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Micrometastatic spread in breast cancer: detection, molecular characterization and clinical relevance.

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Micrometastatic spread in breast cancer: detection, molecular characterization and clinical relevance. / Fehm, Tanja; Müller, Volkmar; Alix-Panabières, Catherine; Pantel, Klaus.

in: BREAST CANCER RES, Jahrgang 10, Nr. 1, 1, 2008, S. 1.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Fehm, T, Müller, V, Alix-Panabières, C & Pantel, K 2008, 'Micrometastatic spread in breast cancer: detection, molecular characterization and clinical relevance.', BREAST CANCER RES, Jg. 10, Nr. 1, 1, S. 1. https://doi.org/10.1186/bcr1869

APA

Fehm, T., Müller, V., Alix-Panabières, C., & Pantel, K. (2008). Micrometastatic spread in breast cancer: detection, molecular characterization and clinical relevance. BREAST CANCER RES, 10(1), 1. [1]. https://doi.org/10.1186/bcr1869

Vancouver

Fehm T, Müller V, Alix-Panabières C, Pantel K. Micrometastatic spread in breast cancer: detection, molecular characterization and clinical relevance. BREAST CANCER RES. 2008;10(1):1. 1. https://doi.org/10.1186/bcr1869

Bibtex

@article{673209d262764d4c8863cb064733eb8e,
title = "Micrometastatic spread in breast cancer: detection, molecular characterization and clinical relevance.",
abstract = "Immunocytochemical or molecular assays allow the detection of single disseminated tumor cells (DTCs) in the bone marrow (BM) or the peripheral blood in 10% to 60% of breast cancer patients without signs of metastasis. Results from recently reported studies suggest that circulating tumor cell (CTC) levels may serve as a prognostic marker and be used for early assessment of therapeutic response in patients with metastatic breast cancer. In early stage breast cancer, however, the impact of CTCs is less well established than that of DTCs in BM, where several clinical studies demonstrated that such cells are an independent prognostic factor at primary diagnosis. The characterization of DTCs/CTCs has already shed new light on the complex process underlying early tumor cell dissemination and metastatic progression in cancer patients. Characterization of DTCs should help to identify novel targets for biological therapies aimed to prevent metastatic relapse. In addition, understanding tumor 'dormancy' and identifying metastatic stem cells might result in the development of new therapeutic concepts.",
author = "Tanja Fehm and Volkmar M{\"u}ller and Catherine Alix-Panabi{\`e}res and Klaus Pantel",
year = "2008",
doi = "10.1186/bcr1869",
language = "Deutsch",
volume = "10",
pages = "1",
journal = "BREAST CANCER RES",
issn = "1465-5411",
publisher = "BioMed Central Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - Micrometastatic spread in breast cancer: detection, molecular characterization and clinical relevance.

AU - Fehm, Tanja

AU - Müller, Volkmar

AU - Alix-Panabières, Catherine

AU - Pantel, Klaus

PY - 2008

Y1 - 2008

N2 - Immunocytochemical or molecular assays allow the detection of single disseminated tumor cells (DTCs) in the bone marrow (BM) or the peripheral blood in 10% to 60% of breast cancer patients without signs of metastasis. Results from recently reported studies suggest that circulating tumor cell (CTC) levels may serve as a prognostic marker and be used for early assessment of therapeutic response in patients with metastatic breast cancer. In early stage breast cancer, however, the impact of CTCs is less well established than that of DTCs in BM, where several clinical studies demonstrated that such cells are an independent prognostic factor at primary diagnosis. The characterization of DTCs/CTCs has already shed new light on the complex process underlying early tumor cell dissemination and metastatic progression in cancer patients. Characterization of DTCs should help to identify novel targets for biological therapies aimed to prevent metastatic relapse. In addition, understanding tumor 'dormancy' and identifying metastatic stem cells might result in the development of new therapeutic concepts.

AB - Immunocytochemical or molecular assays allow the detection of single disseminated tumor cells (DTCs) in the bone marrow (BM) or the peripheral blood in 10% to 60% of breast cancer patients without signs of metastasis. Results from recently reported studies suggest that circulating tumor cell (CTC) levels may serve as a prognostic marker and be used for early assessment of therapeutic response in patients with metastatic breast cancer. In early stage breast cancer, however, the impact of CTCs is less well established than that of DTCs in BM, where several clinical studies demonstrated that such cells are an independent prognostic factor at primary diagnosis. The characterization of DTCs/CTCs has already shed new light on the complex process underlying early tumor cell dissemination and metastatic progression in cancer patients. Characterization of DTCs should help to identify novel targets for biological therapies aimed to prevent metastatic relapse. In addition, understanding tumor 'dormancy' and identifying metastatic stem cells might result in the development of new therapeutic concepts.

U2 - 10.1186/bcr1869

DO - 10.1186/bcr1869

M3 - SCORING: Zeitschriftenaufsatz

VL - 10

SP - 1

JO - BREAST CANCER RES

JF - BREAST CANCER RES

SN - 1465-5411

IS - 1

M1 - 1

ER -