Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

J C Lambert; C A Ibrahim-Verbaas; D Harold; A C Naj; R Sims; C Bellenguez; A L DeStafano; J C Bis; G W Beecham; B Grenier-Boley; G Russo; T A Thorton-Wells; N Jones; A V Smith; V Chouraki; C Thomas; M A Ikram; D Zelenika; B N Vardarajan; Y Kamatani; C F Lin; A Gerrish; H Schmidt; B Kunkle; M L Dunstan; A Ruiz; M T Bihoreau; S H Choi; C Reitz; F Pasquier; C Cruchaga; D Craig; N Amin; C Berr; O L Lopez; P L De Jager; V Deramecourt; J A Johnston; D Evans; S Lovestone; L Letenneur; F J Morón; D C Rubinsztein; G Eiriksdottir; K Sleegers; A M Goate; N Fiévet; M W Huentelman; M Gill; K Brown; M I Kamboh; L Keller; P Barberger-Gateau; B McGuiness; E B Larson; R Green; A J Myers; C Dufouil; S Todd; D Wallon; S Love; E Rogaeva; J Gallacher; P St George-Hyslop; J Clarimon; A Lleo; A Bayer; D W Tsuang; L Yu; M Tsolaki; P Bossù; G Spalletta; P Proitsi; J Collinge; S Sorbi; F Sanchez-Garcia; N C Fox; J Hardy; M C Deniz Naranjo; P Bosco; R Clarke; C Brayne; D Galimberti; M Mancuso; F Matthews; S Moebus; P Mecocci; M Del Zompo; W Maier; H Hampel; A Pilotto; M Bullido; F Panza; P Caffarra; B Nacmias; J R Gilbert; M Mayhaus; L Lannefelt; H Hakonarson; S Pichler; M M Carrasquillo; M Ingelsson; D Beekly; V Alvarez; F Zou; O Valladares; S G Younkin; E Coto; K L Hamilton-Nelson; W Gu; C Razquin; P Pastor; I Mateo; M J Owen; K M Faber; P V Jonsson; O Combarros; M C O'Donovan; L B Cantwell; H Soininen; D Blacker; S Mead; T H Mosley; D A Bennett; T B Harris; L Fratiglioni; C Holmes; R F de Bruijn; P Passmore; T J Montine; K Bettens; J I Rotter; A Brice; K Morgan; T M Foroud; W A Kukull; D Hannequin; J F Powell; M A Nalls; K Ritchie; K L Lunetta; J S Kauwe; E Boerwinkle; M Riemenschneider; M Boada; M Hiltuenen; E R Martin; R Schmidt; D Rujescu; L S Wang; J F Dartigues; R Mayeux; C Tzourio; A Hofman; M M Nöthen; C Graff; B M Psaty; L Jones; J L Haines; P A Holmans; M Lathrop; M A Pericak-Vance; L J Launer; L A Farrer; C M van Duijn; C Van Broeckhoven; V Moskvina; S Seshadri; J Williams; G D Schellenberg; P Amouyel; European Alzheimer's Disease Initiative (EADI)

doi:10.1038/ng.2802

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

Standard

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. / Lambert, J C; Ibrahim-Verbaas, C A; Harold, D; Naj, A C; Sims, R; Bellenguez, C; DeStafano, A L; Bis, J C; Beecham, G W; Grenier-Boley, B; Russo, G; Thorton-Wells, T A; Jones, N; Smith, A V; Chouraki, V; Thomas, C; Ikram, M A; Zelenika, D; Vardarajan, B N; Kamatani, Y; Lin, C F; Gerrish, A; Schmidt, H; Kunkle, B; Dunstan, M L; Ruiz, A; Bihoreau, M T; Choi, S H; Reitz, C; Pasquier, F; Cruchaga, C; Craig, D; Amin, N; Berr, C; Lopez, O L; De Jager, P L; Deramecourt, V; Johnston, J A; Evans, D; Lovestone, S; Letenneur, L; Morón, F J; Rubinsztein, D C; Eiriksdottir, G; Sleegers, K; Goate, A M; Fiévet, N; Huentelman, M W; Gill, M; Brown, K; Kamboh, M I; Keller, L; Barberger-Gateau, P; McGuiness, B; Larson, E B; Green, R; Myers, A J; Dufouil, C; Todd, S; Wallon, D; Love, S; Rogaeva, E; Gallacher, J; St George-Hyslop, P; Clarimon, J; Lleo, A; Bayer, A; Tsuang, D W; Yu, L; Tsolaki, M; Bossù, P; Spalletta, G; Proitsi, P; Collinge, J; Sorbi, S; Sanchez-Garcia, F; Fox, N C; Hardy, J; Deniz Naranjo, M C; Bosco, P; Clarke, R; Brayne, C; Galimberti, D; Mancuso, M; Matthews, F; Moebus, S; Mecocci, P; Del Zompo, M; Maier, W; Hampel, H; Pilotto, A; Bullido, M; Panza, F; Caffarra, P; Nacmias, B; Gilbert, J R; Mayhaus, M; Lannefelt, L; Hakonarson, H; Pichler, S; Carrasquillo, M M; Ingelsson, M; Beekly, D; Alvarez, V; Zou, F; Valladares, O; Younkin, S G; Coto, E; Hamilton-Nelson, K L; Gu, W; Razquin, C; Pastor, P; Mateo, I; Owen, M J; Faber, K M; Jonsson, P V; Combarros, O; O'Donovan, M C; Cantwell, L B; Soininen, H; Blacker, D; Mead, S; Mosley, T H; Bennett, D A; Harris, T B; Fratiglioni, L; Holmes, C; de Bruijn, R F; Passmore, P; Montine, T J; Bettens, K; Rotter, J I; Brice, A; Morgan, K; Foroud, T M; Kukull, W A; Hannequin, D; Powell, J F; Nalls, M A; Ritchie, K; Lunetta, K L; Kauwe, J S; Boerwinkle, E; Riemenschneider, M; Boada, M; Hiltuenen, M; Martin, E R; Schmidt, R; Rujescu, D; Wang, L S; Dartigues, J F; Mayeux, R; Tzourio, C; Hofman, A; Nöthen, M M; Graff, C; Psaty, B M; Jones, L; Haines, J L; Holmans, P A; Lathrop, M; Pericak-Vance, M A; Launer, L J; Farrer, L A; van Duijn, C M; Van Broeckhoven, C; Moskvina, V; Seshadri, S; Williams, J; Schellenberg, G D; Amouyel, P; European Alzheimer's Disease Initiative (EADI).

in: NAT GENET, Jahrgang 45, Nr. 12, 01.12.2013, S. 1452-8.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Lambert, JC, Ibrahim-Verbaas, CA, Harold, D, Naj, AC, Sims, R, Bellenguez, C, DeStafano, AL, Bis, JC, Beecham, GW, Grenier-Boley, B, Russo, G, Thorton-Wells, TA, Jones, N, Smith, AV, Chouraki, V, Thomas, C, Ikram, MA, Zelenika, D, Vardarajan, BN, Kamatani, Y, Lin, CF, Gerrish, A, Schmidt, H, Kunkle, B, Dunstan, ML, Ruiz, A, Bihoreau, MT, Choi, SH, Reitz, C, Pasquier, F, Cruchaga, C, Craig, D, Amin, N, Berr, C, Lopez, OL, De Jager, PL, Deramecourt, V, Johnston, JA, Evans, D, Lovestone, S, Letenneur, L, Morón, FJ, Rubinsztein, DC, Eiriksdottir, G, Sleegers, K, Goate, AM, Fiévet, N, Huentelman, MW, Gill, M, Brown, K, Kamboh, MI, Keller, L, Barberger-Gateau, P, McGuiness, B, Larson, EB, Green, R, Myers, AJ, Dufouil, C, Todd, S, Wallon, D, Love, S, Rogaeva, E, Gallacher, J, St George-Hyslop, P, Clarimon, J, Lleo, A, Bayer, A, Tsuang, DW, Yu, L, Tsolaki, M, Bossù, P, Spalletta, G, Proitsi, P, Collinge, J, Sorbi, S, Sanchez-Garcia, F, Fox, NC, Hardy, J, Deniz Naranjo, MC, Bosco, P, Clarke, R, Brayne, C, Galimberti, D, Mancuso, M, Matthews, F, Moebus, S, Mecocci, P, Del Zompo, M, Maier, W, Hampel, H, Pilotto, A, Bullido, M, Panza, F, Caffarra, P, Nacmias, B, Gilbert, JR, Mayhaus, M, Lannefelt, L, Hakonarson, H, Pichler, S, Carrasquillo, MM, Ingelsson, M, Beekly, D, Alvarez, V, Zou, F, Valladares, O, Younkin, SG, Coto, E, Hamilton-Nelson, KL, Gu, W, Razquin, C, Pastor, P, Mateo, I, Owen, MJ, Faber, KM, Jonsson, PV, Combarros, O, O'Donovan, MC, Cantwell, LB, Soininen, H, Blacker, D, Mead, S, Mosley, TH, Bennett, DA, Harris, TB, Fratiglioni, L, Holmes, C, de Bruijn, RF, Passmore, P, Montine, TJ, Bettens, K, Rotter, JI, Brice, A, Morgan, K, Foroud, TM, Kukull, WA, Hannequin, D, Powell, JF, Nalls, MA, Ritchie, K, Lunetta, KL, Kauwe, JS, Boerwinkle, E, Riemenschneider, M, Boada, M, Hiltuenen, M, Martin, ER, Schmidt, R, Rujescu, D, Wang, LS, Dartigues, JF, Mayeux, R, Tzourio, C, Hofman, A, Nöthen, MM, Graff, C, Psaty, BM, Jones, L, Haines, JL, Holmans, PA, Lathrop, M, Pericak-Vance, MA, Launer, LJ, Farrer, LA, van Duijn, CM, Van Broeckhoven, C, Moskvina, V, Seshadri, S, Williams, J, Schellenberg, GD, Amouyel, P & European Alzheimer's Disease Initiative (EADI) 2013, 'Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease', NAT GENET, Jg. 45, Nr. 12, S. 1452-8. https://doi.org/10.1038/ng.2802

APA

Lambert, J. C., Ibrahim-Verbaas, C. A., Harold, D., Naj, A. C., Sims, R., Bellenguez, C., DeStafano, A. L., Bis, J. C., Beecham, G. W., Grenier-Boley, B., Russo, G., Thorton-Wells, T. A., Jones, N., Smith, A. V., Chouraki, V., Thomas, C., Ikram, M. A., Zelenika, D., Vardarajan, B. N., ... European Alzheimer's Disease Initiative (EADI) (2013). Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. NAT GENET, 45(12), 1452-8. https://doi.org/10.1038/ng.2802

Vancouver

Lambert JC, Ibrahim-Verbaas CA, Harold D, Naj AC, Sims R, Bellenguez C et al. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. NAT GENET. 2013 Dez 1;45(12):1452-8. https://doi.org/10.1038/ng.2802

Bibtex

@article{316a3e145a434818bec72d48009693fe,

title = "Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease",

abstract = "Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous studies; however, a large portion of the genetic risk for this disease remains unexplained. We conducted a large, two-stage meta-analysis of genome-wide association studies (GWAS) in individuals of European ancestry. In stage 1, we used genotyped and imputed data (7,055,881 SNPs) to perform meta-analysis on 4 previously published GWAS data sets consisting of 17,008 Alzheimer's disease cases and 37,154 controls. In stage 2, 11,632 SNPs were genotyped and tested for association in an independent set of 8,572 Alzheimer's disease cases and 11,312 controls. In addition to the APOE locus (encoding apolipoprotein E), 19 loci reached genome-wide significance (P < 5 × 10(-8)) in the combined stage 1 and stage 2 analysis, of which 11 are newly associated with Alzheimer's disease.",

keywords = "Age of Onset, Aged, Aged, 80 and over, Alzheimer Disease, Case-Control Studies, Cohort Studies, Female, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide",

author = "Lambert, {J C} and Ibrahim-Verbaas, {C A} and D Harold and Naj, {A C} and R Sims and C Bellenguez and DeStafano, {A L} and Bis, {J C} and Beecham, {G W} and B Grenier-Boley and G Russo and Thorton-Wells, {T A} and N Jones and Smith, {A V} and V Chouraki and C Thomas and Ikram, {M A} and D Zelenika and Vardarajan, {B N} and Y Kamatani and Lin, {C F} and A Gerrish and H Schmidt and B Kunkle and Dunstan, {M L} and A Ruiz and Bihoreau, {M T} and Choi, {S H} and C Reitz and F Pasquier and C Cruchaga and D Craig and N Amin and C Berr and Lopez, {O L} and {De Jager}, {P L} and V Deramecourt and Johnston, {J A} and D Evans and S Lovestone and L Letenneur and Mor{\'o}n, {F J} and Rubinsztein, {D C} and G Eiriksdottir and K Sleegers and Goate, {A M} and N Fi{\'e}vet and Huentelman, {M W} and M Gill and K Brown and Kamboh, {M I} and L Keller and P Barberger-Gateau and B McGuiness and Larson, {E B} and R Green and Myers, {A J} and C Dufouil and S Todd and D Wallon and S Love and E Rogaeva and J Gallacher and {St George-Hyslop}, P and J Clarimon and A Lleo and A Bayer and Tsuang, {D W} and L Yu and M Tsolaki and P Boss{\`u} and G Spalletta and P Proitsi and J Collinge and S Sorbi and F Sanchez-Garcia and Fox, {N C} and J Hardy and {Deniz Naranjo}, {M C} and P Bosco and R Clarke and C Brayne and D Galimberti and M Mancuso and F Matthews and S Moebus and P Mecocci and {Del Zompo}, M and W Maier and H Hampel and A Pilotto and M Bullido and F Panza and P Caffarra and B Nacmias and Gilbert, {J R} and M Mayhaus and L Lannefelt and H Hakonarson and S Pichler and Carrasquillo, {M M} and M Ingelsson and D Beekly and V Alvarez and F Zou and O Valladares and Younkin, {S G} and E Coto and Hamilton-Nelson, {K L} and W Gu and C Razquin and P Pastor and I Mateo and Owen, {M J} and Faber, {K M} and Jonsson, {P V} and O Combarros and O'Donovan, {M C} and Cantwell, {L B} and H Soininen and D Blacker and S Mead and Mosley, {T H} and Bennett, {D A} and Harris, {T B} and L Fratiglioni and C Holmes and {de Bruijn}, {R F} and P Passmore and Montine, {T J} and K Bettens and Rotter, {J I} and A Brice and K Morgan and Foroud, {T M} and Kukull, {W A} and D Hannequin and Powell, {J F} and Nalls, {M A} and K Ritchie and Lunetta, {K L} and Kauwe, {J S} and E Boerwinkle and M Riemenschneider and M Boada and M Hiltuenen and Martin, {E R} and R Schmidt and D Rujescu and Wang, {L S} and Dartigues, {J F} and R Mayeux and C Tzourio and A Hofman and N{\"o}then, {M M} and C Graff and Psaty, {B M} and L Jones and Haines, {J L} and Holmans, {P A} and M Lathrop and Pericak-Vance, {M A} and Launer, {L J} and Farrer, {L A} and {van Duijn}, {C M} and {Van Broeckhoven}, C and V Moskvina and S Seshadri and J Williams and Schellenberg, {G D} and P Amouyel and {European Alzheimer's Disease Initiative (EADI)} and {van den Bussche}, Hendrik",

year = "2013",

month = dec,

day = "1",

doi = "10.1038/ng.2802",

language = "English",

volume = "45",

pages = "1452--8",

journal = "NAT GENET",

issn = "1061-4036",

publisher = "NATURE PUBLISHING GROUP",

number = "12",

}

RIS

TY - JOUR

T1 - Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

AU - Lambert, J C

AU - Ibrahim-Verbaas, C A

AU - Harold, D

AU - Naj, A C

AU - Sims, R

AU - Bellenguez, C

AU - DeStafano, A L

AU - Bis, J C

AU - Beecham, G W

AU - Grenier-Boley, B

AU - Russo, G

AU - Thorton-Wells, T A

AU - Jones, N

AU - Smith, A V

AU - Chouraki, V

AU - Thomas, C

AU - Ikram, M A

AU - Zelenika, D

AU - Vardarajan, B N

AU - Kamatani, Y

AU - Lin, C F

AU - Gerrish, A

AU - Schmidt, H

AU - Kunkle, B

AU - Dunstan, M L

AU - Ruiz, A

AU - Bihoreau, M T

AU - Choi, S H

AU - Reitz, C

AU - Pasquier, F

AU - Cruchaga, C

AU - Craig, D

AU - Amin, N

AU - Berr, C

AU - Lopez, O L

AU - De Jager, P L

AU - Deramecourt, V

AU - Johnston, J A

AU - Evans, D

AU - Lovestone, S

AU - Letenneur, L

AU - Morón, F J

AU - Rubinsztein, D C

AU - Eiriksdottir, G

AU - Sleegers, K

AU - Goate, A M

AU - Fiévet, N

AU - Huentelman, M W

AU - Gill, M

AU - Brown, K

AU - Kamboh, M I

AU - Keller, L

AU - Barberger-Gateau, P

AU - McGuiness, B

AU - Larson, E B

AU - Green, R

AU - Myers, A J

AU - Dufouil, C

AU - Todd, S

AU - Wallon, D

AU - Love, S

AU - Rogaeva, E

AU - Gallacher, J

AU - St George-Hyslop, P

AU - Clarimon, J

AU - Lleo, A

AU - Bayer, A

AU - Tsuang, D W

AU - Yu, L

AU - Tsolaki, M

AU - Bossù, P

AU - Spalletta, G

AU - Proitsi, P

AU - Collinge, J

AU - Sorbi, S

AU - Sanchez-Garcia, F

AU - Fox, N C

AU - Hardy, J

AU - Deniz Naranjo, M C

AU - Bosco, P

AU - Clarke, R

AU - Brayne, C

AU - Galimberti, D

AU - Mancuso, M

AU - Matthews, F

AU - Moebus, S

AU - Mecocci, P

AU - Del Zompo, M

AU - Maier, W

AU - Hampel, H

AU - Pilotto, A

AU - Bullido, M

AU - Panza, F

AU - Caffarra, P

AU - Nacmias, B

AU - Gilbert, J R

AU - Mayhaus, M

AU - Lannefelt, L

AU - Hakonarson, H

AU - Pichler, S

AU - Carrasquillo, M M

AU - Ingelsson, M

AU - Beekly, D

AU - Alvarez, V

AU - Zou, F

AU - Valladares, O

AU - Younkin, S G

AU - Coto, E

AU - Hamilton-Nelson, K L

AU - Gu, W

AU - Razquin, C

AU - Pastor, P

AU - Mateo, I

AU - Owen, M J

AU - Faber, K M

AU - Jonsson, P V

AU - Combarros, O

AU - O'Donovan, M C

AU - Cantwell, L B

AU - Soininen, H

AU - Blacker, D

AU - Mead, S

AU - Mosley, T H

AU - Bennett, D A

AU - Harris, T B

AU - Fratiglioni, L

AU - Holmes, C

AU - de Bruijn, R F

AU - Passmore, P

AU - Montine, T J

AU - Bettens, K

AU - Rotter, J I

AU - Brice, A

AU - Morgan, K

AU - Foroud, T M

AU - Kukull, W A

AU - Hannequin, D

AU - Powell, J F

AU - Nalls, M A

AU - Ritchie, K

AU - Lunetta, K L

AU - Kauwe, J S

AU - Boerwinkle, E

AU - Riemenschneider, M

AU - Boada, M

AU - Hiltuenen, M

AU - Martin, E R

AU - Schmidt, R

AU - Rujescu, D

AU - Wang, L S

AU - Dartigues, J F

AU - Mayeux, R

AU - Tzourio, C

AU - Hofman, A

AU - Nöthen, M M

AU - Graff, C

AU - Psaty, B M

AU - Jones, L

AU - Haines, J L

AU - Holmans, P A

AU - Lathrop, M

AU - Pericak-Vance, M A

AU - Launer, L J

AU - Farrer, L A

AU - van Duijn, C M

AU - Van Broeckhoven, C

AU - Moskvina, V

AU - Seshadri, S

AU - Williams, J

AU - Schellenberg, G D

AU - Amouyel, P

AU - European Alzheimer's Disease Initiative (EADI)

AU - van den Bussche, Hendrik

PY - 2013/12/1

Y1 - 2013/12/1

N2 - Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous studies; however, a large portion of the genetic risk for this disease remains unexplained. We conducted a large, two-stage meta-analysis of genome-wide association studies (GWAS) in individuals of European ancestry. In stage 1, we used genotyped and imputed data (7,055,881 SNPs) to perform meta-analysis on 4 previously published GWAS data sets consisting of 17,008 Alzheimer's disease cases and 37,154 controls. In stage 2, 11,632 SNPs were genotyped and tested for association in an independent set of 8,572 Alzheimer's disease cases and 11,312 controls. In addition to the APOE locus (encoding apolipoprotein E), 19 loci reached genome-wide significance (P < 5 × 10(-8)) in the combined stage 1 and stage 2 analysis, of which 11 are newly associated with Alzheimer's disease.

AB - Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous studies; however, a large portion of the genetic risk for this disease remains unexplained. We conducted a large, two-stage meta-analysis of genome-wide association studies (GWAS) in individuals of European ancestry. In stage 1, we used genotyped and imputed data (7,055,881 SNPs) to perform meta-analysis on 4 previously published GWAS data sets consisting of 17,008 Alzheimer's disease cases and 37,154 controls. In stage 2, 11,632 SNPs were genotyped and tested for association in an independent set of 8,572 Alzheimer's disease cases and 11,312 controls. In addition to the APOE locus (encoding apolipoprotein E), 19 loci reached genome-wide significance (P < 5 × 10(-8)) in the combined stage 1 and stage 2 analysis, of which 11 are newly associated with Alzheimer's disease.

KW - Age of Onset

KW - Aged

KW - Aged, 80 and over

KW - Alzheimer Disease

KW - Case-Control Studies

KW - Cohort Studies

KW - Female

KW - Genetic Loci

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - Humans

KW - Male

KW - Middle Aged

KW - Polymorphism, Single Nucleotide

U2 - 10.1038/ng.2802

DO - 10.1038/ng.2802

M3 - SCORING: Journal article

C2 - 24162737

VL - 45

SP - 1452

EP - 1458

JO - NAT GENET

JF - NAT GENET

SN - 1061-4036

IS - 12

ER -