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Miliary never-smoking adenocarcinoma of the lung: strong association with epidermal growth factor receptor exon 19 deletion.

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Miliary never-smoking adenocarcinoma of the lung: strong association with epidermal growth factor receptor exon 19 deletion. / Laack, Eckart; Simon, Ronald; Regier, Marc; Andritzky, Birte; Tennstedt, Pierre; Habermann, Christian; Verth, Christoph Zur; Thoem, Ina; Grob, Tobias; Sauter, Guido; Bokemeyer, Carsten.

in: J THORAC ONCOL, Jahrgang 6, Nr. 1, 1, 01.01.2011, S. 199-202.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Laack, E, Simon, R, Regier, M, Andritzky, B, Tennstedt, P, Habermann, C, Verth, CZ, Thoem, I, Grob, T, Sauter, G & Bokemeyer, C 2011, 'Miliary never-smoking adenocarcinoma of the lung: strong association with epidermal growth factor receptor exon 19 deletion.', J THORAC ONCOL, Jg. 6, Nr. 1, 1, S. 199-202. https://doi.org/10.1097/JTO.0b013e3181fb7cf1

APA

Laack, E., Simon, R., Regier, M., Andritzky, B., Tennstedt, P., Habermann, C., Verth, C. Z., Thoem, I., Grob, T., Sauter, G., & Bokemeyer, C. (2011). Miliary never-smoking adenocarcinoma of the lung: strong association with epidermal growth factor receptor exon 19 deletion. J THORAC ONCOL, 6(1), 199-202. [1]. https://doi.org/10.1097/JTO.0b013e3181fb7cf1

Vancouver

Laack E, Simon R, Regier M, Andritzky B, Tennstedt P, Habermann C et al. Miliary never-smoking adenocarcinoma of the lung: strong association with epidermal growth factor receptor exon 19 deletion. J THORAC ONCOL. 2011 Jan 1;6(1):199-202. 1. https://doi.org/10.1097/JTO.0b013e3181fb7cf1

Bibtex

@article{00277cb9c1b9488d829333101538d95d,
title = "Miliary never-smoking adenocarcinoma of the lung: strong association with epidermal growth factor receptor exon 19 deletion.",
abstract = "Miliary pattern of pulmonary metastases is a rarity in patients with lung cancer. We report five cases of patients with a never-smoking adenocarcinoma of the lung with such a pattern of metastases. In the tumor cells of all five patients, epidermal growth factor receptor (EGFR) mutation gene sequencing identified a deletion in exon 19 of the EGFR gene, and all five patients had a dramatic response to EGFR tyrosine kinase inhibitors. No echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) translocation was detected. We believe that the miliary never-soking adenocarcinoma of the lung is a distinct clinically relevant subgroup of the never-smoking non-small cell lung cancer. Physician should recognize this subgroup of patients with lung cancer when facing a picture of miliary pulmonary metastases in chest x-ray or computed tomography scan in patients with a history of never smoking and consider upfront therapy with EGFR tyrosine kinase inhibitors.",
keywords = "Adult, Humans, Male, Aged, Female, Middle Aged, Prognosis, Neoplasm Staging, Translocation, Genetic, Polymerase Chain Reaction, DNA, Neoplasm/genetics, Oncogene Proteins, Fusion/genetics, Mutation/*genetics, Bone Neoplasms/genetics/secondary, Brain Neoplasms/genetics/secondary, Carcinoma, Acinar Cell/*genetics/secondary, Exons/*genetics, Lung Neoplasms/*genetics/pathology, Receptor, Epidermal Growth Factor/*genetics, *Sequence Deletion, *Smoking, Adult, Humans, Male, Aged, Female, Middle Aged, Prognosis, Neoplasm Staging, Translocation, Genetic, Polymerase Chain Reaction, DNA, Neoplasm/genetics, Oncogene Proteins, Fusion/genetics, Mutation/*genetics, Bone Neoplasms/genetics/secondary, Brain Neoplasms/genetics/secondary, Carcinoma, Acinar Cell/*genetics/secondary, Exons/*genetics, Lung Neoplasms/*genetics/pathology, Receptor, Epidermal Growth Factor/*genetics, *Sequence Deletion, *Smoking",
author = "Eckart Laack and Ronald Simon and Marc Regier and Birte Andritzky and Pierre Tennstedt and Christian Habermann and Verth, {Christoph Zur} and Ina Thoem and Tobias Grob and Guido Sauter and Carsten Bokemeyer",
year = "2011",
month = jan,
day = "1",
doi = "10.1097/JTO.0b013e3181fb7cf1",
language = "English",
volume = "6",
pages = "199--202",
journal = "J THORAC ONCOL",
issn = "1556-0864",
publisher = "International Association for the Study of Lung Cancer",
number = "1",

}

RIS

TY - JOUR

T1 - Miliary never-smoking adenocarcinoma of the lung: strong association with epidermal growth factor receptor exon 19 deletion.

AU - Laack, Eckart

AU - Simon, Ronald

AU - Regier, Marc

AU - Andritzky, Birte

AU - Tennstedt, Pierre

AU - Habermann, Christian

AU - Verth, Christoph Zur

AU - Thoem, Ina

AU - Grob, Tobias

AU - Sauter, Guido

AU - Bokemeyer, Carsten

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Miliary pattern of pulmonary metastases is a rarity in patients with lung cancer. We report five cases of patients with a never-smoking adenocarcinoma of the lung with such a pattern of metastases. In the tumor cells of all five patients, epidermal growth factor receptor (EGFR) mutation gene sequencing identified a deletion in exon 19 of the EGFR gene, and all five patients had a dramatic response to EGFR tyrosine kinase inhibitors. No echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) translocation was detected. We believe that the miliary never-soking adenocarcinoma of the lung is a distinct clinically relevant subgroup of the never-smoking non-small cell lung cancer. Physician should recognize this subgroup of patients with lung cancer when facing a picture of miliary pulmonary metastases in chest x-ray or computed tomography scan in patients with a history of never smoking and consider upfront therapy with EGFR tyrosine kinase inhibitors.

AB - Miliary pattern of pulmonary metastases is a rarity in patients with lung cancer. We report five cases of patients with a never-smoking adenocarcinoma of the lung with such a pattern of metastases. In the tumor cells of all five patients, epidermal growth factor receptor (EGFR) mutation gene sequencing identified a deletion in exon 19 of the EGFR gene, and all five patients had a dramatic response to EGFR tyrosine kinase inhibitors. No echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) translocation was detected. We believe that the miliary never-soking adenocarcinoma of the lung is a distinct clinically relevant subgroup of the never-smoking non-small cell lung cancer. Physician should recognize this subgroup of patients with lung cancer when facing a picture of miliary pulmonary metastases in chest x-ray or computed tomography scan in patients with a history of never smoking and consider upfront therapy with EGFR tyrosine kinase inhibitors.

KW - Adult

KW - Humans

KW - Male

KW - Aged

KW - Female

KW - Middle Aged

KW - Prognosis

KW - Neoplasm Staging

KW - Translocation, Genetic

KW - Polymerase Chain Reaction

KW - DNA, Neoplasm/genetics

KW - Oncogene Proteins, Fusion/genetics

KW - Mutation/genetics

KW - Bone Neoplasms/genetics/secondary

KW - Brain Neoplasms/genetics/secondary

KW - Carcinoma, Acinar Cell/genetics/secondary

KW - Exons/genetics

KW - Lung Neoplasms/genetics/pathology

KW - Receptor, Epidermal Growth Factor/genetics

KW - Sequence Deletion

KW - Smoking

KW - Adult

KW - Humans

KW - Male

KW - Aged

KW - Female

KW - Middle Aged

KW - Prognosis

KW - Neoplasm Staging

KW - Translocation, Genetic

KW - Polymerase Chain Reaction

KW - DNA, Neoplasm/genetics

KW - Oncogene Proteins, Fusion/genetics

KW - Mutation/genetics

KW - Bone Neoplasms/genetics/secondary

KW - Brain Neoplasms/genetics/secondary

KW - Carcinoma, Acinar Cell/genetics/secondary

KW - Exons/genetics

KW - Lung Neoplasms/genetics/pathology

KW - Receptor, Epidermal Growth Factor/genetics

KW - Sequence Deletion

KW - Smoking

U2 - 10.1097/JTO.0b013e3181fb7cf1

DO - 10.1097/JTO.0b013e3181fb7cf1

M3 - SCORING: Journal article

C2 - 21178715

VL - 6

SP - 199

EP - 202

JO - J THORAC ONCOL

JF - J THORAC ONCOL

SN - 1556-0864

IS - 1

M1 - 1

ER -