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Microbial peptides activate tumour-infiltrating lymphocytes in glioblastoma

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Microbial peptides activate tumour-infiltrating lymphocytes in glioblastoma. / Naghavian, Reza; Faigle, Wolfgang; Oldrati, Pietro; Wang, Jian; Toussaint, Nora C; Qiu, Yuhan; Medici, Gioele; Wacker, Marcel; Freudenmann, Lena K; Bonté, Pierre-Emmanuel; Weller, Michael; Regli, Luca; Amigorena, Sebastian; Rammensee, Hans-Georg; Walz, Juliane S; Brugger, Silvio D; Mohme, Malte; Zhao, Yingdong; Sospedra, Mireia; Neidert, Marian C; Martin, Roland.

in: NATURE, Jahrgang 617, Nr. 7962, 05.2023, S. 807-817.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Naghavian, R, Faigle, W, Oldrati, P, Wang, J, Toussaint, NC, Qiu, Y, Medici, G, Wacker, M, Freudenmann, LK, Bonté, P-E, Weller, M, Regli, L, Amigorena, S, Rammensee, H-G, Walz, JS, Brugger, SD, Mohme, M, Zhao, Y, Sospedra, M, Neidert, MC & Martin, R 2023, 'Microbial peptides activate tumour-infiltrating lymphocytes in glioblastoma', NATURE, Jg. 617, Nr. 7962, S. 807-817. https://doi.org/10.1038/s41586-023-06081-w

APA

Naghavian, R., Faigle, W., Oldrati, P., Wang, J., Toussaint, N. C., Qiu, Y., Medici, G., Wacker, M., Freudenmann, L. K., Bonté, P-E., Weller, M., Regli, L., Amigorena, S., Rammensee, H-G., Walz, J. S., Brugger, S. D., Mohme, M., Zhao, Y., Sospedra, M., ... Martin, R. (2023). Microbial peptides activate tumour-infiltrating lymphocytes in glioblastoma. NATURE, 617(7962), 807-817. https://doi.org/10.1038/s41586-023-06081-w

Vancouver

Naghavian R, Faigle W, Oldrati P, Wang J, Toussaint NC, Qiu Y et al. Microbial peptides activate tumour-infiltrating lymphocytes in glioblastoma. NATURE. 2023 Mai;617(7962):807-817. https://doi.org/10.1038/s41586-023-06081-w

Bibtex

@article{165071ea42364d9994f300ecccdc01ac,
title = "Microbial peptides activate tumour-infiltrating lymphocytes in glioblastoma",
abstract = "Microbial organisms have key roles in numerous physiological processes in the human body and have recently been shown to modify the response to immune checkpoint inhibitors1,2. Here we aim to address the role of microbial organisms and their potential role in immune reactivity against glioblastoma. We demonstrate that HLA molecules of both glioblastoma tissues and tumour cell lines present bacteria-specific peptides. This finding prompted us to examine whether tumour-infiltrating lymphocytes (TILs) recognize tumour-derived bacterial peptides. Bacterial peptides eluted from HLA class II molecules are recognized by TILs, albeit very weakly. Using an unbiased antigen discovery approach to probe the specificity of a TIL CD4+ T cell clone, we show that it recognizes a broad spectrum of peptides from pathogenic bacteria, commensal gut microbiota and also glioblastoma-related tumour antigens. These peptides were also strongly stimulatory for bulk TILs and peripheral blood memory cells, which then respond to tumour-derived target peptides. Our data hint at how bacterial pathogens and bacterial gut microbiota can be involved in specific immune recognition of tumour antigens. The unbiased identification of microbial target antigens for TILs holds promise for future personalized tumour vaccination approaches.",
author = "Reza Naghavian and Wolfgang Faigle and Pietro Oldrati and Jian Wang and Toussaint, {Nora C} and Yuhan Qiu and Gioele Medici and Marcel Wacker and Freudenmann, {Lena K} and Pierre-Emmanuel Bont{\'e} and Michael Weller and Luca Regli and Sebastian Amigorena and Hans-Georg Rammensee and Walz, {Juliane S} and Brugger, {Silvio D} and Malte Mohme and Yingdong Zhao and Mireia Sospedra and Neidert, {Marian C} and Roland Martin",
note = "{\textcopyright} 2023. The Author(s).",
year = "2023",
month = may,
doi = "10.1038/s41586-023-06081-w",
language = "English",
volume = "617",
pages = "807--817",
journal = "NATURE",
issn = "0028-0836",
publisher = "NATURE PUBLISHING GROUP",
number = "7962",

}

RIS

TY - JOUR

T1 - Microbial peptides activate tumour-infiltrating lymphocytes in glioblastoma

AU - Naghavian, Reza

AU - Faigle, Wolfgang

AU - Oldrati, Pietro

AU - Wang, Jian

AU - Toussaint, Nora C

AU - Qiu, Yuhan

AU - Medici, Gioele

AU - Wacker, Marcel

AU - Freudenmann, Lena K

AU - Bonté, Pierre-Emmanuel

AU - Weller, Michael

AU - Regli, Luca

AU - Amigorena, Sebastian

AU - Rammensee, Hans-Georg

AU - Walz, Juliane S

AU - Brugger, Silvio D

AU - Mohme, Malte

AU - Zhao, Yingdong

AU - Sospedra, Mireia

AU - Neidert, Marian C

AU - Martin, Roland

N1 - © 2023. The Author(s).

PY - 2023/5

Y1 - 2023/5

N2 - Microbial organisms have key roles in numerous physiological processes in the human body and have recently been shown to modify the response to immune checkpoint inhibitors1,2. Here we aim to address the role of microbial organisms and their potential role in immune reactivity against glioblastoma. We demonstrate that HLA molecules of both glioblastoma tissues and tumour cell lines present bacteria-specific peptides. This finding prompted us to examine whether tumour-infiltrating lymphocytes (TILs) recognize tumour-derived bacterial peptides. Bacterial peptides eluted from HLA class II molecules are recognized by TILs, albeit very weakly. Using an unbiased antigen discovery approach to probe the specificity of a TIL CD4+ T cell clone, we show that it recognizes a broad spectrum of peptides from pathogenic bacteria, commensal gut microbiota and also glioblastoma-related tumour antigens. These peptides were also strongly stimulatory for bulk TILs and peripheral blood memory cells, which then respond to tumour-derived target peptides. Our data hint at how bacterial pathogens and bacterial gut microbiota can be involved in specific immune recognition of tumour antigens. The unbiased identification of microbial target antigens for TILs holds promise for future personalized tumour vaccination approaches.

AB - Microbial organisms have key roles in numerous physiological processes in the human body and have recently been shown to modify the response to immune checkpoint inhibitors1,2. Here we aim to address the role of microbial organisms and their potential role in immune reactivity against glioblastoma. We demonstrate that HLA molecules of both glioblastoma tissues and tumour cell lines present bacteria-specific peptides. This finding prompted us to examine whether tumour-infiltrating lymphocytes (TILs) recognize tumour-derived bacterial peptides. Bacterial peptides eluted from HLA class II molecules are recognized by TILs, albeit very weakly. Using an unbiased antigen discovery approach to probe the specificity of a TIL CD4+ T cell clone, we show that it recognizes a broad spectrum of peptides from pathogenic bacteria, commensal gut microbiota and also glioblastoma-related tumour antigens. These peptides were also strongly stimulatory for bulk TILs and peripheral blood memory cells, which then respond to tumour-derived target peptides. Our data hint at how bacterial pathogens and bacterial gut microbiota can be involved in specific immune recognition of tumour antigens. The unbiased identification of microbial target antigens for TILs holds promise for future personalized tumour vaccination approaches.

U2 - 10.1038/s41586-023-06081-w

DO - 10.1038/s41586-023-06081-w

M3 - SCORING: Journal article

C2 - 37198490

VL - 617

SP - 807

EP - 817

JO - NATURE

JF - NATURE

SN - 0028-0836

IS - 7962

ER -