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Midregional pro-atrial natriuretic peptide in the general population/Insights from the Gutenberg Health Study

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Midregional pro-atrial natriuretic peptide in the general population/Insights from the Gutenberg Health Study. / Tzikas, Stergios; Keller, Till; Wild, Philipp S; Schulz, Andreas; Zwiener, Isabella; Zeller, Tanja; Schnabel, Renate B; Sinning, Christoph; Lubos, Edith; Kunde, Jan; Münzel, Thomas; Lackner, Karl J; Blankenberg, Stefan.

in: CLIN CHEM LAB MED, Jahrgang 51, Nr. 5, 05.2013, S. 1125-1133.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Tzikas, S, Keller, T, Wild, PS, Schulz, A, Zwiener, I, Zeller, T, Schnabel, RB, Sinning, C, Lubos, E, Kunde, J, Münzel, T, Lackner, KJ & Blankenberg, S 2013, 'Midregional pro-atrial natriuretic peptide in the general population/Insights from the Gutenberg Health Study', CLIN CHEM LAB MED, Jg. 51, Nr. 5, S. 1125-1133. https://doi.org/10.1515/cclm-2012-0541

APA

Tzikas, S., Keller, T., Wild, P. S., Schulz, A., Zwiener, I., Zeller, T., Schnabel, R. B., Sinning, C., Lubos, E., Kunde, J., Münzel, T., Lackner, K. J., & Blankenberg, S. (2013). Midregional pro-atrial natriuretic peptide in the general population/Insights from the Gutenberg Health Study. CLIN CHEM LAB MED, 51(5), 1125-1133. https://doi.org/10.1515/cclm-2012-0541

Vancouver

Tzikas S, Keller T, Wild PS, Schulz A, Zwiener I, Zeller T et al. Midregional pro-atrial natriuretic peptide in the general population/Insights from the Gutenberg Health Study. CLIN CHEM LAB MED. 2013 Mai;51(5):1125-1133. https://doi.org/10.1515/cclm-2012-0541

Bibtex

@article{0ec6feeac421490b87f962ac07477873,
title = "Midregional pro-atrial natriuretic peptide in the general population/Insights from the Gutenberg Health Study",
abstract = "BACKGROUND: The use of biomarkers is firmly established for the assessment of cardiovascular disease. Emerging biomarkers such as midregional pro-atrial natriuretic peptide (MR-proANP) challenge established markers regarding risk prediction and stratification ability. The aim of the present study was to describe the distribution of a contemporary MR-proANP assay in a large population-representative sample and to evaluate the association with prevalent cardiac diseases and cardiovascular risk factors.METHODS: MR-proANP was determined by the use of a contemporary commercially available assay (BRAHMS GmbH, Hennigsdorf, Germany) in a representative sample of 5000 participants from the large population-based Gutenberg Health Study. N-terminal pro B-type natriuretic peptide (NT-proBNP) was used as a comparator.RESULTS: Mean age was 55.5 ± 10.9 years. Coronary artery disease (CAD) was documented in 4.6%, heart failure (HF) in 1.5% of the study participants. We observed a moderate to strong correlation of the biomarkers with age, diabetes, hypertension, smoking, renal function, prevalence of CAD and HF. Males showed lower MR-proANP concentrations than females. MR-proANP showed no relevant correlation with BMI (ρ=-0.030) and CRP (ρ=0.039). Reference limits for MR-proANP representing the 95th/97.5th/99th percentile were determined for healthy individuals with 116/132/169 pmol/mL.CONCLUSIONS: The current analysis in a large population-based sample elucidates the correlations and distribution of MR-proANP. Its concentration in healthy individuals depends on prevalent cardiovascular diseases and classical risk factors. The reported population-based reference values might be useful for distinguishing between healthy and diseased individuals, thus improving risk stratification and triaging in various clinical settings.",
keywords = "Adult, Aged, Atrial Natriuretic Factor/blood, Biomarkers/blood, Blood Chemical Analysis, Cohort Studies, Cross-Sectional Studies, Female, Germany/epidemiology, Humans, Male, Middle Aged",
author = "Stergios Tzikas and Till Keller and Wild, {Philipp S} and Andreas Schulz and Isabella Zwiener and Tanja Zeller and Schnabel, {Renate B} and Christoph Sinning and Edith Lubos and Jan Kunde and Thomas M{\"u}nzel and Lackner, {Karl J} and Stefan Blankenberg",
year = "2013",
month = may,
doi = "10.1515/cclm-2012-0541",
language = "English",
volume = "51",
pages = "1125--1133",
journal = "CLIN CHEM LAB MED",
issn = "1434-6621",
publisher = "Walter de Gruyter GmbH & Co. KG",
number = "5",

}

RIS

TY - JOUR

T1 - Midregional pro-atrial natriuretic peptide in the general population/Insights from the Gutenberg Health Study

AU - Tzikas, Stergios

AU - Keller, Till

AU - Wild, Philipp S

AU - Schulz, Andreas

AU - Zwiener, Isabella

AU - Zeller, Tanja

AU - Schnabel, Renate B

AU - Sinning, Christoph

AU - Lubos, Edith

AU - Kunde, Jan

AU - Münzel, Thomas

AU - Lackner, Karl J

AU - Blankenberg, Stefan

PY - 2013/5

Y1 - 2013/5

N2 - BACKGROUND: The use of biomarkers is firmly established for the assessment of cardiovascular disease. Emerging biomarkers such as midregional pro-atrial natriuretic peptide (MR-proANP) challenge established markers regarding risk prediction and stratification ability. The aim of the present study was to describe the distribution of a contemporary MR-proANP assay in a large population-representative sample and to evaluate the association with prevalent cardiac diseases and cardiovascular risk factors.METHODS: MR-proANP was determined by the use of a contemporary commercially available assay (BRAHMS GmbH, Hennigsdorf, Germany) in a representative sample of 5000 participants from the large population-based Gutenberg Health Study. N-terminal pro B-type natriuretic peptide (NT-proBNP) was used as a comparator.RESULTS: Mean age was 55.5 ± 10.9 years. Coronary artery disease (CAD) was documented in 4.6%, heart failure (HF) in 1.5% of the study participants. We observed a moderate to strong correlation of the biomarkers with age, diabetes, hypertension, smoking, renal function, prevalence of CAD and HF. Males showed lower MR-proANP concentrations than females. MR-proANP showed no relevant correlation with BMI (ρ=-0.030) and CRP (ρ=0.039). Reference limits for MR-proANP representing the 95th/97.5th/99th percentile were determined for healthy individuals with 116/132/169 pmol/mL.CONCLUSIONS: The current analysis in a large population-based sample elucidates the correlations and distribution of MR-proANP. Its concentration in healthy individuals depends on prevalent cardiovascular diseases and classical risk factors. The reported population-based reference values might be useful for distinguishing between healthy and diseased individuals, thus improving risk stratification and triaging in various clinical settings.

AB - BACKGROUND: The use of biomarkers is firmly established for the assessment of cardiovascular disease. Emerging biomarkers such as midregional pro-atrial natriuretic peptide (MR-proANP) challenge established markers regarding risk prediction and stratification ability. The aim of the present study was to describe the distribution of a contemporary MR-proANP assay in a large population-representative sample and to evaluate the association with prevalent cardiac diseases and cardiovascular risk factors.METHODS: MR-proANP was determined by the use of a contemporary commercially available assay (BRAHMS GmbH, Hennigsdorf, Germany) in a representative sample of 5000 participants from the large population-based Gutenberg Health Study. N-terminal pro B-type natriuretic peptide (NT-proBNP) was used as a comparator.RESULTS: Mean age was 55.5 ± 10.9 years. Coronary artery disease (CAD) was documented in 4.6%, heart failure (HF) in 1.5% of the study participants. We observed a moderate to strong correlation of the biomarkers with age, diabetes, hypertension, smoking, renal function, prevalence of CAD and HF. Males showed lower MR-proANP concentrations than females. MR-proANP showed no relevant correlation with BMI (ρ=-0.030) and CRP (ρ=0.039). Reference limits for MR-proANP representing the 95th/97.5th/99th percentile were determined for healthy individuals with 116/132/169 pmol/mL.CONCLUSIONS: The current analysis in a large population-based sample elucidates the correlations and distribution of MR-proANP. Its concentration in healthy individuals depends on prevalent cardiovascular diseases and classical risk factors. The reported population-based reference values might be useful for distinguishing between healthy and diseased individuals, thus improving risk stratification and triaging in various clinical settings.

KW - Adult

KW - Aged

KW - Atrial Natriuretic Factor/blood

KW - Biomarkers/blood

KW - Blood Chemical Analysis

KW - Cohort Studies

KW - Cross-Sectional Studies

KW - Female

KW - Germany/epidemiology

KW - Humans

KW - Male

KW - Middle Aged

U2 - 10.1515/cclm-2012-0541

DO - 10.1515/cclm-2012-0541

M3 - SCORING: Journal article

C2 - 23183754

VL - 51

SP - 1125

EP - 1133

JO - CLIN CHEM LAB MED

JF - CLIN CHEM LAB MED

SN - 1434-6621

IS - 5

ER -