MicroRNA in Prostate, Bladder, and Kidney Cancer: A Systematic Review.
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MicroRNA in Prostate, Bladder, and Kidney Cancer: A Systematic Review. / Catto, James W F; Alcaraz, Antonio; Bjartell, Anders S; Ralph, De Vere White; Evans, Christopher P; Fussel, Susanne; Hamdy, Freddie C; Kallioniemi, Olli; Mengual, Lourdes; Schlomm, Thorsten; Visakorpi, Tapio.
in: EUR UROL, Jahrgang 59, Nr. 5, 5, 2011, S. 671-681.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - MicroRNA in Prostate, Bladder, and Kidney Cancer: A Systematic Review.
AU - Catto, James W F
AU - Alcaraz, Antonio
AU - Bjartell, Anders S
AU - Ralph, De Vere White
AU - Evans, Christopher P
AU - Fussel, Susanne
AU - Hamdy, Freddie C
AU - Kallioniemi, Olli
AU - Mengual, Lourdes
AU - Schlomm, Thorsten
AU - Visakorpi, Tapio
PY - 2011
Y1 - 2011
N2 - CONTEXT: MicroRNAs (miRNA) are noncoding RNAs that post-transcriptionally regulate gene expression. Their altered expression and function have been observed in most urologic cancers. MiRNAs represent potential disease biomarkers and novel therapeutic targets. OBJECTIVE: To review and evaluate the evidence implicating miRNAs in the pathogenesis of prostate cancer (PCa), bladder cancer (BCa), and renal cancer. EVIDENCE ACQUISITION: A systematic review was performed using PubMed and Embase to search for reports using strings for microRNA, non-coding RNA, cancer, prostate, bladder, and renal cancer. Identified manuscripts were retrieved and references searched. Selected studies were required to concentrate on the role of miRNA in these urologic cancers. EVIDENCE SYNTHESIS: We reviewed articles that focus on this topic. More than 40 miRNAs have been implicated in urologic cancer and many target common carcinogenic pathways. In particular, apoptosis avoidance, cell proliferation, epithelial-to-mesenchymal transition, angiogenic signalling, and the generation of androgen independence are targeted or facilitated by more than one miRNA. Little work has been done to evaluate the translational applications for this knowledge to date. Novel therapeutic strategies have been developed and are under investigation to selectively modulate miRNAs; such work would potentially enable personalised tumour therapy. CONCLUSIONS: MiRNAs appear to be important modulators of urologic cancer. Their expression is frequently altered in these tumours, and many are functionally implicated in their pathogenesis. They require evaluation to determine the translational role and therapeutic potential for this knowledge.
AB - CONTEXT: MicroRNAs (miRNA) are noncoding RNAs that post-transcriptionally regulate gene expression. Their altered expression and function have been observed in most urologic cancers. MiRNAs represent potential disease biomarkers and novel therapeutic targets. OBJECTIVE: To review and evaluate the evidence implicating miRNAs in the pathogenesis of prostate cancer (PCa), bladder cancer (BCa), and renal cancer. EVIDENCE ACQUISITION: A systematic review was performed using PubMed and Embase to search for reports using strings for microRNA, non-coding RNA, cancer, prostate, bladder, and renal cancer. Identified manuscripts were retrieved and references searched. Selected studies were required to concentrate on the role of miRNA in these urologic cancers. EVIDENCE SYNTHESIS: We reviewed articles that focus on this topic. More than 40 miRNAs have been implicated in urologic cancer and many target common carcinogenic pathways. In particular, apoptosis avoidance, cell proliferation, epithelial-to-mesenchymal transition, angiogenic signalling, and the generation of androgen independence are targeted or facilitated by more than one miRNA. Little work has been done to evaluate the translational applications for this knowledge to date. Novel therapeutic strategies have been developed and are under investigation to selectively modulate miRNAs; such work would potentially enable personalised tumour therapy. CONCLUSIONS: MiRNAs appear to be important modulators of urologic cancer. Their expression is frequently altered in these tumours, and many are functionally implicated in their pathogenesis. They require evaluation to determine the translational role and therapeutic potential for this knowledge.
M3 - SCORING: Zeitschriftenaufsatz
VL - 59
SP - 671
EP - 681
JO - EUR UROL
JF - EUR UROL
SN - 0302-2838
IS - 5
M1 - 5
ER -