Medication Adherence in a Cross-Diagnostic Sample of Patients From the Affective-to-Psychotic Spectrum: Results From the PsyCourse Study

TY - JOUR

T1 - Medication Adherence in a Cross-Diagnostic Sample of Patients From the Affective-to-Psychotic Spectrum: Results From the PsyCourse Study

AU - Kirchner, Sophie-Kathrin

AU - Lauseker, Michael

AU - Adorjan, Kristina

AU - Anderson-Schmidt, Heike

AU - Anghelescu, Ion-George

AU - Baune, Bernhardt T

AU - Budde, Monika

AU - Dannlowski, Udo

AU - Dietrich, Detlef E

AU - Fallgatter, Andreas J

AU - Falkai, Peter

AU - Figge, Christian

AU - Gade, Katrin

AU - Heilbronner, Urs

AU - Hiendl, Lena

AU - Juckel, Georg

AU - Kalman, Janos L

AU - Klöhn-Saghatolislam, Farahnaz

AU - Konrad, Carsten

AU - Lang, Fabian U

AU - Oraki Kohshour, Mojtaba

AU - Papiol, Sergi

AU - Reich-Erkelenz, Daniela

AU - Reimer, Jens

AU - Reininghaus, Eva Z

AU - Schaupp, Sabrina K

AU - Schmauß, Max

AU - Schmitt, Andrea

AU - Schulte, Eva Christina

AU - Senner, Simon

AU - Spitzer, Carsten

AU - Vogl, Thomas

AU - Zimmermann, Jörg

AU - Hasan, Alkomiet

AU - Schulze, Thomas G

AU - Senner, Fanny

N1 - Copyright © 2022 Kirchner, Lauseker, Adorjan, Anderson-Schmidt, Anghelescu, Baune, Budde, Dannlowski, Dietrich, Fallgatter, Falkai, Figge, Gade, Heilbronner, Hiendl, Juckel, Kalman, Klöhn-Saghatolislam, Konrad, Lang, Oraki Kohshour, Papiol, Reich-Erkelenz, Reimer, Reininghaus, Schaupp, Schmauß, Schmitt, Schulte, Senner, Spitzer, Vogl, Zimmermann, Hasan, Schulze and Senner.

PY - 2022/1/20

Y1 - 2022/1/20

N2 - INTRODUCTION: According to the World Health Organization, medication adherence is defined as the extent to which a person's behavior corresponds with an agreed recommendation from a healthcare provider. Approximately 50% of patients do not take their medication as prescribed, and non-adherence can contribute to the progress of a disease. For patients suffering from mental diseases non-adherence plays an important role. Various factors have been proposed as contributing to non-adherence, however the literature remains heterogeneous dependent on the analyzed patient subgroups. This study comprehensively evaluates the association of sociodemographic, clinical, personality and quality of life related factors with medication adherence by analyzing data from the PsyCourse study. The PsyCourse study is a large and cross-diagnostic cohort of psychiatric patients from the affective-to-psychotic spectrum.METHODS: The study sample comprised 1,062 patients from the PsyCourse study with various psychiatric diagnoses (mean [SD] age, 42.82 [12.98] years; 47.4% female). Data were analyzed to identify specific factors associated with medication adherence, and adherence was measured by a self-rating questionnaire. Odds ratios (OR) were estimated by a logistic regression for binary outcomes. Missing data were imputed using multiple imputation.RESULTS: The following factors showed the strongest association with medication adherence: never having used illicit drugs (OR, 0.71), number of prescribed antipsychotics (OR, 1.40), the personality trait conscientiousness (OR, 1.26), and the environmental domain of quality of life (OR, 1.09).CONCLUSION: In a large and cross-diagnostic sample, we could show that a higher level of conscientiousness, a higher number of antipsychotic medication, a better quality of life within the environmental domain, and the absence of substance abuse contribute to a better medication adherence independent of the underlying disorder.

AB - INTRODUCTION: According to the World Health Organization, medication adherence is defined as the extent to which a person's behavior corresponds with an agreed recommendation from a healthcare provider. Approximately 50% of patients do not take their medication as prescribed, and non-adherence can contribute to the progress of a disease. For patients suffering from mental diseases non-adherence plays an important role. Various factors have been proposed as contributing to non-adherence, however the literature remains heterogeneous dependent on the analyzed patient subgroups. This study comprehensively evaluates the association of sociodemographic, clinical, personality and quality of life related factors with medication adherence by analyzing data from the PsyCourse study. The PsyCourse study is a large and cross-diagnostic cohort of psychiatric patients from the affective-to-psychotic spectrum.METHODS: The study sample comprised 1,062 patients from the PsyCourse study with various psychiatric diagnoses (mean [SD] age, 42.82 [12.98] years; 47.4% female). Data were analyzed to identify specific factors associated with medication adherence, and adherence was measured by a self-rating questionnaire. Odds ratios (OR) were estimated by a logistic regression for binary outcomes. Missing data were imputed using multiple imputation.RESULTS: The following factors showed the strongest association with medication adherence: never having used illicit drugs (OR, 0.71), number of prescribed antipsychotics (OR, 1.40), the personality trait conscientiousness (OR, 1.26), and the environmental domain of quality of life (OR, 1.09).CONCLUSION: In a large and cross-diagnostic sample, we could show that a higher level of conscientiousness, a higher number of antipsychotic medication, a better quality of life within the environmental domain, and the absence of substance abuse contribute to a better medication adherence independent of the underlying disorder.

U2 - 10.3389/fpsyt.2021.713060

DO - 10.3389/fpsyt.2021.713060

M3 - SCORING: Journal article

C2 - 35126191

VL - 12

JO - FRONT PSYCHIATRY

JF - FRONT PSYCHIATRY

SN - 1664-0640

M1 - 713060

ER -