Midregional proadrenomedullin and growth differentiation factor-15 are not influenced by obesity in heart failure patients
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Midregional proadrenomedullin and growth differentiation factor-15 are not influenced by obesity in heart failure patients. / Sinning, Christoph; Ojeda, Francisco; Wild, Philipp S; Schnabel, Renate B; Schwarzl, Michael; Ohdah, Sevenai; Lackner, Karl J; Pfeiffer, Norbert; Michal, Matthias; Blettner, Maria; Munzel, Thomas; Kempf, Tibor; Wollert, Kai C; Kuulasmaa, Kari; Blankenberg, Stefan; Salomaa, Veikko; Westermann, Dirk; Zeller, Tanja.
in: CLIN RES CARDIOL, Jahrgang 106, Nr. 6, 06.2017, S. 401-410.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Midregional proadrenomedullin and growth differentiation factor-15 are not influenced by obesity in heart failure patients
AU - Sinning, Christoph
AU - Ojeda, Francisco
AU - Wild, Philipp S
AU - Schnabel, Renate B
AU - Schwarzl, Michael
AU - Ohdah, Sevenai
AU - Lackner, Karl J
AU - Pfeiffer, Norbert
AU - Michal, Matthias
AU - Blettner, Maria
AU - Munzel, Thomas
AU - Kempf, Tibor
AU - Wollert, Kai C
AU - Kuulasmaa, Kari
AU - Blankenberg, Stefan
AU - Salomaa, Veikko
AU - Westermann, Dirk
AU - Zeller, Tanja
PY - 2017/6
Y1 - 2017/6
N2 - BACKGROUND: Obesity is a risk factor for heart failure (HF) and identification of symptomatic, and obese HF patients are challenging, because obesity can mimic HF symptoms. We aimed to evaluate novel biomarkers for HF in obese subjects of the general population.METHODS: Midregional proadrenomedullin (MR-proADM), growth differentiation factor-15 (GDF-15), midregional pro-atrial natriuretic peptide (MR-proANP), and NT-proBNP were measured in 5000 individuals of the population-based Gutenberg Health Study (GHS), including 1204 obese individuals (BMI ≥ 30 kg/m2) and 107 individuals with HF.RESULTS: NT-proBNP and MR-proANP were lower in obese vs. non-obese HF individuals (p = 0.013 and p = 0.01, respectively), whereas GDF-15 was similar and MR-proADM was higher in obese vs. non-obese HF individuals. All biomarkers increased the odds ratio (OR) for prevalent HF. For NT-proBNP and MR-proANP, this increase was lower in obese vs. non-obese individuals, whereas it was comparable for MR-proADM and GDF-15. All biomarkers were associated with increased all-cause mortality (median follow-up 7.3 years, 211 events). Results were validated in 8373 individuals (n = 1734 with BMI ≥ 30 kg/m2) of the FINRISK study with a median follow-up of 13.8 years (1030 events). Using a dichotomized biomarker cutoff for HF, the best predictor for all-cause mortality in obese subjects was GDF-15 (p < 0.001).CONCLUSION: All biomarkers were associated with HF and higher risk for all-cause mortality in the general population. In contrast to the natriuretic peptides NT-proBNP and MR-proANP, the novel biomarkers MR-proADM and GDF-15 were not lower in obese HF individuals, indicating their potential to facilitate HF diagnosis and prognosis in an increasingly obese HF population.
AB - BACKGROUND: Obesity is a risk factor for heart failure (HF) and identification of symptomatic, and obese HF patients are challenging, because obesity can mimic HF symptoms. We aimed to evaluate novel biomarkers for HF in obese subjects of the general population.METHODS: Midregional proadrenomedullin (MR-proADM), growth differentiation factor-15 (GDF-15), midregional pro-atrial natriuretic peptide (MR-proANP), and NT-proBNP were measured in 5000 individuals of the population-based Gutenberg Health Study (GHS), including 1204 obese individuals (BMI ≥ 30 kg/m2) and 107 individuals with HF.RESULTS: NT-proBNP and MR-proANP were lower in obese vs. non-obese HF individuals (p = 0.013 and p = 0.01, respectively), whereas GDF-15 was similar and MR-proADM was higher in obese vs. non-obese HF individuals. All biomarkers increased the odds ratio (OR) for prevalent HF. For NT-proBNP and MR-proANP, this increase was lower in obese vs. non-obese individuals, whereas it was comparable for MR-proADM and GDF-15. All biomarkers were associated with increased all-cause mortality (median follow-up 7.3 years, 211 events). Results were validated in 8373 individuals (n = 1734 with BMI ≥ 30 kg/m2) of the FINRISK study with a median follow-up of 13.8 years (1030 events). Using a dichotomized biomarker cutoff for HF, the best predictor for all-cause mortality in obese subjects was GDF-15 (p < 0.001).CONCLUSION: All biomarkers were associated with HF and higher risk for all-cause mortality in the general population. In contrast to the natriuretic peptides NT-proBNP and MR-proANP, the novel biomarkers MR-proADM and GDF-15 were not lower in obese HF individuals, indicating their potential to facilitate HF diagnosis and prognosis in an increasingly obese HF population.
KW - Adrenomedullin/blood
KW - Aged
KW - Atrial Natriuretic Factor/blood
KW - Biomarkers/blood
KW - Cohort Studies
KW - Female
KW - Follow-Up Studies
KW - Growth Differentiation Factor 15/blood
KW - Heart Failure/blood
KW - Humans
KW - Male
KW - Middle Aged
KW - Natriuretic Peptide, Brain/blood
KW - Obesity/blood
KW - Peptide Fragments/blood
KW - Prognosis
KW - Prospective Studies
KW - Protein Precursors/blood
KW - Risk Factors
U2 - 10.1007/s00392-016-1066-x
DO - 10.1007/s00392-016-1066-x
M3 - SCORING: Journal article
C2 - 28004184
VL - 106
SP - 401
EP - 410
JO - CLIN RES CARDIOL
JF - CLIN RES CARDIOL
SN - 1861-0684
IS - 6
ER -
