PortalPublikationenMeta-analysis of five genome-wide association studies identi...

Meta-analysis of five genome-wide association studies identifies multiple new loci associated with testicular germ cell tumor

Standard

Meta-analysis of five genome-wide association studies identifies multiple new loci associated with testicular germ cell tumor. / Wang, Zhaoming; McGlynn, Katherine A; Rajpert-De Meyts, Ewa; Bishop, D Timothy; Chung, Charles C; Dalgaard, Marlene D; Greene, Mark H; Gupta, Ramneek; Grotmol, Tom; Haugen, Trine B; Karlsson, Robert; Litchfield, Kevin; Mitra, Nandita; Nielsen, Kasper; Pyle, Louise C; Schwartz, Stephen M; Thorsson, Vésteinn; Vardhanabhuti, Saran; Wiklund, Fredrik; Turnbull, Clare; Chanock, Stephen J; Kanetsky, Peter A; Nathanson, Katherine L; Testicular Cancer Consortium.

in: NAT GENET, Jahrgang 49, Nr. 7, 07.2017, S. 1141-1147.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Wang, Z, McGlynn, KA, Rajpert-De Meyts, E, Bishop, DT, Chung, CC, Dalgaard, MD, Greene, MH, Gupta, R, Grotmol, T, Haugen, TB, Karlsson, R, Litchfield, K, Mitra, N, Nielsen, K, Pyle, LC, Schwartz, SM, Thorsson, V, Vardhanabhuti, S, Wiklund, F, Turnbull, C, Chanock, SJ, Kanetsky, PA, Nathanson, KL & Testicular Cancer Consortium 2017, 'Meta-analysis of five genome-wide association studies identifies multiple new loci associated with testicular germ cell tumor', NAT GENET, Jg. 49, Nr. 7, S. 1141-1147. https://doi.org/10.1038/ng.3879

APA

Wang, Z., McGlynn, K. A., Rajpert-De Meyts, E., Bishop, D. T., Chung, C. C., Dalgaard, M. D., Greene, M. H., Gupta, R., Grotmol, T., Haugen, T. B., Karlsson, R., Litchfield, K., Mitra, N., Nielsen, K., Pyle, L. C., Schwartz, S. M., Thorsson, V., Vardhanabhuti, S., Wiklund, F., ... Testicular Cancer Consortium (2017). Meta-analysis of five genome-wide association studies identifies multiple new loci associated with testicular germ cell tumor. NAT GENET, 49(7), 1141-1147. https://doi.org/10.1038/ng.3879

Vancouver

Wang Z, McGlynn KA, Rajpert-De Meyts E, Bishop DT, Chung CC, Dalgaard MD et al. Meta-analysis of five genome-wide association studies identifies multiple new loci associated with testicular germ cell tumor. NAT GENET. 2017 Jul;49(7):1141-1147. https://doi.org/10.1038/ng.3879

Bibtex

@article{3544923932714317bdaa11018e2e657c,
title = "Meta-analysis of five genome-wide association studies identifies multiple new loci associated with testicular germ cell tumor",
abstract = "The international Testicular Cancer Consortium (TECAC) combined five published genome-wide association studies of testicular germ cell tumor (TGCT; 3,558 cases and 13,970 controls) to identify new susceptibility loci. We conducted a fixed-effects meta-analysis, including, to our knowledge, the first analysis of the X chromosome. Eight new loci mapping to 2q14.2, 3q26.2, 4q35.2, 7q36.3, 10q26.13, 15q21.3, 15q22.31, and Xq28 achieved genome-wide significance (P < 5 × 10(-8)). Most loci harbor biologically plausible candidate genes. We refined previously reported associations at 9p24.3 and 19p12 by identifying one and three additional independent SNPs, respectively. In aggregate, the 39 independent markers identified to date explain 37% of father-to-son familial risk, 8% of which can be attributed to the 12 new signals reported here. Our findings substantially increase the number of known TGCT susceptibility alleles, move the field closer to a comprehensive understanding of the underlying genetic architecture of TGCT, and provide further clues to the etiology of TGCT.",
keywords = "Adult, Chromosome Mapping, Chromosomes, Human, X, Computational Biology, Computer Simulation, Family Health, Genetic Markers, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Haplotypes, Humans, Male, Neoplasms, Germ Cell and Embryonal, Polymorphism, Single Nucleotide, Risk, Testicular Neoplasms, Young Adult, Journal Article, Meta-Analysis",
author = "Zhaoming Wang and McGlynn, {Katherine A} and {Rajpert-De Meyts}, Ewa and Bishop, {D Timothy} and Chung, {Charles C} and Dalgaard, {Marlene D} and Greene, {Mark H} and Ramneek Gupta and Tom Grotmol and Haugen, {Trine B} and Robert Karlsson and Kevin Litchfield and Nandita Mitra and Kasper Nielsen and Pyle, {Louise C} and Schwartz, {Stephen M} and V{\'e}steinn Thorsson and Saran Vardhanabhuti and Fredrik Wiklund and Clare Turnbull and Chanock, {Stephen J} and Kanetsky, {Peter A} and Nathanson, {Katherine L} and {Testicular Cancer Consortium}",
year = "2017",
month = jul,
doi = "10.1038/ng.3879",
language = "English",
volume = "49",
pages = "1141--1147",
journal = "NAT GENET",
issn = "1061-4036",
publisher = "NATURE PUBLISHING GROUP",
number = "7",

}

RIS

TY - JOUR

T1 - Meta-analysis of five genome-wide association studies identifies multiple new loci associated with testicular germ cell tumor

AU - Wang, Zhaoming

AU - McGlynn, Katherine A

AU - Rajpert-De Meyts, Ewa

AU - Bishop, D Timothy

AU - Chung, Charles C

AU - Dalgaard, Marlene D

AU - Greene, Mark H

AU - Gupta, Ramneek

AU - Grotmol, Tom

AU - Haugen, Trine B

AU - Karlsson, Robert

AU - Litchfield, Kevin

AU - Mitra, Nandita

AU - Nielsen, Kasper

AU - Pyle, Louise C

AU - Schwartz, Stephen M

AU - Thorsson, Vésteinn

AU - Vardhanabhuti, Saran

AU - Wiklund, Fredrik

AU - Turnbull, Clare

AU - Chanock, Stephen J

AU - Kanetsky, Peter A

AU - Nathanson, Katherine L

AU - Testicular Cancer Consortium

PY - 2017/7

Y1 - 2017/7

N2 - The international Testicular Cancer Consortium (TECAC) combined five published genome-wide association studies of testicular germ cell tumor (TGCT; 3,558 cases and 13,970 controls) to identify new susceptibility loci. We conducted a fixed-effects meta-analysis, including, to our knowledge, the first analysis of the X chromosome. Eight new loci mapping to 2q14.2, 3q26.2, 4q35.2, 7q36.3, 10q26.13, 15q21.3, 15q22.31, and Xq28 achieved genome-wide significance (P < 5 × 10(-8)). Most loci harbor biologically plausible candidate genes. We refined previously reported associations at 9p24.3 and 19p12 by identifying one and three additional independent SNPs, respectively. In aggregate, the 39 independent markers identified to date explain 37% of father-to-son familial risk, 8% of which can be attributed to the 12 new signals reported here. Our findings substantially increase the number of known TGCT susceptibility alleles, move the field closer to a comprehensive understanding of the underlying genetic architecture of TGCT, and provide further clues to the etiology of TGCT.

AB - The international Testicular Cancer Consortium (TECAC) combined five published genome-wide association studies of testicular germ cell tumor (TGCT; 3,558 cases and 13,970 controls) to identify new susceptibility loci. We conducted a fixed-effects meta-analysis, including, to our knowledge, the first analysis of the X chromosome. Eight new loci mapping to 2q14.2, 3q26.2, 4q35.2, 7q36.3, 10q26.13, 15q21.3, 15q22.31, and Xq28 achieved genome-wide significance (P < 5 × 10(-8)). Most loci harbor biologically plausible candidate genes. We refined previously reported associations at 9p24.3 and 19p12 by identifying one and three additional independent SNPs, respectively. In aggregate, the 39 independent markers identified to date explain 37% of father-to-son familial risk, 8% of which can be attributed to the 12 new signals reported here. Our findings substantially increase the number of known TGCT susceptibility alleles, move the field closer to a comprehensive understanding of the underlying genetic architecture of TGCT, and provide further clues to the etiology of TGCT.

KW - Adult

KW - Chromosome Mapping

KW - Chromosomes, Human, X

KW - Computational Biology

KW - Computer Simulation

KW - Family Health

KW - Genetic Markers

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - Genotype

KW - Haplotypes

KW - Humans

KW - Male

KW - Neoplasms, Germ Cell and Embryonal

KW - Polymorphism, Single Nucleotide

KW - Risk

KW - Testicular Neoplasms

KW - Young Adult

KW - Journal Article

KW - Meta-Analysis

U2 - 10.1038/ng.3879

DO - 10.1038/ng.3879

M3 - SCORING: Journal article

C2 - 28604732

VL - 49

SP - 1141

EP - 1147

JO - NAT GENET

JF - NAT GENET

SN - 1061-4036

IS - 7

ER -