = "Animals, Antibody Formation, Bacteriophage M13, Endothelium, Vascular, Enzyme-Linked Immunosorbent Assay, Female, Lymph Nodes, Mice, Mice, Inbred BALB C, Mice, Nude, Oligopeptides, Vaccination, Journal Article, Research Support, Non-U.S. Gov't",

author = "M Trepel and Wadih Arap and Renata Pasqualini",

year = "2001",

month = nov,

day = "15",

language = "English",

volume = "61",

pages = "8110--2",

journal = "CANCER RES",

issn = "0008-5472",

publisher = "American Association for Cancer Research Inc.",

number = "22",

}

RIS

TY - JOUR

T1 - Modulation of the immune response by systemic targeting of antigens to lymph nodes

AU - Trepel, M

AU - Arap, Wadih

AU - Pasqualini, Renata

PY - 2001/11/15

Y1 - 2001/11/15

N2 - Factors that determine the immunogenicity of an antigen in vivo are still largely unknown. Direct administration of antigens into lymphatic organs appears to enhance immune response. We hypothesized that systemically targeting antigens to lymphatic tissue in vivo might modulate immunity. To test this hypothesis, we measured the humoral immune response elicited by bacteriophage vaccination. We show that the responses against a lymph node-targeted phage are significantly higher than those against control untargeted phage; the effect is specific because it is inhibited by coadministration of the cognate synthetic peptides displayed. Our data suggest that systemic targeting of antigens to lymph nodes through the circulation modulates humoral immune response. This strategy may have broad applications in the development of vaccines, production of antibodies, and immunotherapy.

AB - Factors that determine the immunogenicity of an antigen in vivo are still largely unknown. Direct administration of antigens into lymphatic organs appears to enhance immune response. We hypothesized that systemically targeting antigens to lymphatic tissue in vivo might modulate immunity. To test this hypothesis, we measured the humoral immune response elicited by bacteriophage vaccination. We show that the responses against a lymph node-targeted phage are significantly higher than those against control untargeted phage; the effect is specific because it is inhibited by coadministration of the cognate synthetic peptides displayed. Our data suggest that systemic targeting of antigens to lymph nodes through the circulation modulates humoral immune response. This strategy may have broad applications in the development of vaccines, production of antibodies, and immunotherapy.

KW - Animals

KW - Antibody Formation

KW - Bacteriophage M13

KW - Endothelium, Vascular

KW - Enzyme-Linked Immunosorbent Assay

KW - Female

KW - Lymph Nodes

KW - Mice

KW - Mice, Inbred BALB C

KW - Mice, Nude

KW - Oligopeptides

KW - Vaccination

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

M3 - SCORING: Journal article

C2 - 11719437

VL - 61

SP - 8110

EP - 8112

JO - CANCER RES

JF - CANCER RES

SN - 0008-5472

IS - 22

ER -