Meroterpenoids from the alga-derived fungi Penicillium thomii Maire and Penicillium lividum Westling
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Meroterpenoids from the alga-derived fungi Penicillium thomii Maire and Penicillium lividum Westling. / Zhuravleva, Olesya I; Sobolevskaya, Maria P; Leshchenko, Elena V; Kirichuk, Natalya N; Denisenko, Vladimir A; Dmitrenok, Pavel S; Dyshlovoy, Sergey A; Zakharenko, Alexander M; Kim, Natalya Yu; Afiyatullov, Shamil Sh.
in: J NAT PROD, Jahrgang 77, Nr. 6, 27.06.2014, S. 1390-5.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Meroterpenoids from the alga-derived fungi Penicillium thomii Maire and Penicillium lividum Westling
AU - Zhuravleva, Olesya I
AU - Sobolevskaya, Maria P
AU - Leshchenko, Elena V
AU - Kirichuk, Natalya N
AU - Denisenko, Vladimir A
AU - Dmitrenok, Pavel S
AU - Dyshlovoy, Sergey A
AU - Zakharenko, Alexander M
AU - Kim, Natalya Yu
AU - Afiyatullov, Shamil Sh
PY - 2014/6/27
Y1 - 2014/6/27
N2 - Ten new austalide meroterpenoids (1-10) were isolated from the alga-derived fungi Penicillium thomii KMM 4645 and Penicillium lividum KMM 4663. Their structures were elucidated by extensive spectroscopic analysis and by comparison with related known compounds. The absolute configurations of some of the metabolites were assigned by the modified Mosher's method and CD data. Compounds 1, 2, 8, and 9 were able to inhibit AP-1-dependent transcriptional activity in JB6 Cl41 cell lines at noncytotoxic concentrations. Austalides 1-5, 8, and 9 exhibited significant inhibitory activity against endo-1,3-β-D-glucanase from a crystalline stalk of the marine mollusk Pseudocardium sachalinensis.
AB - Ten new austalide meroterpenoids (1-10) were isolated from the alga-derived fungi Penicillium thomii KMM 4645 and Penicillium lividum KMM 4663. Their structures were elucidated by extensive spectroscopic analysis and by comparison with related known compounds. The absolute configurations of some of the metabolites were assigned by the modified Mosher's method and CD data. Compounds 1, 2, 8, and 9 were able to inhibit AP-1-dependent transcriptional activity in JB6 Cl41 cell lines at noncytotoxic concentrations. Austalides 1-5, 8, and 9 exhibited significant inhibitory activity against endo-1,3-β-D-glucanase from a crystalline stalk of the marine mollusk Pseudocardium sachalinensis.
KW - Animals
KW - Aspergillus
KW - Drug Screening Assays, Antitumor
KW - Japan
KW - Mice
KW - Molecular Structure
KW - Nuclear Magnetic Resonance, Biomolecular
KW - Oceans and Seas
KW - Penicillium
KW - Sargassum
KW - Terpenes
KW - Transcription Factor AP-1
U2 - 10.1021/np500151b
DO - 10.1021/np500151b
M3 - SCORING: Journal article
C2 - 24852445
VL - 77
SP - 1390
EP - 1395
JO - J NAT PROD
JF - J NAT PROD
SN - 0163-3864
IS - 6
ER -