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Mineralocorticoid receptor function in posttraumatic stress disorder after pretreatment with metyrapone.

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Mineralocorticoid receptor function in posttraumatic stress disorder after pretreatment with metyrapone. / Otte, Christian; Muhtz, Christoph; Daneshkhah, Sima; Yassouridis, Alexander; Kiefer, Falk; Wiedemann, Klaus; Kellner, Michael.

in: BIOL PSYCHIAT, Jahrgang 60, Nr. 7, 7, 2006, S. 784-787.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Otte, C, Muhtz, C, Daneshkhah, S, Yassouridis, A, Kiefer, F, Wiedemann, K & Kellner, M 2006, 'Mineralocorticoid receptor function in posttraumatic stress disorder after pretreatment with metyrapone.', BIOL PSYCHIAT, Jg. 60, Nr. 7, 7, S. 784-787. <http://www.ncbi.nlm.nih.gov/pubmed/16566900?dopt=Citation>

APA

Otte, C., Muhtz, C., Daneshkhah, S., Yassouridis, A., Kiefer, F., Wiedemann, K., & Kellner, M. (2006). Mineralocorticoid receptor function in posttraumatic stress disorder after pretreatment with metyrapone. BIOL PSYCHIAT, 60(7), 784-787. [7]. http://www.ncbi.nlm.nih.gov/pubmed/16566900?dopt=Citation

Vancouver

Otte C, Muhtz C, Daneshkhah S, Yassouridis A, Kiefer F, Wiedemann K et al. Mineralocorticoid receptor function in posttraumatic stress disorder after pretreatment with metyrapone. BIOL PSYCHIAT. 2006;60(7):784-787. 7.

Bibtex

@article{a484506679b54f1e9b6626a14ea3183f,
title = "Mineralocorticoid receptor function in posttraumatic stress disorder after pretreatment with metyrapone.",
abstract = "BACKGROUND: Alterations of mineralocorticoid receptor (MR) mediated negative feedback inhibition of cortisol might contribute to abnormalities of hypothalamic-pituitary adrenal (HPA) activity in posttraumatic stress disorder (PTSD). METHODS: In a placebo-controlled study, we examined 11 subjects with PTSD and 11 healthy controls between 14:00 and 21:00. After pretreatment with 3 g metyrapone to inhibit basal endogenous cortisol secretion, subjects orally received in randomized order .5 mg of the MR agonist fludrocortisone or placebo. Adrenocorticotropic hormone (ACTH), cortisol, and 11-deoxycortisol were measured every 30 min until 21:00. RESULTS: Compared to placebo, fludrocortisone led to a significant decrease of ACTH and cortisol that was similar in both groups. Subjects with PTSD had higher raw cortisol and higher normed (baseline-related) ACTH and 11-deoxycortisol values after metyrapone independent of treatment with fludrocortisone or placebo. CONCLUSIONS: While HPA responses after metyrapone seem to be stronger in PTSD compared to controls, no alterations of mineralocorticoid receptor function in PTSD were found in this study.",
author = "Christian Otte and Christoph Muhtz and Sima Daneshkhah and Alexander Yassouridis and Falk Kiefer and Klaus Wiedemann and Michael Kellner",
year = "2006",
language = "Deutsch",
volume = "60",
pages = "784--787",
journal = "BIOL PSYCHIAT",
issn = "0006-3223",
publisher = "Elsevier USA",
number = "7",

}

RIS

TY - JOUR

T1 - Mineralocorticoid receptor function in posttraumatic stress disorder after pretreatment with metyrapone.

AU - Otte, Christian

AU - Muhtz, Christoph

AU - Daneshkhah, Sima

AU - Yassouridis, Alexander

AU - Kiefer, Falk

AU - Wiedemann, Klaus

AU - Kellner, Michael

PY - 2006

Y1 - 2006

N2 - BACKGROUND: Alterations of mineralocorticoid receptor (MR) mediated negative feedback inhibition of cortisol might contribute to abnormalities of hypothalamic-pituitary adrenal (HPA) activity in posttraumatic stress disorder (PTSD). METHODS: In a placebo-controlled study, we examined 11 subjects with PTSD and 11 healthy controls between 14:00 and 21:00. After pretreatment with 3 g metyrapone to inhibit basal endogenous cortisol secretion, subjects orally received in randomized order .5 mg of the MR agonist fludrocortisone or placebo. Adrenocorticotropic hormone (ACTH), cortisol, and 11-deoxycortisol were measured every 30 min until 21:00. RESULTS: Compared to placebo, fludrocortisone led to a significant decrease of ACTH and cortisol that was similar in both groups. Subjects with PTSD had higher raw cortisol and higher normed (baseline-related) ACTH and 11-deoxycortisol values after metyrapone independent of treatment with fludrocortisone or placebo. CONCLUSIONS: While HPA responses after metyrapone seem to be stronger in PTSD compared to controls, no alterations of mineralocorticoid receptor function in PTSD were found in this study.

AB - BACKGROUND: Alterations of mineralocorticoid receptor (MR) mediated negative feedback inhibition of cortisol might contribute to abnormalities of hypothalamic-pituitary adrenal (HPA) activity in posttraumatic stress disorder (PTSD). METHODS: In a placebo-controlled study, we examined 11 subjects with PTSD and 11 healthy controls between 14:00 and 21:00. After pretreatment with 3 g metyrapone to inhibit basal endogenous cortisol secretion, subjects orally received in randomized order .5 mg of the MR agonist fludrocortisone or placebo. Adrenocorticotropic hormone (ACTH), cortisol, and 11-deoxycortisol were measured every 30 min until 21:00. RESULTS: Compared to placebo, fludrocortisone led to a significant decrease of ACTH and cortisol that was similar in both groups. Subjects with PTSD had higher raw cortisol and higher normed (baseline-related) ACTH and 11-deoxycortisol values after metyrapone independent of treatment with fludrocortisone or placebo. CONCLUSIONS: While HPA responses after metyrapone seem to be stronger in PTSD compared to controls, no alterations of mineralocorticoid receptor function in PTSD were found in this study.

M3 - SCORING: Zeitschriftenaufsatz

VL - 60

SP - 784

EP - 787

JO - BIOL PSYCHIAT

JF - BIOL PSYCHIAT

SN - 0006-3223

IS - 7

M1 - 7

ER -