The combination of functional magnetic resonance imaging (fMRI) with computational models for a given cognitive process provides a powerful framework for testing hypotheses about the neural computations underlying such processes in the brain. Here, we outline the steps involved in implementing this approach with reference to the application of reinforcement learning (RL) models that can account for human choice behavior during value-based decision making. The model generates internal variables which can be used to construct fMRI predictor variables and regressed against individual subjects' fMRI data. The resulting regression coefficients reflect the strength of the correlation with blood oxygenation level dependent (BOLD) activity and the relevant internal variables from the model. In the second part of this review, we describe human neuroimaging studies that have employed this analysis strategy to identify brain regions involved in the computations mediating reward-related decision making. Copyright © 2010 John Wiley & Sons, Ltd. For further resources related to this article, please visit the WIREs website.
