Microscopic colitis: pathophysiology and clinical management

Stephan Miehlke; Bas Verhaegh; Gian Eugenio Tontini; Ahmed Madisch; Cord Langner; Andreas Münch

doi:10.1016/S2468-1253(19)30048-2

Microscopic colitis

Standard

Microscopic colitis : pathophysiology and clinical management. / Miehlke, Stephan; Verhaegh, Bas; Tontini, Gian Eugenio; Madisch, Ahmed; Langner, Cord; Münch, Andreas.

in: LANCET GASTROENTEROL, Jahrgang 4, Nr. 4, 04.2019, S. 305-314.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Miehlke, S, Verhaegh, B, Tontini, GE, Madisch, A, Langner, C & Münch, A 2019, 'Microscopic colitis: pathophysiology and clinical management', LANCET GASTROENTEROL, Jg. 4, Nr. 4, S. 305-314. https://doi.org/10.1016/S2468-1253(19)30048-2

APA

Miehlke, S., Verhaegh, B., Tontini, G. E., Madisch, A., Langner, C., & Münch, A. (2019). Microscopic colitis: pathophysiology and clinical management. LANCET GASTROENTEROL, 4(4), 305-314. https://doi.org/10.1016/S2468-1253(19)30048-2

Vancouver

Miehlke S, Verhaegh B, Tontini GE, Madisch A, Langner C, Münch A. Microscopic colitis: pathophysiology and clinical management. LANCET GASTROENTEROL. 2019 Apr;4(4):305-314. https://doi.org/10.1016/S2468-1253(19)30048-2

Bibtex

@article{d52580d9b3f04f09ac8b93982788029f,

title = "Microscopic colitis: pathophysiology and clinical management",

abstract = "Microscopic colitis is a chronic inflammatory disease of the colon that frequently causes chronic watery diarrhoea that might be accompanied by abdominal pain, nocturnal diarrhoea, urgency, and faecal incontinence. These symptoms lead to poor quality of life and increased health-care costs. Diagnosis relies on histological examination of multiple biopsy samples from the colonic mucosa, which often show no or only few abnormalities on endoscopy. Two major histological subtypes can be distinguished-collagenous colitis and lymphocytic colitis-but incomplete and variant forms with fewer characteristic features have been reported. Here we summarise the latest evidence on epidemiology, pathogenesis, and risk factors, and discuss established and novel therapeutic options for clinical remission. Finally, we propose an updated treatment algorithm. Further prospective studies are needed to clarify the natural history of microscopic colitis, supported by validated criteria for the assessment of disease activity.",

author = "Stephan Miehlke and Bas Verhaegh and Tontini, {Gian Eugenio} and Ahmed Madisch and Cord Langner and Andreas M{\"u}nch",

year = "2019",

month = apr,

doi = "10.1016/S2468-1253(19)30048-2",

language = "English",

volume = "4",

pages = "305--314",

journal = "LANCET GASTROENTEROL",

issn = "2468-1253",

publisher = "Elsevier Ltd.",

number = "4",

}

RIS

TY - JOUR

T1 - Microscopic colitis

T2 - pathophysiology and clinical management

AU - Miehlke, Stephan

AU - Verhaegh, Bas

AU - Tontini, Gian Eugenio

AU - Madisch, Ahmed

AU - Langner, Cord

AU - Münch, Andreas

PY - 2019/4

Y1 - 2019/4

N2 - Microscopic colitis is a chronic inflammatory disease of the colon that frequently causes chronic watery diarrhoea that might be accompanied by abdominal pain, nocturnal diarrhoea, urgency, and faecal incontinence. These symptoms lead to poor quality of life and increased health-care costs. Diagnosis relies on histological examination of multiple biopsy samples from the colonic mucosa, which often show no or only few abnormalities on endoscopy. Two major histological subtypes can be distinguished-collagenous colitis and lymphocytic colitis-but incomplete and variant forms with fewer characteristic features have been reported. Here we summarise the latest evidence on epidemiology, pathogenesis, and risk factors, and discuss established and novel therapeutic options for clinical remission. Finally, we propose an updated treatment algorithm. Further prospective studies are needed to clarify the natural history of microscopic colitis, supported by validated criteria for the assessment of disease activity.

AB - Microscopic colitis is a chronic inflammatory disease of the colon that frequently causes chronic watery diarrhoea that might be accompanied by abdominal pain, nocturnal diarrhoea, urgency, and faecal incontinence. These symptoms lead to poor quality of life and increased health-care costs. Diagnosis relies on histological examination of multiple biopsy samples from the colonic mucosa, which often show no or only few abnormalities on endoscopy. Two major histological subtypes can be distinguished-collagenous colitis and lymphocytic colitis-but incomplete and variant forms with fewer characteristic features have been reported. Here we summarise the latest evidence on epidemiology, pathogenesis, and risk factors, and discuss established and novel therapeutic options for clinical remission. Finally, we propose an updated treatment algorithm. Further prospective studies are needed to clarify the natural history of microscopic colitis, supported by validated criteria for the assessment of disease activity.

U2 - 10.1016/S2468-1253(19)30048-2

DO - 10.1016/S2468-1253(19)30048-2

M3 - SCORING: Review article

C2 - 30860066

VL - 4

SP - 305

EP - 314

JO - LANCET GASTROENTEROL

JF - LANCET GASTROENTEROL

SN - 2468-1253

IS - 4

ER -