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Mini-review : regulatory T cells and infection: suppression revisited. / Mittrücker, Hans-Willi; Kaufmann, Stefan H E.
in: EUR J IMMUNOL, Jahrgang 34, Nr. 2, 01.02.2004, S. 306-12.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Mini-review
T2 - regulatory T cells and infection: suppression revisited
AU - Mittrücker, Hans-Willi
AU - Kaufmann, Stefan H E
PY - 2004/2/1
Y1 - 2004/2/1
N2 - Within the last few years, regulatory T cells (T(reg) cells) have re-entered the stage of immunology. This astonishing revival is mainly due to recent studies on peripheral tolerance, which demonstrated the existence of T(reg) cells and allowed the isolation and phenotypic and functional characterization of these cells. However, information on the role of T(reg) cells in the control of immune responses against infections is still limited, although host defense represents the prime function of the immune system. In this overview, we summarize current knowledge on T(reg) cells in immunity to infection, discuss potential functions of T(reg) cells during infection, and finally, point to possible implications of T(reg) cell functions for our understanding of fundamental aspects of host-pathogen interactions.
AB - Within the last few years, regulatory T cells (T(reg) cells) have re-entered the stage of immunology. This astonishing revival is mainly due to recent studies on peripheral tolerance, which demonstrated the existence of T(reg) cells and allowed the isolation and phenotypic and functional characterization of these cells. However, information on the role of T(reg) cells in the control of immune responses against infections is still limited, although host defense represents the prime function of the immune system. In this overview, we summarize current knowledge on T(reg) cells in immunity to infection, discuss potential functions of T(reg) cells during infection, and finally, point to possible implications of T(reg) cell functions for our understanding of fundamental aspects of host-pathogen interactions.
KW - Animals
KW - CD4-Positive T-Lymphocytes
KW - Humans
KW - Infection
KW - Inflammatory Bowel Diseases
KW - Lymphocyte Activation
KW - Mice
KW - Parasitic Diseases
KW - T-Lymphocytes, Helper-Inducer
KW - Virus Diseases
U2 - 10.1002/eji.200324578
DO - 10.1002/eji.200324578
M3 - SCORING: Journal article
C2 - 14768034
VL - 34
SP - 306
EP - 312
JO - EUR J IMMUNOL
JF - EUR J IMMUNOL
SN - 0014-2980
IS - 2
ER -