Mendelian randomisation study of smoking exposure in relation to breast cancer risk
Beteiligte Einrichtungen
Abstract
studies, it is still equivocal whether smoking is causally related to breast cancer risk.
METHODS: We applied Mendelian randomisation (MR) to evaluate a potential causal effect of cigarette smoking on breast cancer
risk. Both individual-level data as well as summary statistics for 164 single-nucleotide polymorphisms (SNPs) reported in genomewide
association studies of lifetime smoking index (LSI) or cigarette per day (CPD) were used to obtain MR effect estimates. Data
from 108,420 invasive breast cancer cases and 87,681 controls were used for the LSI analysis and for the CPD analysis conducted
among ever-smokers from 26,147 cancer cases and 26,072 controls. Sensitivity analyses were conducted to address pleiotropy.
RESULTS: Genetically predicted LSI was associated with increased breast cancer risk (OR 1.18 per SD, 95% CI: 1.07–1.30, P = 0.11 ×
10–2), but there was no evidence of association for genetically predicted CPD (OR 1.02, 95% CI: 0.78–1.19, P = 0.85). The sensitivity
analyses yielded similar results and showed no strong evidence of pleiotropic effect.
CONCLUSION: Our MR study provides supportive evidence for a potential causal association with breast cancer risk for lifetime
smoking exposure but not cigarettes per day among smokers.
Bibliografische Daten
Originalsprache | Englisch |
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ISSN | 0007-0920 |
DOIs | |
Status | Veröffentlicht - 10.2021 |
PubMed | 34341517 |
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