MicroRNAs: predictors and modifiers of chemo- and radiotherapy in different tumour types

Richard Hummel; Damian J Hussey; Joerg Haier

doi:10.1016/j.ejca.2009.10.027

MicroRNAs: predictors and modifiers of chemo- and radiotherapy in different tumour types

Standard

MicroRNAs: predictors and modifiers of chemo- and radiotherapy in different tumour types. / Hummel, Richard; Hussey, Damian J; Haier, Joerg.

in: EUR J CANCER, Jahrgang 46, Nr. 2, 01.2010, S. 298-311.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Hummel, R, Hussey, DJ & Haier, J 2010, 'MicroRNAs: predictors and modifiers of chemo- and radiotherapy in different tumour types', EUR J CANCER, Jg. 46, Nr. 2, S. 298-311. https://doi.org/10.1016/j.ejca.2009.10.027

APA

Hummel, R., Hussey, D. J., & Haier, J. (2010). MicroRNAs: predictors and modifiers of chemo- and radiotherapy in different tumour types. EUR J CANCER, 46(2), 298-311. https://doi.org/10.1016/j.ejca.2009.10.027

Vancouver

Hummel R, Hussey DJ, Haier J. MicroRNAs: predictors and modifiers of chemo- and radiotherapy in different tumour types. EUR J CANCER. 2010 Jan;46(2):298-311. https://doi.org/10.1016/j.ejca.2009.10.027

Bibtex

@article{13ad89c9943f44c795c0b168fe1297a7,

title = "MicroRNAs: predictors and modifiers of chemo- and radiotherapy in different tumour types",

abstract = "MicroRNAs (miRNAs) represent a class of naturally occurring small non-coding RNA molecules. They regulate gene expression at the post-transcriptional level and control thereby cellular mechanisms including developmental transitions, organ morphology, apoptosis and cell proliferation. As might be expected from molecules with these roles, miRNAs are involved in cancer development, and deregulation of several miRNAs has been found in various cancer types. Some miRNAs modulate expression of known oncogenes or tumour suppressor genes whereas others function as so called onco-miRs or tumour-suppressor-miRs. Recently, miRNAs have been studied as potential diagnostic or therapeutic targets in cancer treatment. There is increasing interest in an association between miRNA expression in tumours and chemo- and radiosensitivity, both with regards to predicting or modulating sensitivity. And indeed, different miRNAs have been found to predict sensitivity to anticancer treatment: miR-30c, miR-130a and miR-335 are downregulated in various chemoresistant cell lines, hsa-Let-7g and hsa-miR-181b are strongly associated with response to 5-fluorouracil-based antimetabolite S-1. In addition, several miRNAs were shown to influence sensitivity to chemo- or radiotherapy: miRNAs of the Let-7 family induced radiosensitivity in vitro/in vivo, inhibition of miR-21 and miR-200b increased sensitivity to gemcitabine in cholangiocarcinoma cell lines, and restoration of miR-34 in p53-deficient human gastric cancer cells induced chemosensitisation. This article summarises the current literature describing the impact of miRNAs on prediction and modification of anticancer treatment including the possible intracellular pathways involved in these processes.",

keywords = "Apoptosis, Biomarkers, Tumor, Down-Regulation, Drug Resistance, Neoplasm, Genes, Tumor Suppressor, Genetic Therapy, Humans, MicroRNAs, Neoplasms, Oncogenes, RNA, Neoplasm, Treatment Outcome, Up-Regulation",

author = "Richard Hummel and Hussey, {Damian J} and Joerg Haier",

year = "2010",

month = jan,

doi = "10.1016/j.ejca.2009.10.027",

language = "English",

volume = "46",

pages = "298--311",

journal = "EUR J CANCER",

issn = "0959-8049",

publisher = "Elsevier Limited",

number = "2",

}

RIS

TY - JOUR

T1 - MicroRNAs: predictors and modifiers of chemo- and radiotherapy in different tumour types

AU - Hummel, Richard

AU - Hussey, Damian J

AU - Haier, Joerg

PY - 2010/1

Y1 - 2010/1

N2 - MicroRNAs (miRNAs) represent a class of naturally occurring small non-coding RNA molecules. They regulate gene expression at the post-transcriptional level and control thereby cellular mechanisms including developmental transitions, organ morphology, apoptosis and cell proliferation. As might be expected from molecules with these roles, miRNAs are involved in cancer development, and deregulation of several miRNAs has been found in various cancer types. Some miRNAs modulate expression of known oncogenes or tumour suppressor genes whereas others function as so called onco-miRs or tumour-suppressor-miRs. Recently, miRNAs have been studied as potential diagnostic or therapeutic targets in cancer treatment. There is increasing interest in an association between miRNA expression in tumours and chemo- and radiosensitivity, both with regards to predicting or modulating sensitivity. And indeed, different miRNAs have been found to predict sensitivity to anticancer treatment: miR-30c, miR-130a and miR-335 are downregulated in various chemoresistant cell lines, hsa-Let-7g and hsa-miR-181b are strongly associated with response to 5-fluorouracil-based antimetabolite S-1. In addition, several miRNAs were shown to influence sensitivity to chemo- or radiotherapy: miRNAs of the Let-7 family induced radiosensitivity in vitro/in vivo, inhibition of miR-21 and miR-200b increased sensitivity to gemcitabine in cholangiocarcinoma cell lines, and restoration of miR-34 in p53-deficient human gastric cancer cells induced chemosensitisation. This article summarises the current literature describing the impact of miRNAs on prediction and modification of anticancer treatment including the possible intracellular pathways involved in these processes.

AB - MicroRNAs (miRNAs) represent a class of naturally occurring small non-coding RNA molecules. They regulate gene expression at the post-transcriptional level and control thereby cellular mechanisms including developmental transitions, organ morphology, apoptosis and cell proliferation. As might be expected from molecules with these roles, miRNAs are involved in cancer development, and deregulation of several miRNAs has been found in various cancer types. Some miRNAs modulate expression of known oncogenes or tumour suppressor genes whereas others function as so called onco-miRs or tumour-suppressor-miRs. Recently, miRNAs have been studied as potential diagnostic or therapeutic targets in cancer treatment. There is increasing interest in an association between miRNA expression in tumours and chemo- and radiosensitivity, both with regards to predicting or modulating sensitivity. And indeed, different miRNAs have been found to predict sensitivity to anticancer treatment: miR-30c, miR-130a and miR-335 are downregulated in various chemoresistant cell lines, hsa-Let-7g and hsa-miR-181b are strongly associated with response to 5-fluorouracil-based antimetabolite S-1. In addition, several miRNAs were shown to influence sensitivity to chemo- or radiotherapy: miRNAs of the Let-7 family induced radiosensitivity in vitro/in vivo, inhibition of miR-21 and miR-200b increased sensitivity to gemcitabine in cholangiocarcinoma cell lines, and restoration of miR-34 in p53-deficient human gastric cancer cells induced chemosensitisation. This article summarises the current literature describing the impact of miRNAs on prediction and modification of anticancer treatment including the possible intracellular pathways involved in these processes.

KW - Apoptosis

KW - Biomarkers, Tumor

KW - Down-Regulation

KW - Drug Resistance, Neoplasm

KW - Genes, Tumor Suppressor

KW - Genetic Therapy

KW - Humans

KW - MicroRNAs

KW - Neoplasms

KW - Oncogenes

KW - RNA, Neoplasm

KW - Treatment Outcome

KW - Up-Regulation

U2 - 10.1016/j.ejca.2009.10.027

DO - 10.1016/j.ejca.2009.10.027

M3 - SCORING: Journal article

C2 - 19948396

VL - 46

SP - 298

EP - 311

JO - EUR J CANCER

JF - EUR J CANCER

SN - 0959-8049

IS - 2

ER -