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Metabolic profiling of pregnancy: cross-sectional and longitudinal evidence

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Metabolic profiling of pregnancy: cross-sectional and longitudinal evidence. / Wang, Qin; Würtz, Peter; Auro, Kirsi; Mäkinen, Ville-Petteri; Kangas, Antti J; Soininen, Pasi; Tiainen, Mika; Tynkkynen, Tuulia; Jokelainen, Jari; Santalahti, Kristiina; Salmi, Marko; Blankenberg, Stefan; Zeller, Tanja; Viikari, Jorma; Kähönen, Mika; Lehtimäki, Terho; Salomaa, Veikko; Perola, Markus; Jalkanen, Sirpa; Järvelin, Marjo-Riitta; Raitakari, Olli T; Kettunen, Johannes; Lawlor, Debbie A; Ala-Korpela, Mika.

in: BMC MED, Jahrgang 14, Nr. 1, 13.12.2016, S. 205.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Wang, Q, Würtz, P, Auro, K, Mäkinen, V-P, Kangas, AJ, Soininen, P, Tiainen, M, Tynkkynen, T, Jokelainen, J, Santalahti, K, Salmi, M, Blankenberg, S, Zeller, T, Viikari, J, Kähönen, M, Lehtimäki, T, Salomaa, V, Perola, M, Jalkanen, S, Järvelin, M-R, Raitakari, OT, Kettunen, J, Lawlor, DA & Ala-Korpela, M 2016, 'Metabolic profiling of pregnancy: cross-sectional and longitudinal evidence', BMC MED, Jg. 14, Nr. 1, S. 205. https://doi.org/10.1186/s12916-016-0733-0

APA

Wang, Q., Würtz, P., Auro, K., Mäkinen, V-P., Kangas, A. J., Soininen, P., Tiainen, M., Tynkkynen, T., Jokelainen, J., Santalahti, K., Salmi, M., Blankenberg, S., Zeller, T., Viikari, J., Kähönen, M., Lehtimäki, T., Salomaa, V., Perola, M., Jalkanen, S., ... Ala-Korpela, M. (2016). Metabolic profiling of pregnancy: cross-sectional and longitudinal evidence. BMC MED, 14(1), 205. https://doi.org/10.1186/s12916-016-0733-0

Vancouver

Wang Q, Würtz P, Auro K, Mäkinen V-P, Kangas AJ, Soininen P et al. Metabolic profiling of pregnancy: cross-sectional and longitudinal evidence. BMC MED. 2016 Dez 13;14(1):205. https://doi.org/10.1186/s12916-016-0733-0

Bibtex

@article{67d9af2532214b9abc5473c041d965d6,
title = "Metabolic profiling of pregnancy: cross-sectional and longitudinal evidence",
abstract = "BACKGROUND: Pregnancy triggers well-known alterations in maternal glucose and lipid balance but its overall effects on systemic metabolism remain incompletely understood.METHODS: Detailed molecular profiles (87 metabolic measures and 37 cytokines) were measured for up to 4260 women (24-49 years, 322 pregnant) from three population-based cohorts in Finland. Circulating molecular concentrations in pregnant women were compared to those in non-pregnant women. Metabolic profiles were also reassessed for 583 women 6 years later to uncover the longitudinal metabolic changes in response to change in the pregnancy status.RESULTS: Compared to non-pregnant women, all lipoprotein subclasses and lipids were markedly increased in pregnant women. The most pronounced differences were observed for the intermediate-density, low-density and high-density lipoprotein triglyceride concentrations. Large differences were also seen for many fatty acids and amino acids. Pregnant women also had higher concentrations of low-grade inflammatory marker glycoprotein acetyls, higher concentrations of interleukin-18 and lower concentrations of interleukin-12p70. The changes in metabolic concentrations for women who were not pregnant at baseline but pregnant 6 years later (or vice versa) matched (or were mirror-images of) the cross-sectional association pattern. Cross-sectional results were consistent across the three cohorts and similar longitudinal changes were seen for 653 women in 4-year and 497 women in 10-year follow-up. For multiple metabolic measures, the changes increased in magnitude across the three trimesters.CONCLUSIONS: Pregnancy initiates substantial metabolic and inflammatory changes in the mothers. Comprehensive characterisation of normal pregnancy is important for gaining understanding of the key nutrients for fetal growth and development. These findings also provide a valuable molecular reference in relation to studies of adverse pregnancy outcomes.",
keywords = "Adult, Cross-Sectional Studies, Female, Finland, Humans, Metabolomics/methods, Middle Aged, Pregnancy/metabolism, Young Adult",
author = "Qin Wang and Peter W{\"u}rtz and Kirsi Auro and Ville-Petteri M{\"a}kinen and Kangas, {Antti J} and Pasi Soininen and Mika Tiainen and Tuulia Tynkkynen and Jari Jokelainen and Kristiina Santalahti and Marko Salmi and Stefan Blankenberg and Tanja Zeller and Jorma Viikari and Mika K{\"a}h{\"o}nen and Terho Lehtim{\"a}ki and Veikko Salomaa and Markus Perola and Sirpa Jalkanen and Marjo-Riitta J{\"a}rvelin and Raitakari, {Olli T} and Johannes Kettunen and Lawlor, {Debbie A} and Mika Ala-Korpela",
year = "2016",
month = dec,
day = "13",
doi = "10.1186/s12916-016-0733-0",
language = "English",
volume = "14",
pages = "205",
journal = "BMC MED",
issn = "1741-7015",
publisher = "BioMed Central Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - Metabolic profiling of pregnancy: cross-sectional and longitudinal evidence

AU - Wang, Qin

AU - Würtz, Peter

AU - Auro, Kirsi

AU - Mäkinen, Ville-Petteri

AU - Kangas, Antti J

AU - Soininen, Pasi

AU - Tiainen, Mika

AU - Tynkkynen, Tuulia

AU - Jokelainen, Jari

AU - Santalahti, Kristiina

AU - Salmi, Marko

AU - Blankenberg, Stefan

AU - Zeller, Tanja

AU - Viikari, Jorma

AU - Kähönen, Mika

AU - Lehtimäki, Terho

AU - Salomaa, Veikko

AU - Perola, Markus

AU - Jalkanen, Sirpa

AU - Järvelin, Marjo-Riitta

AU - Raitakari, Olli T

AU - Kettunen, Johannes

AU - Lawlor, Debbie A

AU - Ala-Korpela, Mika

PY - 2016/12/13

Y1 - 2016/12/13

N2 - BACKGROUND: Pregnancy triggers well-known alterations in maternal glucose and lipid balance but its overall effects on systemic metabolism remain incompletely understood.METHODS: Detailed molecular profiles (87 metabolic measures and 37 cytokines) were measured for up to 4260 women (24-49 years, 322 pregnant) from three population-based cohorts in Finland. Circulating molecular concentrations in pregnant women were compared to those in non-pregnant women. Metabolic profiles were also reassessed for 583 women 6 years later to uncover the longitudinal metabolic changes in response to change in the pregnancy status.RESULTS: Compared to non-pregnant women, all lipoprotein subclasses and lipids were markedly increased in pregnant women. The most pronounced differences were observed for the intermediate-density, low-density and high-density lipoprotein triglyceride concentrations. Large differences were also seen for many fatty acids and amino acids. Pregnant women also had higher concentrations of low-grade inflammatory marker glycoprotein acetyls, higher concentrations of interleukin-18 and lower concentrations of interleukin-12p70. The changes in metabolic concentrations for women who were not pregnant at baseline but pregnant 6 years later (or vice versa) matched (or were mirror-images of) the cross-sectional association pattern. Cross-sectional results were consistent across the three cohorts and similar longitudinal changes were seen for 653 women in 4-year and 497 women in 10-year follow-up. For multiple metabolic measures, the changes increased in magnitude across the three trimesters.CONCLUSIONS: Pregnancy initiates substantial metabolic and inflammatory changes in the mothers. Comprehensive characterisation of normal pregnancy is important for gaining understanding of the key nutrients for fetal growth and development. These findings also provide a valuable molecular reference in relation to studies of adverse pregnancy outcomes.

AB - BACKGROUND: Pregnancy triggers well-known alterations in maternal glucose and lipid balance but its overall effects on systemic metabolism remain incompletely understood.METHODS: Detailed molecular profiles (87 metabolic measures and 37 cytokines) were measured for up to 4260 women (24-49 years, 322 pregnant) from three population-based cohorts in Finland. Circulating molecular concentrations in pregnant women were compared to those in non-pregnant women. Metabolic profiles were also reassessed for 583 women 6 years later to uncover the longitudinal metabolic changes in response to change in the pregnancy status.RESULTS: Compared to non-pregnant women, all lipoprotein subclasses and lipids were markedly increased in pregnant women. The most pronounced differences were observed for the intermediate-density, low-density and high-density lipoprotein triglyceride concentrations. Large differences were also seen for many fatty acids and amino acids. Pregnant women also had higher concentrations of low-grade inflammatory marker glycoprotein acetyls, higher concentrations of interleukin-18 and lower concentrations of interleukin-12p70. The changes in metabolic concentrations for women who were not pregnant at baseline but pregnant 6 years later (or vice versa) matched (or were mirror-images of) the cross-sectional association pattern. Cross-sectional results were consistent across the three cohorts and similar longitudinal changes were seen for 653 women in 4-year and 497 women in 10-year follow-up. For multiple metabolic measures, the changes increased in magnitude across the three trimesters.CONCLUSIONS: Pregnancy initiates substantial metabolic and inflammatory changes in the mothers. Comprehensive characterisation of normal pregnancy is important for gaining understanding of the key nutrients for fetal growth and development. These findings also provide a valuable molecular reference in relation to studies of adverse pregnancy outcomes.

KW - Adult

KW - Cross-Sectional Studies

KW - Female

KW - Finland

KW - Humans

KW - Metabolomics/methods

KW - Middle Aged

KW - Pregnancy/metabolism

KW - Young Adult

U2 - 10.1186/s12916-016-0733-0

DO - 10.1186/s12916-016-0733-0

M3 - SCORING: Journal article

C2 - 27955712

VL - 14

SP - 205

JO - BMC MED

JF - BMC MED

SN - 1741-7015

IS - 1

ER -