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Mini-review : regulatory T cells and infection: suppression revisited. / Mittrücker, Hans-Willi; Kaufmann, Stefan H E.

in: EUR J IMMUNOL, Jahrgang 34, Nr. 2, 01.02.2004, S. 306-12.

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@article{5b8cafbc05b649328c05467e20100e9f,
title = "Mini-review: regulatory T cells and infection: suppression revisited",
abstract = "Within the last few years, regulatory T cells (T(reg) cells) have re-entered the stage of immunology. This astonishing revival is mainly due to recent studies on peripheral tolerance, which demonstrated the existence of T(reg) cells and allowed the isolation and phenotypic and functional characterization of these cells. However, information on the role of T(reg) cells in the control of immune responses against infections is still limited, although host defense represents the prime function of the immune system. In this overview, we summarize current knowledge on T(reg) cells in immunity to infection, discuss potential functions of T(reg) cells during infection, and finally, point to possible implications of T(reg) cell functions for our understanding of fundamental aspects of host-pathogen interactions.",
keywords = "Animals, CD4-Positive T-Lymphocytes, Humans, Infection, Inflammatory Bowel Diseases, Lymphocyte Activation, Mice, Parasitic Diseases, T-Lymphocytes, Helper-Inducer, Virus Diseases",
author = "Hans-Willi Mittr{\"u}cker and Kaufmann, {Stefan H E}",
year = "2004",
month = feb,
day = "1",
doi = "10.1002/eji.200324578",
language = "English",
volume = "34",
pages = "306--12",
journal = "EUR J IMMUNOL",
issn = "0014-2980",
publisher = "Wiley-VCH Verlag GmbH",
number = "2",

}

RIS

TY - JOUR

T1 - Mini-review

T2 - regulatory T cells and infection: suppression revisited

AU - Mittrücker, Hans-Willi

AU - Kaufmann, Stefan H E

PY - 2004/2/1

Y1 - 2004/2/1

N2 - Within the last few years, regulatory T cells (T(reg) cells) have re-entered the stage of immunology. This astonishing revival is mainly due to recent studies on peripheral tolerance, which demonstrated the existence of T(reg) cells and allowed the isolation and phenotypic and functional characterization of these cells. However, information on the role of T(reg) cells in the control of immune responses against infections is still limited, although host defense represents the prime function of the immune system. In this overview, we summarize current knowledge on T(reg) cells in immunity to infection, discuss potential functions of T(reg) cells during infection, and finally, point to possible implications of T(reg) cell functions for our understanding of fundamental aspects of host-pathogen interactions.

AB - Within the last few years, regulatory T cells (T(reg) cells) have re-entered the stage of immunology. This astonishing revival is mainly due to recent studies on peripheral tolerance, which demonstrated the existence of T(reg) cells and allowed the isolation and phenotypic and functional characterization of these cells. However, information on the role of T(reg) cells in the control of immune responses against infections is still limited, although host defense represents the prime function of the immune system. In this overview, we summarize current knowledge on T(reg) cells in immunity to infection, discuss potential functions of T(reg) cells during infection, and finally, point to possible implications of T(reg) cell functions for our understanding of fundamental aspects of host-pathogen interactions.

KW - Animals

KW - CD4-Positive T-Lymphocytes

KW - Humans

KW - Infection

KW - Inflammatory Bowel Diseases

KW - Lymphocyte Activation

KW - Mice

KW - Parasitic Diseases

KW - T-Lymphocytes, Helper-Inducer

KW - Virus Diseases

U2 - 10.1002/eji.200324578

DO - 10.1002/eji.200324578

M3 - SCORING: Journal article

C2 - 14768034

VL - 34

SP - 306

EP - 312

JO - EUR J IMMUNOL

JF - EUR J IMMUNOL

SN - 0014-2980

IS - 2

ER -