Megalospermatocytes in the human testis exhibit asynapsis of chromosomes.
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Megalospermatocytes in the human testis exhibit asynapsis of chromosomes. / Johannisson, R; Schulze, Wolfgang; Holstein, A F.
in: ANDROLOGIA, Jahrgang 35, Nr. 3, 3, 2003, S. 146-151.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Megalospermatocytes in the human testis exhibit asynapsis of chromosomes.
AU - Johannisson, R
AU - Schulze, Wolfgang
AU - Holstein, A F
PY - 2003
Y1 - 2003
N2 - Testis biopsies of three infertile patients were identified, which showed a predomination of megalospermatocytes in the seminiferous tubules. Megalospermatocytes are very large primary spermatocytes indicating a spermatogenic arrest. Because of the high percentage of these germ cells it was possible to apply a whole-mount spreading technique to investigate the chromosomal pairing behaviour in prophase I of meiosis. It could be shown that most of the megalospermatocytes exhibited extensive chromosomal asynapsis, suggesting that a characteristic meiotic disorder may give rise to reduced fertility, or even infertility.
AB - Testis biopsies of three infertile patients were identified, which showed a predomination of megalospermatocytes in the seminiferous tubules. Megalospermatocytes are very large primary spermatocytes indicating a spermatogenic arrest. Because of the high percentage of these germ cells it was possible to apply a whole-mount spreading technique to investigate the chromosomal pairing behaviour in prophase I of meiosis. It could be shown that most of the megalospermatocytes exhibited extensive chromosomal asynapsis, suggesting that a characteristic meiotic disorder may give rise to reduced fertility, or even infertility.
M3 - SCORING: Zeitschriftenaufsatz
VL - 35
SP - 146
EP - 151
JO - ANDROLOGIA
JF - ANDROLOGIA
SN - 0303-4569
IS - 3
M1 - 3
ER -
