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Microarray analysis reveals influence of the sesquiterpene lactone parthenolide on gene transcription profiles in human epithelial cells

Standard

Microarray analysis reveals influence of the sesquiterpene lactone parthenolide on gene transcription profiles in human epithelial cells. / Lindenmeyer, M T; Kern, C; Sparna, T; Donauer, J; Wilpert, J; Schwager, J; Porath, D; Kreutz, C; Timmer, J; Merfort, I.

in: LIFE SCI, Jahrgang 80, Nr. 17, 03.04.2007, S. 1608-18.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Lindenmeyer, MT, Kern, C, Sparna, T, Donauer, J, Wilpert, J, Schwager, J, Porath, D, Kreutz, C, Timmer, J & Merfort, I 2007, 'Microarray analysis reveals influence of the sesquiterpene lactone parthenolide on gene transcription profiles in human epithelial cells', LIFE SCI, Jg. 80, Nr. 17, S. 1608-18. https://doi.org/10.1016/j.lfs.2007.01.036

APA

Lindenmeyer, M. T., Kern, C., Sparna, T., Donauer, J., Wilpert, J., Schwager, J., Porath, D., Kreutz, C., Timmer, J., & Merfort, I. (2007). Microarray analysis reveals influence of the sesquiterpene lactone parthenolide on gene transcription profiles in human epithelial cells. LIFE SCI, 80(17), 1608-18. https://doi.org/10.1016/j.lfs.2007.01.036

Vancouver

Lindenmeyer MT, Kern C, Sparna T, Donauer J, Wilpert J, Schwager J et al. Microarray analysis reveals influence of the sesquiterpene lactone parthenolide on gene transcription profiles in human epithelial cells. LIFE SCI. 2007 Apr 3;80(17):1608-18. https://doi.org/10.1016/j.lfs.2007.01.036

Bibtex

@article{2ce967479e4d40bba1f4f76c5a2160ae,
title = "Microarray analysis reveals influence of the sesquiterpene lactone parthenolide on gene transcription profiles in human epithelial cells",
abstract = "Sesquiterpene lactones are known for their anti-inflammatory activity which has been proven in various assays on DNA, mRNA and protein level. Here we report on the change in the gene expression profile in TNF-alpha stimulated human 293 cells after treatment with parthenolide using a cDNA microarray analysis. Twenty-one of 7028 genes were found to be up- and 18 down-regulated. They encode for chemoattractants, immune system proteins, glycoproteins, metabolism, serine proteinases, and transcription factors. Confirmatory analyses were carried out using quantitative real-time RT-PCR (TaqMan). Additional studies with selected genes revealed the concentration-dependent influence of parthenolide on the expression of these genes.",
keywords = "Anti-Inflammatory Agents, Non-Steroidal, Cell Line, Dose-Response Relationship, Drug, Epithelial Cells, Gene Expression Profiling, Gene Expression Regulation, Humans, Oligonucleotide Array Sequence Analysis, RNA, Messenger, Sesquiterpenes, Transcription, Genetic, Tumor Necrosis Factor-alpha, Journal Article, Research Support, Non-U.S. Gov't",
author = "Lindenmeyer, {M T} and C Kern and T Sparna and J Donauer and J Wilpert and J Schwager and D Porath and C Kreutz and J Timmer and I Merfort",
year = "2007",
month = apr,
day = "3",
doi = "10.1016/j.lfs.2007.01.036",
language = "English",
volume = "80",
pages = "1608--18",
journal = "LIFE SCI",
issn = "0024-3205",
publisher = "Elsevier Inc.",
number = "17",

}

RIS

TY - JOUR

T1 - Microarray analysis reveals influence of the sesquiterpene lactone parthenolide on gene transcription profiles in human epithelial cells

AU - Lindenmeyer, M T

AU - Kern, C

AU - Sparna, T

AU - Donauer, J

AU - Wilpert, J

AU - Schwager, J

AU - Porath, D

AU - Kreutz, C

AU - Timmer, J

AU - Merfort, I

PY - 2007/4/3

Y1 - 2007/4/3

N2 - Sesquiterpene lactones are known for their anti-inflammatory activity which has been proven in various assays on DNA, mRNA and protein level. Here we report on the change in the gene expression profile in TNF-alpha stimulated human 293 cells after treatment with parthenolide using a cDNA microarray analysis. Twenty-one of 7028 genes were found to be up- and 18 down-regulated. They encode for chemoattractants, immune system proteins, glycoproteins, metabolism, serine proteinases, and transcription factors. Confirmatory analyses were carried out using quantitative real-time RT-PCR (TaqMan). Additional studies with selected genes revealed the concentration-dependent influence of parthenolide on the expression of these genes.

AB - Sesquiterpene lactones are known for their anti-inflammatory activity which has been proven in various assays on DNA, mRNA and protein level. Here we report on the change in the gene expression profile in TNF-alpha stimulated human 293 cells after treatment with parthenolide using a cDNA microarray analysis. Twenty-one of 7028 genes were found to be up- and 18 down-regulated. They encode for chemoattractants, immune system proteins, glycoproteins, metabolism, serine proteinases, and transcription factors. Confirmatory analyses were carried out using quantitative real-time RT-PCR (TaqMan). Additional studies with selected genes revealed the concentration-dependent influence of parthenolide on the expression of these genes.

KW - Anti-Inflammatory Agents, Non-Steroidal

KW - Cell Line

KW - Dose-Response Relationship, Drug

KW - Epithelial Cells

KW - Gene Expression Profiling

KW - Gene Expression Regulation

KW - Humans

KW - Oligonucleotide Array Sequence Analysis

KW - RNA, Messenger

KW - Sesquiterpenes

KW - Transcription, Genetic

KW - Tumor Necrosis Factor-alpha

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.lfs.2007.01.036

DO - 10.1016/j.lfs.2007.01.036

M3 - SCORING: Journal article

C2 - 17343877

VL - 80

SP - 1608

EP - 1618

JO - LIFE SCI

JF - LIFE SCI

SN - 0024-3205

IS - 17

ER -