Mental disorders and the risk for the subsequent first suicide attempt: results of a community study on adolescents and young adults

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Mental disorders and the risk for the subsequent first suicide attempt: results of a community study on adolescents and young adults. / Miché, Marcel; Hofer, Patrizia Denise; Voss, Catharina; Meyer, Andrea Hans; Gloster, Andrew Thomas; Beesdo-Baum, Katja; Lieb, Roselind.

in: EUR CHILD ADOLES PSY, Jahrgang 27, Nr. 7, 07.2018, S. 839-848.

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@article{2b176cd905c74a19b2582079913715ae,
title = "Mental disorders and the risk for the subsequent first suicide attempt: results of a community study on adolescents and young adults",
abstract = "Adolescents and young adults represent the high-risk group for first onset of both DSM-IV mental disorders and lifetime suicide attempt (SA). Yet few studies have evaluated the temporal association of prior mental disorders and subsequent first SA in a young community sample. We examined (a) such associations using a broad range of specific DSM-IV mental disorders, (b) the risk of experiencing the outcome due to prior comorbidity, and (c) the proportion of SAs that could be attributed to prior disorders. During a 10-year prospective study, data were gathered from 3021 community subjects, 14-24 years of age at baseline. DSM-IV disorders and SA were assessed with the Munich-Composite International Diagnostic Interview. Cox models with time-dependent covariates were used to estimate the temporal associations of prior mental disorders with subsequent first SA. Most prior mental disorders showed elevated risk for subsequent first SA. Highest risks were associated with posttraumatic stress disorder (PTSD), dysthymia, and nicotine dependence. Comorbidity elevated the risk for subsequent first SA, and the more disorders a subject had, the higher the risk for first SA. More than 90% of SAs in the exposed group could be attributed to PTSD, and over 30% of SAs in the total sample could be attributed to specific phobia. Several DSM-IV disorders increase the risk for first SA in adolescents and young adults. Several promising early intervention targets were observed, e.g., specific phobia, nicotine dependence, dysthymia, and whether a young person is burdened with comorbid mental disorders.",
keywords = "Adolescent, Adult, Female, Humans, Longitudinal Studies, Male, Mental Disorders/epidemiology, Prospective Studies, Risk Factors, Suicide, Attempted/psychology, Surveys and Questionnaires, Young Adult",
author = "Marcel Mich{\'e} and Hofer, {Patrizia Denise} and Catharina Voss and Meyer, {Andrea Hans} and Gloster, {Andrew Thomas} and Katja Beesdo-Baum and Roselind Lieb",
year = "2018",
month = jul,
doi = "10.1007/s00787-017-1060-5",
language = "English",
volume = "27",
pages = "839--848",
journal = "EUR CHILD ADOLES PSY",
issn = "1018-8827",
publisher = "D. Steinkopff-Verlag",
number = "7",

}

RIS

TY - JOUR

T1 - Mental disorders and the risk for the subsequent first suicide attempt: results of a community study on adolescents and young adults

AU - Miché, Marcel

AU - Hofer, Patrizia Denise

AU - Voss, Catharina

AU - Meyer, Andrea Hans

AU - Gloster, Andrew Thomas

AU - Beesdo-Baum, Katja

AU - Lieb, Roselind

PY - 2018/7

Y1 - 2018/7

N2 - Adolescents and young adults represent the high-risk group for first onset of both DSM-IV mental disorders and lifetime suicide attempt (SA). Yet few studies have evaluated the temporal association of prior mental disorders and subsequent first SA in a young community sample. We examined (a) such associations using a broad range of specific DSM-IV mental disorders, (b) the risk of experiencing the outcome due to prior comorbidity, and (c) the proportion of SAs that could be attributed to prior disorders. During a 10-year prospective study, data were gathered from 3021 community subjects, 14-24 years of age at baseline. DSM-IV disorders and SA were assessed with the Munich-Composite International Diagnostic Interview. Cox models with time-dependent covariates were used to estimate the temporal associations of prior mental disorders with subsequent first SA. Most prior mental disorders showed elevated risk for subsequent first SA. Highest risks were associated with posttraumatic stress disorder (PTSD), dysthymia, and nicotine dependence. Comorbidity elevated the risk for subsequent first SA, and the more disorders a subject had, the higher the risk for first SA. More than 90% of SAs in the exposed group could be attributed to PTSD, and over 30% of SAs in the total sample could be attributed to specific phobia. Several DSM-IV disorders increase the risk for first SA in adolescents and young adults. Several promising early intervention targets were observed, e.g., specific phobia, nicotine dependence, dysthymia, and whether a young person is burdened with comorbid mental disorders.

AB - Adolescents and young adults represent the high-risk group for first onset of both DSM-IV mental disorders and lifetime suicide attempt (SA). Yet few studies have evaluated the temporal association of prior mental disorders and subsequent first SA in a young community sample. We examined (a) such associations using a broad range of specific DSM-IV mental disorders, (b) the risk of experiencing the outcome due to prior comorbidity, and (c) the proportion of SAs that could be attributed to prior disorders. During a 10-year prospective study, data were gathered from 3021 community subjects, 14-24 years of age at baseline. DSM-IV disorders and SA were assessed with the Munich-Composite International Diagnostic Interview. Cox models with time-dependent covariates were used to estimate the temporal associations of prior mental disorders with subsequent first SA. Most prior mental disorders showed elevated risk for subsequent first SA. Highest risks were associated with posttraumatic stress disorder (PTSD), dysthymia, and nicotine dependence. Comorbidity elevated the risk for subsequent first SA, and the more disorders a subject had, the higher the risk for first SA. More than 90% of SAs in the exposed group could be attributed to PTSD, and over 30% of SAs in the total sample could be attributed to specific phobia. Several DSM-IV disorders increase the risk for first SA in adolescents and young adults. Several promising early intervention targets were observed, e.g., specific phobia, nicotine dependence, dysthymia, and whether a young person is burdened with comorbid mental disorders.

KW - Adolescent

KW - Adult

KW - Female

KW - Humans

KW - Longitudinal Studies

KW - Male

KW - Mental Disorders/epidemiology

KW - Prospective Studies

KW - Risk Factors

KW - Suicide, Attempted/psychology

KW - Surveys and Questionnaires

KW - Young Adult

U2 - 10.1007/s00787-017-1060-5

DO - 10.1007/s00787-017-1060-5

M3 - SCORING: Journal article

C2 - 29027588

VL - 27

SP - 839

EP - 848

JO - EUR CHILD ADOLES PSY

JF - EUR CHILD ADOLES PSY

SN - 1018-8827

IS - 7

ER -