Metabolic profiling of alcohol consumption in 9778 young adults
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Metabolic profiling of alcohol consumption in 9778 young adults. / Würtz, Peter; Cook, Sarah; Wang, Qin; Tiainen, Mika; Tynkkynen, Tuulia; Kangas, Antti J; Soininen, Pasi; Laitinen, Jaana; Viikari, Jorma; Kähönen, Mika; Lehtimäki, Terho; Perola, Markus; Blankenberg, Stefan; Zeller, Tanja; Männistö, Satu; Salomaa, Veikko; Järvelin, Marjo-Riitta; Raitakari, Olli T; Ala-Korpela, Mika; Leon, David A.
in: INT J EPIDEMIOL, Jahrgang 45, Nr. 5, 10.2016, S. 1493-1506.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Metabolic profiling of alcohol consumption in 9778 young adults
AU - Würtz, Peter
AU - Cook, Sarah
AU - Wang, Qin
AU - Tiainen, Mika
AU - Tynkkynen, Tuulia
AU - Kangas, Antti J
AU - Soininen, Pasi
AU - Laitinen, Jaana
AU - Viikari, Jorma
AU - Kähönen, Mika
AU - Lehtimäki, Terho
AU - Perola, Markus
AU - Blankenberg, Stefan
AU - Zeller, Tanja
AU - Männistö, Satu
AU - Salomaa, Veikko
AU - Järvelin, Marjo-Riitta
AU - Raitakari, Olli T
AU - Ala-Korpela, Mika
AU - Leon, David A
N1 - © The Author 2016; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association.
PY - 2016/10
Y1 - 2016/10
N2 - BACKGROUND: High alcohol consumption is a major cause of morbidity, yet alcohol is associated with both favourable and adverse effects on cardiometabolic risk markers. We aimed to characterize the associations of usual alcohol consumption with a comprehensive systemic metabolite profile in young adults.METHODS: Cross-sectional associations of alcohol intake with 86 metabolic measures were assessed for 9778 individuals from three population-based cohorts from Finland (age 24-45 years, 52% women). Metabolic changes associated with change in alcohol intake during 6-year follow-up were further examined for 1466 individuals. Alcohol intake was assessed by questionnaires. Circulating lipids, fatty acids and metabolites were quantified by high-throughput nuclear magnetic resonance metabolomics and biochemical assays.RESULTS: Increased alcohol intake was associated with cardiometabolic risk markers across multiple metabolic pathways, including higher lipid concentrations in HDL subclasses and smaller LDL particle size, increased proportions of monounsaturated fatty acids and decreased proportion of omega-6 fatty acids, lower concentrations of glutamine and citrate (P < 0.001 for 56 metabolic measures). Many metabolic biomarkers displayed U-shaped associations with alcohol consumption. Results were coherent for men and women, consistent across the three cohorts and similar if adjusting for body mass index, smoking and physical activity. The metabolic changes accompanying change in alcohol intake during follow-up resembled the cross-sectional association pattern (R2 = 0.83, slope = 0.72 ± 0.04).CONCLUSIONS: Alcohol consumption is associated with a complex metabolic signature, including aberrations in multiple biomarkers for elevated cardiometabolic risk. The metabolic signature tracks with long-term changes in alcohol consumption. These results elucidate the double-edged effects of alcohol on cardiovascular risk.
AB - BACKGROUND: High alcohol consumption is a major cause of morbidity, yet alcohol is associated with both favourable and adverse effects on cardiometabolic risk markers. We aimed to characterize the associations of usual alcohol consumption with a comprehensive systemic metabolite profile in young adults.METHODS: Cross-sectional associations of alcohol intake with 86 metabolic measures were assessed for 9778 individuals from three population-based cohorts from Finland (age 24-45 years, 52% women). Metabolic changes associated with change in alcohol intake during 6-year follow-up were further examined for 1466 individuals. Alcohol intake was assessed by questionnaires. Circulating lipids, fatty acids and metabolites were quantified by high-throughput nuclear magnetic resonance metabolomics and biochemical assays.RESULTS: Increased alcohol intake was associated with cardiometabolic risk markers across multiple metabolic pathways, including higher lipid concentrations in HDL subclasses and smaller LDL particle size, increased proportions of monounsaturated fatty acids and decreased proportion of omega-6 fatty acids, lower concentrations of glutamine and citrate (P < 0.001 for 56 metabolic measures). Many metabolic biomarkers displayed U-shaped associations with alcohol consumption. Results were coherent for men and women, consistent across the three cohorts and similar if adjusting for body mass index, smoking and physical activity. The metabolic changes accompanying change in alcohol intake during follow-up resembled the cross-sectional association pattern (R2 = 0.83, slope = 0.72 ± 0.04).CONCLUSIONS: Alcohol consumption is associated with a complex metabolic signature, including aberrations in multiple biomarkers for elevated cardiometabolic risk. The metabolic signature tracks with long-term changes in alcohol consumption. These results elucidate the double-edged effects of alcohol on cardiovascular risk.
KW - Adult
KW - Alcohol Drinking/blood
KW - Amino Acids/blood
KW - Biomarkers/blood
KW - Body Mass Index
KW - Cross-Sectional Studies
KW - Fatty Acids/blood
KW - Female
KW - Finland
KW - Humans
KW - Linear Models
KW - Lipoproteins/blood
KW - Male
KW - Metabolome
KW - Metabolomics
KW - Risk Factors
U2 - 10.1093/ije/dyw175
DO - 10.1093/ije/dyw175
M3 - SCORING: Journal article
C2 - 27494945
VL - 45
SP - 1493
EP - 1506
JO - INT J EPIDEMIOL
JF - INT J EPIDEMIOL
SN - 0300-5771
IS - 5
ER -
