Metabolic Turnover Studies to Quantify Energy Uptake by Thermogenic Adipose Tissues of Mice
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Metabolic Turnover Studies to Quantify Energy Uptake by Thermogenic Adipose Tissues of Mice. / Heine, Markus; Corban, Carlotta; Heeren, Joerg.
Brown Adipose Tissue: Methods and Protocols. 1. Aufl. New York, NY : HUMANA PRESS INC, 2022. S. 107-118 (Methods in Molecular Biology; Band 2448).Publikationen: SCORING: Beitrag in Buch/Sammelwerk › SCORING: Beitrag in Sammelwerk › Forschung › Begutachtung
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TY - CHAP
T1 - Metabolic Turnover Studies to Quantify Energy Uptake by Thermogenic Adipose Tissues of Mice
AU - Heine, Markus
AU - Corban, Carlotta
AU - Heeren, Joerg
N1 - © 2022. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2022
Y1 - 2022
N2 - The uptake of glucose, non-esterified fatty acids, and triglycerides into brown adipose tissue is an important determinant of systemic energy metabolism, which can be studied by metabolic turnover studies using radioactive tracers in vivo. Here, we address the uptake of glucose and lipid tracers into metabolically active organs with a focus on thermogenically activated adipose tissues. Uptake by beige and brown adipocytes is highly dependent on conditions such as ambient temperature, but also varies between fasted compared to postprandial states. Accordingly, we provide methodological insights how to quantify glucose and lipid disposal under multiple physiological and environmental conditions.
AB - The uptake of glucose, non-esterified fatty acids, and triglycerides into brown adipose tissue is an important determinant of systemic energy metabolism, which can be studied by metabolic turnover studies using radioactive tracers in vivo. Here, we address the uptake of glucose and lipid tracers into metabolically active organs with a focus on thermogenically activated adipose tissues. Uptake by beige and brown adipocytes is highly dependent on conditions such as ambient temperature, but also varies between fasted compared to postprandial states. Accordingly, we provide methodological insights how to quantify glucose and lipid disposal under multiple physiological and environmental conditions.
KW - Adipocytes, Brown
KW - Adipose Tissue, Brown/metabolism
KW - Adipose Tissue, White/metabolism
KW - Animals
KW - Energy Metabolism
KW - Mice
KW - Thermogenesis
U2 - 10.1007/978-1-0716-2087-8_7
DO - 10.1007/978-1-0716-2087-8_7
M3 - SCORING: Contribution to collected editions/anthologies
C2 - 35167093
SN - 978-1-0716-2086-1
SN - 978-1-0716-2089-2
T3 - Methods in Molecular Biology
SP - 107
EP - 118
BT - Brown Adipose Tissue
PB - HUMANA PRESS INC
CY - New York, NY
ER -