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Microglia regulate hippocampal neurogenesis during chronic neurodegeneration

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Microglia regulate hippocampal neurogenesis during chronic neurodegeneration. / De Lucia, Chiara; Rinchon, Adeline; Olmos-Alonso, Adrian; Riecken, Kristoffer; Fehse, Boris; Boche, Delphine; Perry, V Hugh; Gomez-Nicola, Diego.

in: BRAIN BEHAV IMMUN, Jahrgang 55, 07.2016, S. 179-190.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

De Lucia, C, Rinchon, A, Olmos-Alonso, A, Riecken, K, Fehse, B, Boche, D, Perry, VH & Gomez-Nicola, D 2016, 'Microglia regulate hippocampal neurogenesis during chronic neurodegeneration', BRAIN BEHAV IMMUN, Jg. 55, S. 179-190. https://doi.org/10.1016/j.bbi.2015.11.001

APA

De Lucia, C., Rinchon, A., Olmos-Alonso, A., Riecken, K., Fehse, B., Boche, D., Perry, V. H., & Gomez-Nicola, D. (2016). Microglia regulate hippocampal neurogenesis during chronic neurodegeneration. BRAIN BEHAV IMMUN, 55, 179-190. https://doi.org/10.1016/j.bbi.2015.11.001

Vancouver

De Lucia C, Rinchon A, Olmos-Alonso A, Riecken K, Fehse B, Boche D et al. Microglia regulate hippocampal neurogenesis during chronic neurodegeneration. BRAIN BEHAV IMMUN. 2016 Jul;55:179-190. https://doi.org/10.1016/j.bbi.2015.11.001

Bibtex

@article{501cfa13dc0f4d6dbdea768b72e6bdbf,
title = "Microglia regulate hippocampal neurogenesis during chronic neurodegeneration",
abstract = "Neurogenesis is altered in neurodegenerative disorders, partly regulated by inflammatory factors. We have investigated whether microglia, the innate immune brain cells, regulate hippocampal neurogenesis in neurodegeneration. Using the ME7 model of prion disease we applied gain- or loss-of CSF1R function, as means to stimulate or inhibit microglial proliferation, respectively, to dissect the contribution of these cells to neurogenesis. We found that increased hippocampal neurogenesis correlates with the expansion of the microglia population. The selective inhibition of microglial proliferation caused a reduction in neurogenesis and a restoration of normal neuronal differentiation, supporting a pro-neurogenic role for microglia. Using a gene screening strategy, we identified TGFβ as a molecule controlling the microglial pro-neurogenic response in chronic neurodegeneration, supported by loss-of-function mechanistic experiments. By the selective targeting of microglial proliferation we have been able to uncover a pro-neurogenic role for microglia in chronic neurodegeneration, suggesting promising therapeutic targets to normalise the neurogenic niche during neurodegeneration.",
author = "{De Lucia}, Chiara and Adeline Rinchon and Adrian Olmos-Alonso and Kristoffer Riecken and Boris Fehse and Delphine Boche and Perry, {V Hugh} and Diego Gomez-Nicola",
note = "Copyright {\textcopyright} 2015 The Authors. Published by Elsevier Inc. All rights reserved.",
year = "2016",
month = jul,
doi = "10.1016/j.bbi.2015.11.001",
language = "English",
volume = "55",
pages = "179--190",
journal = "BRAIN BEHAV IMMUN",
issn = "0889-1591",
publisher = "Academic Press Inc.",

}

RIS

TY - JOUR

T1 - Microglia regulate hippocampal neurogenesis during chronic neurodegeneration

AU - De Lucia, Chiara

AU - Rinchon, Adeline

AU - Olmos-Alonso, Adrian

AU - Riecken, Kristoffer

AU - Fehse, Boris

AU - Boche, Delphine

AU - Perry, V Hugh

AU - Gomez-Nicola, Diego

N1 - Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

PY - 2016/7

Y1 - 2016/7

N2 - Neurogenesis is altered in neurodegenerative disorders, partly regulated by inflammatory factors. We have investigated whether microglia, the innate immune brain cells, regulate hippocampal neurogenesis in neurodegeneration. Using the ME7 model of prion disease we applied gain- or loss-of CSF1R function, as means to stimulate or inhibit microglial proliferation, respectively, to dissect the contribution of these cells to neurogenesis. We found that increased hippocampal neurogenesis correlates with the expansion of the microglia population. The selective inhibition of microglial proliferation caused a reduction in neurogenesis and a restoration of normal neuronal differentiation, supporting a pro-neurogenic role for microglia. Using a gene screening strategy, we identified TGFβ as a molecule controlling the microglial pro-neurogenic response in chronic neurodegeneration, supported by loss-of-function mechanistic experiments. By the selective targeting of microglial proliferation we have been able to uncover a pro-neurogenic role for microglia in chronic neurodegeneration, suggesting promising therapeutic targets to normalise the neurogenic niche during neurodegeneration.

AB - Neurogenesis is altered in neurodegenerative disorders, partly regulated by inflammatory factors. We have investigated whether microglia, the innate immune brain cells, regulate hippocampal neurogenesis in neurodegeneration. Using the ME7 model of prion disease we applied gain- or loss-of CSF1R function, as means to stimulate or inhibit microglial proliferation, respectively, to dissect the contribution of these cells to neurogenesis. We found that increased hippocampal neurogenesis correlates with the expansion of the microglia population. The selective inhibition of microglial proliferation caused a reduction in neurogenesis and a restoration of normal neuronal differentiation, supporting a pro-neurogenic role for microglia. Using a gene screening strategy, we identified TGFβ as a molecule controlling the microglial pro-neurogenic response in chronic neurodegeneration, supported by loss-of-function mechanistic experiments. By the selective targeting of microglial proliferation we have been able to uncover a pro-neurogenic role for microglia in chronic neurodegeneration, suggesting promising therapeutic targets to normalise the neurogenic niche during neurodegeneration.

U2 - 10.1016/j.bbi.2015.11.001

DO - 10.1016/j.bbi.2015.11.001

M3 - SCORING: Journal article

C2 - 26541819

VL - 55

SP - 179

EP - 190

JO - BRAIN BEHAV IMMUN

JF - BRAIN BEHAV IMMUN

SN - 0889-1591

ER -